Involvement of direct inhibition of NMDA receptors in the effects of sigma-receptor ligands on glutamate neurotoxicity in vitro

scientific article published in September 2000

Involvement of direct inhibition of NMDA receptors in the effects of sigma-receptor ligands on glutamate neurotoxicity in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0014-2999(00)00595-1
P698PubMed publication ID10980261

P50authorShuji KanekoQ42606230
P2093author name stringNishikawa H
Katsuki H
Kume T
Akaike A
Hashino A
P2860cites workExon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor geneQ24336001
Purification, molecular cloning, and expression of the mammalian sigma1-binding siteQ24619317
Cloning and characterization of a mouse sigma1 receptor.Q32062674
Cloning and functional characterization of a sigma receptor from rat brain.Q32104855
The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemiaQ34290141
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampusQ34377109
Binding properties of SA4503, a novel and selective sigma 1 receptor agonistQ34398012
Sigma receptors: from molecule to man.Q36407558
Nitric oxide mediates glutamate neurotoxicity in primary cortical culturesQ37552767
Sigma binding sites in the brain; an emerging concept for multiple sites and their relevance for psychiatric disordersQ37897361
Excitotoxins: a possible new mechanism for the pathogenesis of ischemic retinal damageQ38340826
Regulation by neuroprotective factors of NMDA receptor mediated nitric oxide synthesis in the brain and retinaQ40610040
PPBP [4-phenyl-1-(4-phenylbutyl) piperidine], a potent sigma-receptor ligand, decreases brain injury after transient focal ischemia in catsQ41666701
Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: protection by SKF 10,047.Q43776025
BMY-14802 protects against ischemia-induced neuronal damage in the gerbilQ44768668
(-)PPAP: a new and selective ligand for sigma binding sitesQ44949531
Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systemsQ46971835
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain culturesQ48281625
Haloperidol interacts with the strychnine-insensitive glycine site at the NMDA receptor in cultured mouse hippocampal neuronesQ48301290
Mechanisms of cholecystokinin-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicityQ48420883
Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemiaQ48518328
Sigma ligands stimulate GTPase activity in mouse prefrontal membranes: evidence for the existence of metabotropic sigma receptorQ48603850
BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neuronsQ48707605
Ameliorating effect of SA4503, a novel sigma 1 receptor agonist, on memory impairments induced by cholinergic dysfunction in ratsQ48863675
PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in ratsQ48882455
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.Q49158867
Effect of SA4503, a novel sigma1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons.Q50524780
Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism.Q52040573
Glutamate neurotoxicity in cortical cell culture.Q54412952
p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical culturesQ60688389
Sigma receptor modulation of noradrenergic-stimulated pineal melatonin biosynthesis in ratsQ71152161
Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal culturesQ72186610
Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studiesQ72347007
Prostaglandin E2 protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicityQ72587685
Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal culturesQ74576744
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectneurotoxicityQ3338704
toxic encephalopathyQ7830379
P304page(s)41-48
P577publication date2000-09-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleInvolvement of direct inhibition of NMDA receptors in the effects of sigma-receptor ligands on glutamate neurotoxicity in vitro
P478volume404

Reverse relations

cites work (P2860)
Q36976939A prototypical Sigma-1 receptor antagonist protects against brain ischemia
Q37172896Analysis of sigma receptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice
Q28215676Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro
Q34515209Drug interactions with patient-controlled analgesia
Q37383094Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PET
Q33238062Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation
Q34158143Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons.
Q35673122Review of the pharmacological and clinical profile of rimcazole.
Q34670217Sigma-1 receptors and animal studies centered on pain and analgesia
Q44211149Spreading depression: imaging and blockade in the rat neocortical brain slice
Q28204130Synthesis of Chiral 1-[ω-(4-Chlorophenoxy)alkyl]-4-methylpiperidines and Their Biological Evaluation at σ1, σ2, and Sterol Δ8−Δ7 Isomerase Sites
Q88410644Systematic review of the pharmacological agents that have been tested against spreading depolarizations
Q51750311The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Q35538511The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

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