scholarly article | Q13442814 |
P2093 | author name string | S Noguchi | |
Y Miyoshi | |||
C Egawa | |||
K Iwao | |||
P2860 | cites work | Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1 | Q24321907 |
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines | Q28239817 | ||
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2 | Q28265518 | ||
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation | Q28285317 | ||
Genetic instability in colorectal cancers | Q29618711 | ||
p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers. | Q51109193 | ||
P433 | issue | 3 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 370-373 | |
P577 | publication date | 2001-05-01 | |
P1433 | published in | International Journal of Cancer | Q332492 |
P1476 | title | Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers | |
P478 | volume | 92 |
Q42174912 | A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis |
Q34694095 | A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer |
Q40305921 | AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer |
Q27824792 | AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol |
Q40300906 | Aberrant expression of CHFR in malignant peripheral nerve sheath tumors |
Q33187451 | Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes. |
Q79401919 | Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas |
Q37592390 | Assessment of the in vivo antitumor effects of ENMD-2076, a novel multitargeted kinase inhibitor, against primary and cell line-derived human colorectal cancer xenograft models |
Q54327271 | Association between the STK15 polymorphisms and risk of cancer: a meta-analysis. |
Q46349825 | Association of loss of BRCA1 expression with centrosome aberration in human breast cancer |
Q41956365 | Astrin regulates Aurora-A localization. |
Q37035855 | AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128 |
Q53307778 | Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers. |
Q24318115 | Aurora A, centrosome structure, and the centrosome cycle |
Q37157724 | Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma |
Q38953487 | Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer |
Q34029020 | Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT. |
Q35998764 | Aurora-A - a guardian of poles |
Q26771371 | Aurora-A Kinase as a Promising Therapeutic Target in Cancer |
Q53515244 | Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. |
Q36627355 | Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians |
Q34599715 | Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer |
Q36084311 | Aurora-A is an efficient marker for predicting poor prognosis in human nasopharyngeal carcinoma with aggressive local invasion: 208 cases with a 10-year follow-up from a single institution. |
Q40204662 | Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway |
Q54511715 | Aurora-A kinase nuclear expression in chronic lymphocytic leukemia. |
Q34798251 | Aurora-A kinase-inactive mutants disrupt the interaction with Ajuba and cause defects in mitotic spindle formation and G2/M phase arrest in HeLa cells |
Q37613047 | Aurora-A kinase: a novel target both for cellular immunotherapy and molecular target therapy against human leukemia |
Q33517958 | Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway |
Q35968406 | Aurora-kinase inhibitors as anticancer agents |
Q30558181 | Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic cells |
Q38427906 | Breakpoint characterization of the der(19)t(11;19)(q13;p13) in the ovarian cancer cell line SKOV-3. |
Q34334059 | Can the centrosome be a marker for DNA ploidy in breast cancer? |
Q28611400 | Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards |
Q28215502 | Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1 |
Q33349886 | Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC). |
Q34818152 | Centrosome amplification and the development of cancer |
Q35959371 | Centrosome amplification and the origin of chromosomal instability in breast cancer |
Q24534950 | Centrosome amplification drives chromosomal instability in breast tumor development |
Q35801868 | Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase |
Q47773710 | Chromosomal instability in osteosarcoma and its association with centrosome abnormalities |
Q40399348 | Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis |
Q57274907 | Common and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes |
Q33836953 | Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein |
Q33300353 | Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer |
Q33952284 | Control of centrin stability by Aurora A. |
Q45103581 | Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models |
Q27639665 | Crystal structure of aurora-2, an oncogenic serine/threonine kinase |
Q57244875 | Epothilones and new analogues of the microtubule modulators in taxane-resistant disease |
Q39705410 | Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide |
Q28572162 | Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats |
Q39961166 | Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer |
Q34491749 | Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients |
Q53013674 | Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer. |
Q33835928 | FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells. |
