CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells

scientific article published in March 2002

CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1074-7613(02)00290-X
P698PubMed publication ID11911825

P50authorMatthias G von HerrathQ88828481
Stephen SchoenbergerQ58385799
P2093author name stringDirk Homann
Anna Hughes
Marianne J B van Stipdonk
Angelika Jahreis
Bryan Coon
Tom Wolfe
Kiley R Prilliman
P2860cites workDendritic cells and the control of immunityQ27860918
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimenQ28141785
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subsetQ28290931
The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cellsQ30468363
Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigensQ30990189
Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosisQ33835268
Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responsesQ33971036
Interferons alpha and beta as immune regulators--a new lookQ34289965
Type 1 diabetes: new perspectives on disease pathogenesis and treatmentQ34321603
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouseQ36364541
Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsetsQ73785333
Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cellsQ73838320
A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesisQ73966607
Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCRQ74286685
Cytotoxic activity of human dendritic cells is differentially regulated by double-stranded RNA and CD40 ligandQ74532600
Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivoQ77323598
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primatesQ77890140
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosisQ36366458
Models of T cell anergy: is there a common molecular mechanism?Q36366967
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identifiedQ36367631
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progressionQ36368539
Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)Q36375450
Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitusQ36376535
Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanismQ36380421
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.Q36417432
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosisQ37696199
Dendritic cells acquire antigens from live cells for cross-presentation to CTL.Q40822225
Induction of immunologic tolerance for transplantationQ40827011
A subset of cytolytic dendritic cells in rat.Q40848495
The immunoregulatory effects of NK cells: the role of TGF-beta and implications for autoimmunityQ41654453
Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.Q41700461
Functional expression of B7/BB1 on activated T lymphocytesQ41898118
CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.Q41898717
Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter systemQ41932073
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapyQ42675165
Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell functionQ42767949
Blockade of CD40 ligand suppresses chronic experimental myasthenia gravis by down-regulation of Th1 differentiation and up-regulation of CTLA-4.Q43612872
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune responseQ43986613
Regulation of adaptive immunity by natural killer cellsQ45112156
Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.Q45739717
Neither B lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes.Q45739869
NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cellsQ45744756
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic modelQ45783598
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic miceQ45854348
Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses.Q45969254
Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memoryQ46347403
Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetesQ46495737
Treatment of murine lupus with CTLA4IgQ46538983
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactionsQ47982736
Help for cytotoxic-T-cell responses is mediated by CD40 signallingQ47982749
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cellQ47982760
The development, maturation, and turnover rate of mouse spleen dendritic cell populations.Q52143353
CD8+ T Cells Rapidly Acquire NK1.1 and NK Cell-Associated Molecules Upon Stimulation In Vitro and In VivoQ56953519
Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic CellsQ58235001
Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation ToleranceQ61651670
Human natural killer (NK) cells present staphylococcal enterotoxin B (SEB) to T lymphocytesQ71068093
Phenotypic and functional characterization of CD11c+ dendritic cell population in mouse Peyer's patchesQ71420915
Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40Q72093299
Anti-CD154 (CD40L) prevents recurrence of diabetes in islet isografts in the DR-BB ratQ73033716
Suppression of murine thyroiditis via blockade of the CD40-CD40L interactionQ73347843
Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cellsQ73505005
Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulationQ73679954
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)403-415
P577publication date2002-03-01
P1433published inImmunityQ6005457
P1476titleCD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells
P478volume16