Comparative study of protective activities of Neospora caninum bradyzoite antigens, NcBAG1, NcBSR4, NcMAG1, and NcSAG4, in a mouse model of acute parasitic infection

scientific article published on 15 November 2012

Comparative study of protective activities of Neospora caninum bradyzoite antigens, NcBAG1, NcBSR4, NcMAG1, and NcSAG4, in a mouse model of acute parasitic infection is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1021253672
P356DOI10.1007/S00436-012-3182-5
P698PubMed publication ID23229317

P50authorAkira ItoQ88102777
Soichi ImaiQ108110728
P2093author name stringTakashi Murakami
Masaki Uchida
Kazunori Ike
Kotomi Nagashima
Yui Akatsuka
P2860cites workThe reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresisQ29053311
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Immunization of BALB/c mice with killed Neospora caninum tachyzoite antigen induces a type 2 immune response and exacerbates encephalitis and neurological diseaseQ33998711
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Neospora caninum in vitro: evidence that the destiny of a parasitophorous vacuole depends on the phenotype of the progenitor zoite.Q35029656
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In vitro induction of Neospora caninum bradyzoites in vero cells reveals differential antigen expression, localization, and host-cell recognition of tachyzoites and bradyzoitesQ36228120
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Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninumQ36497145
Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and NeosporaQ36726726
Cloning and characterization of a bradyzoite-specifically expressed gene (hsp30/bag1) of Toxoplasma gondii, related to genes encoding small heat-shock proteins of plants.Q36792835
Neospora caninum--how close are we to development of an efficacious vaccine that prevents abortion in cattle?Q37508256
Stress-driven stage transformation of Neospora caninum.Q37694345
Neospora caninum-associated abortion in cattle: the time of experimentally-induced parasitaemia during gestation determines foetal survivalQ39595158
Stage-specific expression of Nc SAG4 as a marker of chronic Neospora caninum infection in a mouse model.Q39858922
Immunogenicity of a killed whole Neospora caninum tachyzoite preparation formulated with different adjuvantsQ41710305
Molecular characterisation of BSR4, a novel bradyzoite-specific gene from Neospora caninum.Q42615285
The in vitro development of Neospora caninum bradyzoitesQ42725813
Usefulness of rNcGRA7- and rNcSAG4-based ELISA tests for distinguishing primo-infection, recrudescence, and chronic bovine neosporosis.Q43581667
Neospora caninum-like oocysts observed in feces of free-ranging red foxes (Vulpes vulpes) and coyotes (Canis latrans).Q43676390
Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoitesQ43704579
Immune responses in pregnant cattle and bovine fetuses following experimental infection with Neospora caninumQ43720700
Molecular characterization of Neospora caninum MAG1, a dense granule protein secreted into the parasitophorous vacuole, and associated with the cyst wall and the cyst matrixQ43734910
Induction of interferon-gamma (IFN-gamma) and T helper 1 (Th1) immune response by bitter gourd extractQ43876051
The differential protein expression profiles and immunogenicity of tachyzoites and bradyzoites of in vitro cultured Neospora caninumQ44165308
Optimization of the use of C57BL/6 mice as a laboratory animal model for Neospora caninum vaccine studiesQ44672993
Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model).Q45389107
Evaluation of an enzyme-linked immunosorbent assay for the detection of transmissible gastroenteritis virus antibodiesQ45835405
Identification of a gene cluster for cell-surface genes of the SRS superfamily in Neospora caninum and characterization of the novel SRS9 gene.Q45847227
Protective effects of immunization with a recombinant cyst antigen in mouse models of infection with Toxoplasma gondii tissue cystsQ46050882
Gene cloning and characterization of the protein encoded by the Neospora caninum bradyzoite-specific antigen gene BAG1.Q47830082
Identification and molecular cloning of the Neospora caninum SAG4 gene specifically expressed at bradyzoite stage.Q48111926
Immunization with native surface protein NcSRS2 induces a Th2 immune response and reduces congenital Neospora caninum transmission in miceQ48127809
Failure of a vaccine using immunogenic recombinant proteins rNcSAG4 and rNcGRA7 against neosporosis in mice.Q48448953
Comparison of intracerebral parasite load, lesion development, and systemic cytokines in mouse strains infected with Neospora caninum.Q48476343
Immune factors influencing the course of infection with Neospora caninum in the murine hostQ48585766
Neospora caninum: role for immune cytokines in host immunityQ48811296
Neospora caninum: quantification of DNA in the blood of naturally infected aborted and pregnant cows using real-time PCR.Q48946412
An immunohistochemical method for detecting bradyzoite antigen (BAG5) in Toxoplasma gondii-infected tissues cross-reacts with a Neospora caninum bradyzoite antigenQ49047817
Low efficacy of NcGRA7, NcSAG4, NcBSR4 and NcSRS9 formulated in poly-ε-caprolactone against Neospora caninum infection in mice.Q54335589
Immunoblot diagnosis of infection with Neospora caninum in cattle based on recombinant NcSAG4 Antigen.Q54367783
The differentiation of transcription between tachyzoites and bradyzoites of in vitro cultured Neospora caninum.Q54525033
Coyotes (Canis latrans) are definitive hosts of Neospora caninum.Q54724705
Cyclic transmission of Neospora caninum : serological findings in dogs shedding oocystsQ57051388
In vitro Development of Neospora caninum (Protozoa: Apicomplexa) from DogsQ58709203
Transgenic Neospora caninum strains constitutively expressing the bradyzoite NcSAG4 protein proved to be safe and conferred significant levels of protection against vertical transmission when used as live vaccines in miceQ61235758
Toxoplasma gondii: DNA vaccination with bradyzoite antigens induces protective immunity in mice against oral infection with parasite cystsQ61896263
Exogenous nitric oxide triggers Neospora caninum tachyzoite-to-bradyzoite stage conversion in murine epidermal keratinocyte cell culturesQ62564544
Interferon-gamma and interleukin-12 mediate protection to acute Neospora caninum infection in BALB/c miceQ73296745
Cellular immune responses in cattle experimentally infected with Neospora caninumQ78167211
A role for balance of interferon-gamma and interleukin-4 production in protective immunity against Neospora caninum infectionQ79165731
Natural killer cells act as early responders in an experimental infection with Neospora caninum in calvesQ79450546
P433issue2
P921main subjectNeospora caninumQ1431408
P304page(s)655-663
P577publication date2012-11-15
P1433published inParasitology ResearchQ15755242
P1476titleComparative study of protective activities of Neospora caninum bradyzoite antigens, NcBAG1, NcBSR4, NcMAG1, and NcSAG4, in a mouse model of acute parasitic infection
P478volume112

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cites work (P2860)
Q41550534A vaccine formulation combining rhoptry proteins NcROP40 and NcROP2 improves pup survival in a pregnant mouse model of neosporosis.
Q38655231Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models
Q90542230Canine neosporosis: perspectives on pathogenesis and management
Q38199260Control options for Neospora caninum--is there anything new or are we going backwards?
Q39299414Review on the immunological and molecular diagnosis of neosporosis (years 2011-2016).

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