Q46284220 | Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene |
Q24802613 | Finding the needle in the haystack: why high-throughput screening is good for your health |
Q33647697 | Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions |
Q35123861 | Function and regulation of Aurora/Ipl1p kinase family in cell division |
Q39506267 | Functional significance of Aurora kinase A regulatory interactions with p53-ERα complex in human breast cancer cells |
Q51599172 | Gene expression profiles of microdissected pancreatic ductal adenocarcinoma. |
Q55519458 | Gene expression profiles of the aurora family kinases. |
Q35267773 | Generation and characterization of novel monoclonal antibodies against human aurora-A. |
Q40624764 | Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231 |
Q53203084 | Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in two of the most relevant gynaecological tumor entities. |
Q33265521 | Heterogeneity of mammary lesions represent molecular differences |
Q34322087 | Histone modification enzymes: novel targets for cancer drugs |
Q38584527 | How to be good at being bad: centrosome amplification and mitotic propensity drive intratumoral heterogeneity |
Q38630091 | Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A |
Q36957842 | Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression |
Q24304083 | Identification of Ski as a target for Aurora A kinase |
Q28189663 | Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human |
Q30758961 | Identification of differentially expressed genes in immortalized human bronchial epithelial cell line as a model for in vitro study of lung carcinogenesis |
Q90341131 | Insights into the non-mitotic functions of Aurora kinase A: more than just cell division |
Q34186981 | Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation |
Q54498929 | MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. |
Q38115166 | Mitosis as an anti-cancer drug target |
Q33926467 | Mitotic chromosomal instability and cancer: mouse modelling of the human disease. |
Q37611227 | Molecular and cell biology of testicular germ cell tumors |
Q24801662 | Mutations in normal breast tissue and breast tumours |
Q53088760 | NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies. |
Q47547178 | Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer |
Q42708398 | Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities |
Q36615322 | Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability |
Q36462861 | Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC). |
Q46916025 | Pharmacogenetic profiling of Aurora kinase B is associated with overall survival in metastatic colorectal cancer |
Q24306319 | Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A |
Q45345467 | Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. |
Q39824320 | Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen |
Q38848857 | Preclinical testing of selective Aurora kinase inhibitors on a medullary thyroid carcinoma-derived cell line. |
Q36521963 | Predictive factors for response to docetaxel in human breast cancers |
Q40666306 | Preparation and characterization of a human aurora-A kinase monoclonal antibody |
Q43692538 | Prognostic value of proliferation markers expression in breast cancer |
Q54478536 | Prospective assessment of XRCC3, XPD and Aurora kinase A single-nucleotide polymorphisms in advanced lung cancer. |
Q37300960 | Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase |
Q41557933 | Regulation of microtubule, apoptosis, and cell cycle-related genes by taxotere in prostate cancer cells analyzed by microarray |
Q40336291 | STK15 gene overexpression, centrosomal amplification, and chromosomal instability in the absence of STK15 mutations in laryngeal carcinoma |
Q38449482 | STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis |
Q26784060 | Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer |
Q27640105 | Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography |
Q34831438 | Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion |
Q48145155 | Synthesis and structure elucidation of polyphenols containing the N'-methyleneformohydrazide scaffold as aurora kinase inhibitors |
Q24299319 | TACC1-chTOG-Aurora A protein complex in breast cancer |
Q42723757 | Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment |
Q35971862 | The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis |
Q37411001 | The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes |
Q24515254 | The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis |
Q40772862 | The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A. |
Q24540283 | The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1. |
Q37167047 | The potential role of Aurora kinase inhibitors in haematological malignancies |
Q38979464 | The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism |
Q39971127 | Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1. |
Q38259322 | Triple-negative breast cancer: investigating potential molecular therapeutic target |
Q34152070 | Update on anaplastic thyroid carcinoma: morphological, molecular, and genetic features of the most aggressive thyroid cancer |
Q34300737 | VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo |