RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

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RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-894X(01)00034-8
P698PubMed publication ID11266171

P2093author name stringPage KM
McLay IM
Halley F
Maslen C
Redford EJ
Souness JE
Foster ML
Collis AJ
Wilsher NE
P2860cites workA protein kinase involved in the regulation of inflammatory cytokine biosynthesisQ24311139
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ28842973
Computational methods for the prediction of 'drug-likeness'Q33826560
Molecular and cellular interactions in rheumatoid synovium.Q40940390
Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.Q42537136
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacyQ43542785
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritisQ73374754
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinaseQ77906539
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)693-696
P577publication date2001-03-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleRPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency
P478volume11

Reverse relations

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Q78881129Imidazopyrimidines, potent inhibitors of p38 MAP kinase
Q44563635Indole-based heterocyclic inhibitors of p38alpha MAP kinase: designing a conformationally restricted analogue
Q35911103Molecular targets in immune-mediated diseases: focus on rheumatoid arthritis
Q74257768Monitor: molecules and profiles
Q34502720Pharmacological inhibitors of MAPK pathways.
Q47121794Research advances in kinase enzymes and inhibitors for cardiovascular disease treatment.
Q79236264SAR of 3,4-Dihydropyrido[3,2-d]pyrimidone p38 inhibitors
Q35140855Therapeutic strategies for rheumatoid arthritis
Q44249286p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold

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