Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways

scientific article

Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M103213200
P698PubMed publication ID11350975

P2093author name stringZeng H
Dvorak HF
Mukhopadhyay D
P433issue29
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)26969-26979
P577publication date2001-05-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleVascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways
P478volume276

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cites work (P2860)
Q37622288"Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment
Q361218672,3,7,8-Tetrachlorodibenzo-p-dioxin differentially suppresses angiogenic responses in human placental vein and artery endothelial cells
Q60301465A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis
Q34333820A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1
Q24559732A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters
Q96136180ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation
Q47277760Activated Ras induces a proangiogenic phenotype in primary endothelial cells
Q34635176Aflibercept in the treatment of metastatic colorectal cancer
Q46775274Altered VEGF-A and receptor mRNA expression profiles, and identification of VEGF144 in foetal rat calvaria cells, in coculture with microvascular endothelial cells
Q40549904An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1.
Q73228269Angiogenesis in hematology: a field of active research
Q36230890Angiogenesis: update 2005.
Q44883177Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production
Q34974876Antiangiogenic agents targeting vascular endothelial growth factor and its receptors in clinical development
Q47649124Antitumor effects of Tubeimoside-1 in NCI-H1299 cells are mediated by microRNA-126-5p-induced inactivation of VEGF-A/VEGFR-2/ERK signaling pathway
Q34443661Autocrine VEGF signaling is required for vascular homeostasis
Q38011768Beyond bevacizumab: new anti-VEGF strategies in colorectal cancer
Q47611649CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island
Q85015061Cancer of the corpus uteri
Q53322874Cancer of the corpus uteri.
Q89910525Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models
Q58449597Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling
Q35949632Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling
Q28579494Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation
Q28575727Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway
Q36392576Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production.
Q33995228Cytotoxicity of VEGF(121)/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2
Q56815794DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration
Q35884110DNA conjugated SWCNTs enter endothelial cells via Rac1 mediated macropinocytosis
Q40178858Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration
Q24302190Development of a highly-potent anti-angiogenic VEGF8-109 heterodimer by directed blocking of its VEGFR-2 binding site
Q36844669Differential effects of cyclic and static stretch on coronary microvascular endothelial cell receptors and vasculogenic/angiogenic responses
Q35764454Differential expression of vascular endothelial growth factor (VEGF), endocrine gland derived-VEGF, and VEGF receptors in human placentas from normal and preeclamptic pregnancies
Q34365504Differential regulation of orphan nuclear receptor TR3 transcript variants by novel vascular growth factor signaling pathways
Q57116380Dihydroartemisinin enhances VEGFR1 expression through up-regulation of ETS-1 transcription factor
Q24312658Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways
Q41891694Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting
Q51642790Effect of oxygen and glucose deprivation on VEGF and its receptors in microvascular endothelial cells co-cultured with mast cells.
Q43189547Embryonic vasculogenesis and hematopoietic specification
Q38065241Emerging VEGF-receptor inhibitors for colorectal cancer
Q35974766Exendin-4 protects HUVECs from t-BHP-induced apoptosis via PI3K/Akt-Bcl-2-caspase-3 signaling
Q47395346Expression and Function of the Vascular Endothelial Growth Factor Receptor FLT-1 in Human Eosinophils
Q33769685Expression of circulating vascular endothelial growth factor-antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease
Q34439734Fast rearrangement of the neuronal growth cone's actin cytoskeleton following VEGF stimulation
Q37231437Fine-tuning the angiogenic response to vascular endothelial growth factor
Q40765930Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1.
Q34717950Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms.
Q50123361From biology to therapy: Improvements of therapeutic options in Lung cancer.
Q93185552Fruquintinib: a novel antivascular endothelial growth factor receptor tyrosine kinase inhibitor for the treatment of metastatic colorectal cancer
Q35937557Gene transfer for therapeutic vascular growth in myocardial and peripheral ischemia
Q36021580Genetic and hypoxic regulation of angiogenesis in gliomas
Q35568152Growing and shaping the vascular tree: multiple roles for VEGF
Q28290402Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells
Q28180577Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo
Q83979034Hypoxia effects on proangiogenic factors in human umbilical vein endothelial cells: functional role of the peptide somatostatin
Q36321428Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins
Q56892691Inhibition of tumor angiogenesis in lung cancer by T4 phage surface displaying mVEGFR2 vaccine
Q51131994Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle.
Q24632703Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer
Q38008362Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation
Q43740142LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking.
Q26775043Lenvatinib: Role in thyroid cancer and other solid tumors
Q34331369Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A
Q24302083Magic roundabout, a tumor endothelial marker: expression and signaling
Q52767617Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells.
Q36475841MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.
Q47952830Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells
Q34566028Molecular and functional diversity of vascular endothelial growth factors
Q36010234NHERF-2 maintains endothelial homeostasis
Q47666008Neocortical developmental analysis of vasculature and their growth factors offer new insight into fragile X syndrome abnormalities.
Q38349883Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell Migration
Q34847842Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin β4
Q36228417Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity
Q54682241Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease.
Q64379300PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects
Q37986561Patients with metastatic breast cancer using bevacizumab as a treatment: is there still a role for it?
Q28285900Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
Q43867569Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
Q34292149Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors
Q38647883Precise scheduling of chemotherapy primes VEGF-producing tumors for successful systemic oncolytic virotherapy
Q36281111Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets
Q44445189Regulation of 1-alpha, 25-dihydroxyvitamin D3 on interleukin-6 and interleukin-8 induced by sulfur mustard (HD) on human skin cells
Q35757924Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis
Q40669797Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line
Q34031787Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes
Q40618771Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells
Q24304277Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Q34239172Selective assembly of DNA-conjugated single-walled carbon nanotubes from the vascular secretome
Q37362646Single-molecule detection of H₂O₂ mediating angiogenic redox signaling on fluorescent single-walled carbon nanotube array
Q44643921Snake Venom Vascular Endothelial Growth Factors (VEGFs) Exhibit Potent Activity through Their Specific Recognition of KDR (VEGF Receptor 2)
Q55008337Targeting VEGF/VEGFR to Modulate Antitumor Immunity.
Q50216101The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction
Q54321577The corpora lutea proangiogenic state of VEGF system components is turned to antiangiogenic at the later phase of the oestrous cycle in cows.
Q35083393The impact of gender on progression of renal disease: potential role of estrogen-mediated vascular endothelial growth factor regulation and vascular protection
Q24538981The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
Q35116734The merits of vascular targeting for gynecologic malignancies
Q38462638The role of anti-angiogenesis in non-small-cell lung cancer: an update
Q36907325The role of vascular endothelial growth factor in the pathogenesis, diagnosis and treatment of malignant pleural effusion
Q35098106The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation
Q36682884The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.
Q35418973Therapeutic advances in women's cancers
Q41775575Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells
Q28578381VEGF links hippocampal activity with neurogenesis, learning and memory
Q29617256VEGF receptor signalling - in control of vascular function
Q90698963VEGF receptor-1 modulates amyloid β 1-42 oligomer-induced senescence in brain endothelial cells
Q44043571VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
Q53305892VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: role in VEGF-induced angiogenesis.
Q50125265VEGF, FGF-2 and TGFβ expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles
Q34480730VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling
Q35296110VEGF-receptor signal transduction
Q36949564VEGF: an essential mediator of both angiogenesis and endochondral ossification
Q34333828VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy
Q35585704VEGFR-1 overexpression identifies a small subgroup of aggressive prostate cancers in patients treated by prostatectomy
Q37358053Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways
Q24297590Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
Q35919917Vascular endothelial growth factor and the nervous system.
Q35939630Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer.
Q24305184Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines
Q35049227Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials.
Q36371903Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis
Q36672598Yeast-derived beta-glucan augments the therapeutic efficacy mediated by anti-vascular endothelial growth factor monoclonal antibody in human carcinoma xenograft models