Early and progressive accumulation of reactive microglia in the Huntington disease brain

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Early and progressive accumulation of reactive microglia in the Huntington disease brain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JNEN/60.2.161
P698PubMed publication ID11273004

P50authorPradeep G BhideQ37372271
P2093author name stringUchiyama Y
Aronin N
DiFiglia M
Sapp E
Vonsattel JP
Tohyama K
Hashikawa T
Kegel KB
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Microglial and astrocytic cell responses in the rat hippocampus after an intracerebroventricular kainic acid injectionQ48281139
Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's diseaseQ48373983
Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration.Q48463886
Huntington disease.Q48465200
Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.Q48480334
The CNS acute inflammatory response to excitotoxic neuronal cell death.Q48648473
Inflammatory mechanisms and anti-inflammatory therapy in Alzheimer's disease.Q53214536
Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.Q53338394
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neuronsQ24317574
Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cellsQ24561696
Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposureQ28145614
Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed endsQ28238396
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutationQ28246858
Huntingtin interacts with a family of WW domain proteinsQ28279245
Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytesQ28910318
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brainsQ29616293
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brainQ29617982
Microglia: a sensor for pathological events in the CNSQ29620556
Proteasome inhibitors: valuable new tools for cell biologistsQ29620573
Developmental expression of mRNAs encoding thymosins beta 4 and beta 10 in rat brain and other tissuesQ33507918
Differential loss of striatal projection neurons in Huntington diseaseQ33637273
Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's diseaseQ34168124
Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cellsQ36472638
Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease: a quantitative Golgi study.Q36774484
Complement activation by beta-amyloid in Alzheimer diseaseQ37262889
Expression of thymosin beta 4 gene during Xenopus laevis embryogenesisQ38329321
Risk of Alzheimer's disease and duration of NSAID use.Q39457609
Mapping the binding site of thymosin beta4 on actin by competition with G-actin binding proteins indicates negative co-operativity between binding sites located on opposite subdomains of actinQ41833004
Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleusQ43814253
The cortical neuritic pathology of Huntington's diseaseQ45288549
Morphometric analysis of the prefrontal cortex in Huntington's diseaseQ45293165
Huntingtin localization in brains of normal and Huntington's disease patientsQ45295341
Neuronal and glial somal size in the prefrontal cortex: a postmortem morphometric study of schizophrenia and Huntington diseaseQ45295751
Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington diseaseQ45297318
Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysisQ45307235
Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesisQ46076651
Localization of thymosin beta 4 to the neural tissues during the development of Xenopus laevis, as studied by in situ hybridization and immunohistochemistryQ48105209
P433issue2
P921main subjectHuntington's diseaseQ190564
microgliaQ1622829
P304page(s)161-172
P577publication date2001-02-01
P1433published inJournal of Neuropathology & Experimental NeurologyQ15716771
P1476titleEarly and progressive accumulation of reactive microglia in the Huntington disease brain
P478volume60

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