Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease

scientific article published on 14 August 2013

Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPRENAL.00057.2013
P698PubMed publication ID23946291
P5875ResearchGate publication ID255955341

P2093author name stringLalita Uttarwar
Guang Chen
Bo Gao
Xing Chen
Alistair J Ingram
Joan C Krepinsky
Melissa Janssen
Tianxiu Guan
P2860cites workTherapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the ratQ28360398
Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and functionQ30443444
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.Q30481848
Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cellsQ30538069
Modelling the effects of vascular stress in mesangial cellsQ33828123
Impaired autoregulation of glomerular capillary hydrostatic pressure in the rat remnant nephronQ34225223
Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathwayQ35083367
Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the ratQ35608784
Smad3 as a mediator of the fibrotic responseQ35779047
Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly.Q36289136
A microtubule-dependent zone of active RhoA during cleavage plane specificationQ36320722
Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosisQ36362302
Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteinsQ36542089
Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameterQ37138832
Connective tissue growth factor: context-dependent functions and mechanisms of regulationQ37486405
Oral colchicine (Colcrys): in the treatment and prophylaxis of goutQ37778056
Colchicine: an old wine in a new bottle?Q38071323
Colchicine attenuates inflammatory cell infiltration and extracellular matrix accumulation in diabetic nephropathy.Q38495475
TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolaeQ41280741
RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulationQ42437398
Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulationQ42444937
Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstructionQ44225230
Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivoQ44265617
Mycophenolate mofetil prevents arteriolopathy and renal injury in subtotal ablation despite persistent hypertensionQ44358481
Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular toneQ44539503
Nitric Oxide Inhibits Stretch-Induced MAPK Activation in Mesangial Cells Through RhoA InactivationQ44625399
Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive ratsQ44665656
Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenaseQ44970228
Effect of colchicine on cyclosporine nephrotoxicity, reduction of TGF-beta overexpression, apoptosis, and oxidative damage: an experimental animal studyQ44976443
The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy.Q46013981
Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic ratsQ46691716
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice.Q52968773
P433issue10
P921main subject(S)-(−)-colchicineQ326224
P304page(s)F1466-76
P577publication date2013-08-14
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleColchicine attenuates renal injury in a model of hypertensive chronic kidney disease
P478volume305

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cites work (P2860)
Q98936115Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates
Q28082473Colchicine--Update on mechanisms of action and therapeutic uses
Q38905381Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys
Q36980406Inhibition of microtubule dynamics impedes repair of kidney ischemia/reperfusion injury and increases fibrosis
Q99633698Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein