Developing a new resource for drug discovery: marine actinomycete bacteria

scientific article published in December 2006

Developing a new resource for drug discovery: marine actinomycete bacteria is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NCHEMBIO841
P698PubMed publication ID17108984
P5875ResearchGate publication ID6688822

P50authorWilliam H. FenicalQ27940392
P2093author name stringPaul R Jensen
P2860cites workpenimepicyclineQ4924638
Statistical approaches for estimating actinobacterial diversity in marine sedimentsQ24564940
Environmental genome shotgun sequencing of the Sargasso SeaQ27860605
The evolving role of natural products in drug discoveryQ28236671
Marine natural products and related compounds in clinical and advanced preclinical trialsQ28279168
Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.Q30764187
Salinibacterium amurskyense gen. nov., sp. nov., a novel genus of the family Microbacteriaceae from the marine environmentQ30885497
Serinicoccus marinus gen. nov., sp. nov., a novel actinomycete with L-ornithine and L-serine in the peptidoglycanQ30962269
Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomyceteQ30992750
Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family MicromonosporaceaeQ31004758
Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica".Q31033848
Biogeography of the marine actinomycete SalinisporaQ31063831
Bioactive microbial metabolitesQ31157729
Phenotypic taxonomy and metabolite profiling in microbial drug discoveryQ33227919
Diversity and biogeography of marine actinobacteriaQ33242319
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible bindingQ33994984
Biosynthesis of polyketides in heterologous hostsQ34010324
Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments.Q34095456
Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification modelQ34267723
The crisis in antibiotic resistanceQ34314442
A simple stereocontrolled synthesis of salinosporamide A.Q34321498
Total synthesis of salinosporamide A.Q34424488
New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropicaQ34437864
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from BortezomibQ34467271
Diversity of actinomycetes isolated from Challenger Deep sediment (10,898 m) from the Mariana Trench.Q34502267
Combinatorial biosynthesis of antibiotics: challenges and opportunitiesQ34580896
Natural products as sources of new drugs over the period 1981-2002.Q35184693
Distribution of actinomycetes in near-shore tropical marine sedimentsQ35689309
Lessons from natural moleculesQ35986033
Discovery of novel metabolites from marine actinomycetesQ36468507
Improved culturability of soil bacteria and isolation in pure culture of novel members of the divisions Acidobacteria, Actinobacteria, Proteobacteria, and Verrucomicrobia.Q39653368
Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora".Q40322949
Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitorQ40417479
Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolitesQ40623424
Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic predictionQ43234811
Vanadium haloperoxidase-catalyzed bromination and cyclization of terpenesQ44375538
Abyssomicin C-A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathwayQ44884023
Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp.Q45033612
Rhodococcus marinonascens sp. nov., an Actinomycete from the SeaQ45308813
Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis.Q49329153
Marine actinomycetes as a source of novel secondary metabolites.Q51537343
Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.Q53854609
Actinomycetes in North Sea and Atlantic Ocean SedimentsQ58972411
Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetaseQ60200787
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cellsQ67914016
The structure of roflamycoin, a new polyene macrolide antifungal antibioticQ70829407
Cyclomarins A−C, New Antiinflammatory Cyclic Peptides Produced by a Marine Bacterium (Streptomycessp.)Q78320302
Where will new antibiotics come from?Q79817299
A concise total synthesis of salinosporamide AQ79950454
Marinone and debromomarinone: Antibiotic sesquiterpenoid naphthoquinones of a new structure class from a marine bacteriumQ104986362
P433issue12
P921main subjectbacteriaQ10876
drug discoveryQ1418791
P304page(s)666-673
P577publication date2006-12-01
P1433published inNature Chemical BiologyQ904026
P1476titleDeveloping a new resource for drug discovery: marine actinomycete bacteria
P478volume2

Reverse relations

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Q37880884Rare actinomycetes: a potential storehouse for novel antibiotics
Q35657428Recent advances and applications of experimental technologies in marine natural product research.
Q36994135Recent advances in the discovery and development of marine microbial natural products.
Q96136096Role of symbiosis in the discovery of novel antibiotics
Q41772680Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.
Q33645464Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica
Q30586744Salinispora pacifica sp. nov., an actinomycete from marine sediments
Q34142223Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics
Q110169975Salternamide E from a Saltern-derived Marine ActinomyceteStreptomycessp.
Q61780889Screening Microorganisms for Bioactive Compounds
Q38768313Screening for Anti-Cancer Compounds in Marine Organisms in Oman
Q26860194Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage
Q46663876Seawater requirement for the production of lipoxazolidinones by marine actinomycete strain NPS8920.
Q110171483Secondary Metabolites from an Actinomycete from Vietnam's East Sea
Q102053820Selection of sponge-associated bacteria with high potential for the production of antibacterial compounds
Q37155588Separacenes A-D, novel polyene polyols from the marine actinomycete, Streptomyces sp.
Q33768204Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria
Q40429748Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.
Q41899611Sponge-derived Kocuria and Micrococcus spp. as sources of the new thiazolyl peptide antibiotic kocurin
Q45342316Stereoselective total syntheses of (-)-flueggine A and (+)-virosaine B.
Q38952662Stereoselective total synthesis and structural elucidation of (-)-indoxamycins A-F.
Q30908664Streptomyces alkaliphilus sp. nov., isolated from sediments of Lake Elmenteita in the Kenyan Rift Valley
Q45061228Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products
Q31016480Streptomyces hyaluromycini sp. nov., isolated from a tunicate (Molgula manhattensis).
Q116783913Streptomyces spiramenti sp. nov., isolated from a deep-sea microbial mat
Q27654081Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3
Q42230518Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit
Q35184486Structures and biosynthesis of the pyridinopyrones, polyenepyrones from a marine-derived Streptomyces species.
Q33908931Structures, reactivities, and antibiotic properties of the marinopyrroles A-F
Q34769635Studies on terpenoids produced by actinomycetes. 5-dimethylallylindole-3-carboxylic Acid and A80915G-8"-acid produced by marine-derived Streptomyces sp. MS239.
Q39394577Studies on the secondary metabolites of a Pseudoalteromonas sp. isolated from sediments collected at the northeastern coast of Brazil
Q105125506Synthesis, Structure and Antimicrobial Activity of Novel Metabolites from a Marine Actinomycete in Vietnam's East Sea
Q37424819Synthetic efforts for stereo structure determination of cytotoxic marine natural product pericosines as metabolites of Periconia sp. from sea hare
Q35541959Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform
Q34109331Terpenoids produced by actinomycetes: isolation, structural elucidation and biosynthesis of new diterpenes, gifhornenolones A and B from Verrucosispora gifhornensis YM28-088.
Q87823007Terretonin G, a new sesterterpenoid antibiotic from marine-derived Aspergillus sp. OPMF00272
Q36808494The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway
Q33644403The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species
Q35580082The antimicrobial activity of heterotrophic bacteria isolated from the marine sponge Erylus deficiens (Astrophorida, Geodiidae)
Q46334128The diversity and antibiotic properties of actinobacteria associated with endemic deepwater amphipods of Lake Baikal.
Q34465208The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery
Q33648791The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.
Q36851585The occurrence of bioactive micromonosporae in aquatic habitats of the Sunshine Coast in Australia
Q37831943The phenomenon of resveratrol: redefining the virtues of promiscuity
Q35305715The soil resistome: a critical review on antibiotic resistance origins, ecology and dissemination potential in telluric bacteria.
Q46187012The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440.
Q51705368Therapeutic treasures from the deep.
Q38920460Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora
Q39394537Total synthesis and stereochemical reassignment of (±)-indoxamycin B.
Q34100015Total synthesis of sporolide B and 9-epi-sporolide B.
Q37172692Total synthesis of sporolide B.
Q33687964Total synthesis of the ammosamides
Q42747319Total synthesis: A cascade of new antibiotics
Q42077605Two antimycin A analogues from marine-derived actinomycete Streptomyces lusitanus
Q57837771Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3
Q83262442Two new botcinin derivatives encountered in the studies of secondary metabolites from the marine-derived fungus Botryotinia sp. SF-5275
Q41569920Upregulation and Identification of Antibiotic Activity of a Marine-Derived Streptomyces sp. via Co-Cultures with Human Pathogens.
Q24684235What's new in enzymatic halogenations
Q57764036YOU MAKE IT, I BREAK IT
Q40998067α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells