Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway

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Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M008802200
P698PubMed publication ID11278437
P5875ResearchGate publication ID12055896

P2093author name stringLi S
Patterson C
Runge MS
Madamanchi NR
P2860cites workAngiotensin II-induced tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated by Janus-activated kinase 2 and Fyn kinases and mitogen-activated protein kinase phosphatase 1.Q38331607
Differential accumulation of mRNA for immediate early genes and heat shock genes in heart after ischaemic injuryQ38357071
Cellular consequences of thrombin-receptor activationQ40952373
Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vectorQ40973614
Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophyQ41008448
Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT1 receptorQ41049990
Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinasesQ41175767
The role of the 90-kDa heat shock protein in cell cycle control and differentiation of the monoblastoid cell line U937.Q41179841
JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells.Q41197797
The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptorsQ41729150
Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cellsQ42449845
Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cellsQ43883726
The effects of thrombin on bovine aortic endothelial and smooth muscle cellsQ44826231
Thrombin aivation of the 9E3/CEF4 chemokine involves tyrosine kinases including c-src and the epidermal growth factor receptorQ46691688
Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and diseaseQ47756415
Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migrationQ47769116
Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation.Q53724601
Angiotensin II Controls p21 Activity via pp60Q57630605
Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle CellsQ57908184
Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathwayQ22253244
Protease-activated receptor 3 is a second thrombin receptor in humansQ24310957
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationQ24337851
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cellsQ27860607
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cellsQ28244421
Jak2 is essential for signaling through a variety of cytokine receptorsQ28270987
A dual thrombin receptor system for platelet activationQ28280578
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promotersQ28293210
Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptorQ28301248
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytesQ28377588
Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cellsQ28378269
Requirement of serine phosphorylation for formation of STAT-promoter complexesQ28637366
Protein folding in the cellQ29547792
Requirement for generation of H2O2 for platelet-derived growth factor signal transductionQ29615245
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptorQ30449306
Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebratesQ30846862
Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine inductionQ30976301
Janus kinases and their role in growth and diseaseQ33664276
Physiological significance of STAT proteins: investigations through gene disruption in vivoQ33754086
Negative regulators of cytokine signal transductionQ33754091
Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]Q33960774
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.Q34329668
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responsesQ34468309
The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicityQ34654146
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinasesQ36307242
Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptorQ37383530
Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heartQ38327825
JunB forms the majority of the AP-1 complex and is a target for redox regulation by receptor tyrosine kinase and G protein-coupled receptor agonists in smooth muscle cellsQ38327919
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
P304page(s)18915-18924
P577publication date2001-03-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleThrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway
P478volume276