Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro

scientific article

Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JNR.1093
P698PubMed publication ID11340649

P2093author name stringO García
L Massieu
P2860cites workInhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical culturesQ71507107
Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanismQ71655959
Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonateQ71689201
Resuscitation of brain neurons in the presence of Ca2+ after toxic NMDA-receptor activityQ71702080
Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studiesQ71706004
Selective neurotoxicity of ruthenium red in primary culturesQ71706146
NMDA Receptor Activation Produces Concurrent Generation of Nitric Oxide and Reactive Oxygen Species: Implications for Cell DeathQ71832406
Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis studyQ72169616
Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatumQ72901520
3-Nitropropionic acid: an astrocyte-sparing neurotoxin in vitroQ73342059
Oxidative stress during energy impairment in mesencephalic cultures is not a downstream consequence of a secondary excitotoxicityQ73466814
Neuroprotective effects of creatine administration against NMDA and malonate toxicityQ73571747
In vivo potentiation of glutamate-mediated neuronal damage after chronic administration of the glycolysis inhibitor iodoacetateQ74332185
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.Q30978603
Mitochondria in neurodegeneration: bioenergetic function in cell life and deathQ33541512
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial functionQ34296896
3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum.Q36723864
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's diseaseQ36976707
ATP and brain functionQ38597443
Excitatory amino acid-induced alterations of cytoplasmic free Ca2+ in individual cerebellar granule neurons: role in neurotoxicityQ39243523
3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms.Q39449440
The role of neuronal energy in the neurotoxicity of excitatory amino acidsQ39523207
Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reducedQ39531608
Evidence that the loss of the voltage-dependent Mg2+ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolismQ41096804
Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reductionQ41549753
K(+)-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na+.Q41682921
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acidQ41711372
Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.Q46066087
Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomerQ46602656
Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicityQ48098641
Ions and energy in mammalian brainQ48133714
Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices.Q48187773
NMDA-dependent superoxide production and neurotoxicityQ48234286
Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impairedQ48307959
Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.Q48340892
Metabolic control of kynurenic acid formation in the rat brainQ48371421
Ketone bodies and brain glutamate and GABA metabolismQ48371462
Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: reversal by lactate and pyruvateQ48387377
Metabolic inhibition potentiates AMPA-induced Ca2+ fluxes and neurotoxicity in rat cerebellar granule cellsQ48528691
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisQ48609930
Glutamate Neurotoxicity Is Independent of Calpain I Inhibition in Primary Cultures of Cerebellar Granule CellsQ48651242
Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cellsQ48720755
The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical culturesQ48923863
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemiaQ49105194
The competitive transport inhibitor L-trans-pyrrolidine-2, 4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition.Q51562635
Glutamate release in severe brain ischaemia is mainly by reversed uptake.Q51977738
AMPA neurotoxicity in cultured cerebellar granule neurons: mode of cell death.Q53995482
Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β-Amyloid in Rat Hippocampal NeuronsQ58829455
Lactate-Supported Synaptic Function in the Rat Hippocampal Slice PreparationQ68381532
Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseasesQ71201898
P433issue4
P304page(s)418-428
P577publication date2001-05-01
P1433published inJournal of Neuroscience ResearchQ6295654
P1476titleStrategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro
P478volume64

Reverse relations

cites work (P2860)
Q44532198Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition.
Q46873531Antioxidant activity, cellular bioavailability, and iron and calcium management of neuroprotective and nonneuroprotective flavones
Q48290603Cerebellar granule neurons are more vulnerable to transient transport-mediated glutamate release than to glutamate uptake blockade. correlation with excitatory amino acids levels.
Q48364448D-beta-hydroxybutyrate prevents glutamate-mediated lipoperoxidation and neuronal damage elicited during glycolysis inhibition in vivo
Q43942172Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy
Q44675700Glutamate uptake inhibitor L-trans-pyrrolidine 2,4-dicarboxylate becomes neurotoxic in the presence of subthreshold concentrations of mitochondrial toxin 3-nitropropionate: involvement of mitochondrial reducing activity and ATP production
Q44327958Influence of serum-free medium on the expression of glutamate transporters and the susceptibility to glutamate toxicity in cultured cortical neurons.
Q34971377Ketogenic diets: evidence for short- and long-term efficacy
Q37590056Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period
Q43832585N-Acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier
Q24646914Neuroprotective and disease-modifying effects of the ketogenic diet
Q43780991Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates
Q34464744Pyruvate carboxylation in neurons
Q48547164Veratridine, but not elevated K+, inhibits excitatory amino acid transporter activity in rat hippocampal slices.

Search more.