Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines (scientific article published in June 2000)

Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.

Q33808930

Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site

Q33927628

Benzodiazepines.

Q38195197

Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

Q42279930

Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor

Q42544054

Pharmacologic and behavioral responses of inbred C57BL/6J and strain 129/SvJ mouse lines

Q42602275

Recombinant GABAA receptor function and ethanol

Q48267001

Ligand-dependent effects of ethanol and diethylether at brain benzodiazepine receptors

Q48453006

Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics

Q48746857

Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity

Q49096683

Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit

Q49161509

Anesthetic potencies of secondary alcohol enantiomers.

Q51797640

Immunocytochemical localization of gamma 2 short and gamma 2 long subunits of the GABAA receptor in the rat brain

Q72816662

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

371-374

P577

publication date

2000-06-01

P1433

published in

Pharmacology, Biochemistry and Behavior

Q15716554

P1476

title

Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines

P478

volume

Reverse relations

cites work (P2860)

Q48243676	Absence of anxiolytic response to chlordiazepoxide in two common background strains exposed to the elevated plus-maze: importance and implications of behavioural baseline
Q43257027	Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone
Q33953763	Alternative RNA splicing in the nervous system
Q35556217	Alternative splicing in the nervous system: an emerging source of diversity and regulation
Q48304837	Association study of GABRG2 polymorphisms with suicidal behaviour in schizophrenia patients with alcohol use disorder
Q40620867	Cloning and Characterization of a GABAA Receptor γ2 Subunit Variant
Q48615603	Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour
Q34749269	Drug interactions at GABA(A) receptors
Q34204921	GABA(A) receptor subtypes: dissecting their pharmacological functions
Q24801914	GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines.
Q39884127	Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes.
Q39418520	Global detection and identification of developmental stage specific transcripts in mouse brain using subtractive cross-screening algorithm
Q37146444	Impaired surface αβγ GABA(A) receptor expression in familial epilepsy due to a GABRG2 frameshift mutation
Q24608968	International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update
Q38043400	Mammalian sleep genetics
Q24683082	Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer
Q38190472	The behavioral pharmacology of zolpidem: evidence for the functional significance of α1-containing GABA(A) receptors
Q34629333	The effects of midazolam and sevoflurane on the GABA(A) receptors with alternatively spliced variants of the γ2 subunit
Q35202929	The neurobiology and control of anxious states
Q58712240	γ2 GABAR Trafficking and the Consequences of Human Genetic Variation

P356	DOI	10.1016/S0091-3057(00)00225-2
P698	PubMed publication ID	10880692