Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

scientific article published in July 2000

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. is …
instance of (P31):
scholarly articleQ13442814

External links are
P698PubMed publication ID10910034

P2093author name stringLi H
Liu L
Zhu B
Thompson WJ
Fetter J
Pamukcu R
Piazza GA
Ahnen D
Sperl G
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)3338-3342
P577publication date2000-07-01
P1433published inCancer ResearchQ326097
P1476titleExisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin
P478volume60

Reverse relations

cites work (P2860)
Q895382874E-BP1Thr46 Phosphorylation Association with Poor Prognosis in Quantitative Phosphoproteomics of Portal Vein Tumor Thrombus Revealed that 4E-BP1Thr46 Phosphorylation is Associated with Poor Prognosis in HCC
Q33390197A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state
Q35582287A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.
Q36537864A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity
Q34525861A phase I study of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors potentially responsive to mitoxantrone
Q36854046Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
Q39552261Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on hum
Q34808083Bacterial enterotoxins are associated with resistance to colon cancer.
Q40286688Biochemical (Prostate-Specific Antigen) Relapse: An Oncologist's Perspective.
Q44445074Biochemical (Prostate-Specific Antigen) Relapse: An Oncologist's Perspective.
Q38123175COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs
Q42176198Ca2+/calmodulin‐stimulated PDE1 regulates the beta‐catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells
Q39199574Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells
Q27023845Chemoprevention in familial adenomatous polyposis
Q35859243Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention
Q42135630Colon Tumor Cell Growth–Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition
Q42277641Colorectal cancer is a paracrine deficiency syndrome amenable to oral hormone replacement therapy
Q48550061Cyclic-GMP-Elevating Agents Suppress Polyposis in ApcMin mice by Targeting the Preneoplastic Epithelium
Q36602684Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Q28168895Effect of nonsteroidal anti-inflammatory drugs on beta-catenin protein levels and catenin-related transcription in human colorectal cancer cells
Q26829126Emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer
Q54301069Expression of cGMP-dependent protein kinase, PKGIα, PKGIβ, and PKGII in malignant and benign breast tumors.
Q28254667GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease
Q36830763GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases
Q36526265Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells.
Q38900900H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway
Q36202841Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine.
Q38802590Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers
Q28193048Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells
Q35151018Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells
Q40579631Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089.
Q35449858Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma
Q33352757Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480.
Q38169133NSAIDs inhibit tumorigenesis, but how?
Q38974324NSAIDs: Old Drugs Reveal New Anticancer Targets.
Q42775840National Cancer Institute workshop on chemopreventive properties of nonsteroidal anti-inflammatory drugs: role of COX-dependent and -independent mechanisms
Q38034670New NSAID targets and derivatives for colorectal cancer chemoprevention.
Q53249505New approaches to the treatment of advanced prostate cancer.
Q36808335Nexavar/Stivarga and viagra interact to kill tumor cells
Q38837269Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression
Q36637814Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases
Q36808317OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies
Q55457391Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas.
Q35827798PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Q39721627PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.
Q37395863Pharmacological modulation of cytotoxicity and cellular uptake of anti-cancer drugs by PDE5 inhibitors in lung cancer cells
Q46078166Phase I clinical trial of weekly docetaxel and exisulind, a novel inducer of apoptosis
Q36924607Phase I/II study of vinorelbine and exisulind as first-line treatment of advanced non-small cell lung cancer in patients at least 70 years old: a wisconsin oncology network study
Q42378330Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling
Q34416260Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity
Q36503940Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment
Q47171803Phosphodiesterase type 5 and cancers: progress and challenges
Q36215141Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia
Q47138288Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer
Q35597651Prevention and management of duodenal polyps in familial adenomatous polyposis
Q39922850Receptor guanylyl cyclase C (GC-C): regulation and signal transduction
Q34289307Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs
Q34234828Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs
Q55247585Repurposing drugs in oncology (ReDO)-selective PDE5 inhibitors as anti-cancer agents.
Q36952021Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants
Q34241272Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells
Q84159289Sex modulates intestinal transformation by the tumor-suppressor GCC
Q35108211Sex modulates intestinal transformation by the tumor-suppressor GCC.
Q36782452Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95
Q53187152Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.
Q36420145Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo
Q38724210Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells
Q35760255Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study
Q35020902Stabilization of cGMP-dependent protein kinase G (PKG) expression in vascular smooth muscle cells: contribution of 3'UTR of its mRNA
Q24794243Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients
Q37238527Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling
Q28479206Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα
Q33585342Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G
Q28166679Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines
Q36413785Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.
Q37167091Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.
Q35142855Targeted therapy for lung cancer
Q91928988Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs
Q58798789The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia
Q36458158The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma
Q33768672The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer
Q37693485The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment
Q33748280Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma
Q47104845Validation of PDE5 as a Chemoprevention Target
Q34765533cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression
Q34244951cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action

Search more.