Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.

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Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR. is …
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P356DOI10.1074/JBC.M008140200
P698PubMed publication ID11278390

P2093author name stringLi S
Koromilas AE
P2860cites workCharacterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinaseQ22010589
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeastQ24562926
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivoQ24563365
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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeastQ27931508
Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKRQ28143707
The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitroQ28144828
Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homologQ28290296
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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR.Q31778073
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The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death?Q33703352
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.Q33811639
Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.Q33886085
Proteins binding to duplexed RNA: one motif, multiple functionsQ33899394
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2Q33996300
Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cellsQ34461967
Structural features of adenovirus 2 virus-associated RNA required for binding to the protein kinase DAI.Q34888248
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKRQ35273064
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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinaseQ36039597
Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformationQ36551384
Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiaeQ36566913
Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.Q36569456
Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).Q38362637
The double-stranded RNA-binding protein X1rbpa promotes RNA strand annealing.Q39725209
A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.Q40430436
A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.Q40446145
Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infectionQ40863327
A diminished activation capacity of the interferon-inducible protein kinase PKR in human T lymphocytesQ40894610
The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.Q40996380
Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated regionQ41011133
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinaseQ41602853
The double-stranded RNA-dependent protein kinase PKR: structure and functionQ41614652
Functional characterization of the RNA-binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR).Q42686037
Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cellsQ42828005
The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ GeneQ52205320
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.Q52533947
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)13881-13890
P577publication date2001-02-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleDominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.
P478volume276