HER2 gene amplification and chromosome 17 copy number do not predict survival of patients with resected pancreatic adenocarcinoma

scientific article published on 8 May 2008

HER2 gene amplification and chromosome 17 copy number do not predict survival of patients with resected pancreatic adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10620-008-0267-1
P698PubMed publication ID18463983

P2093author name stringKathleen Cieply
Ramesh K Ramanathan
Alyssa M Krasinskas
Saima Sharif
Douglas Potter
P2860cites workPrognostic and predictive value of HER2/neu oncogene in breast cancerQ34954864
Current management of locally advanced pancreatic cancerQ36304248
Role of immunohistochemical identification of Her-2/neu and detection of variability in overexpression in pancreatic carcinoma.Q38455600
HER2/neu expression and gene alterations in pancreatic ductal adenocarcinoma: a comparative immunohistochemistry and chromogenic in situ hybridization study based on tissue microarrays and computerized image analysisQ39754520
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesisQ40823460
Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neuQ45174616
c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependentQ45178475
Assessment of HER‐2/neu overexpression and/or gene amplification in breast carcinomas: should in situ hybridization be the method of choice?Q47906737
Amplification of a novel v-erbB-related gene in a human mammary carcinomaQ48375434
Assessment of HER-2 status in pancreatic adenocarcinoma: correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival.Q54649058
Overexpression of HER2/neu in solid tumours: an immunohistochemical surveyQ56441712
Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasmsQ71048246
HER-2/neu expression in pancreatic adenocarcinoma: relation to tumor differentiation and survivalQ73204437
Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomesQ73810358
HER2 testing in patients with breast cancer: poor correlation between weak positivity by immunohistochemistry and gene amplification by fluorescence in situ hybridizationQ77624096
HER-2-positive breast carcinomas as a particular subset with peculiar clinical behaviorsQ77626790
Expression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in human pancreatic ductal adenocarcinomaQ79273702
Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinomaQ81073375
Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumabQ81151636
Protein expression and gene amplification of epidermal growth factor receptor in thymomasQ81226237
Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patientsQ81414756
Comparison of immunohistochemical and fluorescence in situ hybridization assessment of HER-2 status in routine practiceQ81894783
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Untangling the ErbB signalling networkQ27860884
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancerQ28297827
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancerQ28678776
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Cancer statistics, 2006Q29615133
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancerQ29617440
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials GroupQ29619344
The HER-2/neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for TherapyQ33675112
HER2 as a prognostic factor in breast cancer.Q34428785
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancerQ34546440
Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patientsQ34722637
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapyQ34743875
Evidence-based pancreatic head resection for pancreatic cancer and chronic pancreatitisQ34778546
P433issue11
P921main subjectadenocarcinomaQ356033
P304page(s)3026-3032
P577publication date2008-05-08
P1433published inDigestive Diseases and SciencesQ15716711
P1476titleHER2 gene amplification and chromosome 17 copy number do not predict survival of patients with resected pancreatic adenocarcinoma
P478volume53

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cites work (P2860)
Q54734323HER-2/neu and topoisomerase-II-alpha expression and genic amplification in pancreatic adenocarcinoma.
Q36600002Prognostic role of HER2 amplification based on fluorescence in situ hybridization (FISH) in pancreatic ductal adenocarcinoma (PDAC): a meta-analysis
Q51075580Prognostıc value of increased HER2 expression in cancers of pancreas and biliary tree.
Q26859002The important molecular markers on chromosome 17 and their clinical impact in breast cancer

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