Human immunodeficiency virus reverse transcriptase displays a partially processive 3‘ to 5‘ endonuclease activity

scientific article published on December 25, 1991

Human immunodeficiency virus reverse transcriptase displays a partially processive 3‘ to 5‘ endonuclease activity is …
instance of (P31):
scholarly articleQ13442814

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P953full work available at URLhttp://intl.jbc.org/cgi/content/abstract/266/36/24295
https://api.elsevier.com/content/article/PII:S0021925818542277?httpAccept=text/plain
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P698PubMed publication ID1722202

P2093author name stringR. A. Bambara
L. M. Mallaber
P. J. Fay
DeStefano JJ
J. J. DeStefano
R. G. Buiser
P2860cites workRibonuclease H activities associated with viral reverse transcriptases are endonucleasesQ24614747
Linker insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domainQ33852475
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.Q34382153
HIV-1 RT-associated ribonuclease H displays both endonuclease and 3′----5′ exonuclease activityQ34557590
Mechanism of action of ribonuclease H isolated from avian myeloblastosis virus and Escherichia coliQ35096208
Studies on reverse transcriptase of RNA tumor viruses III. Properties of purified Moloney murine leukemia virus DNA polymerase and associated RNase HQ36533585
Involvement of retrovirus reverse transcriptase-associated RNase H in the initiation of strong-stop (+) DNA synthesis and the generation of the long terminal repeatQ36919004
Reconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptaseQ37396397
Degradation of DNA RNA hybrids by ribonuclease H and DNA polymerases of cellular and viral originQ37500396
Model RNA-directed DNA synthesis by avian myeloblastosis virus DNA polymerase and its associated RNase HQ39557503
RNA-primed initiation of Moloney murine leukemia virus plus strands by reverse transcriptase in vitroQ40133605
Duplex DNA binding activity of the avian myeloblastosis virus DNA polymeraseQ45802416
Mechanism of action of Moloney murine leukemia virus RNA-directed DNA polymerase associated RNase H (RNase H I).Q45805696
Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptaseQ45860312
Analysis of the ribonuclease H activity of HIV-1 reverse transcriptase using RNA.DNA hybrid substrates derived from the gag region of HIV-1Q69123482
Mechanism of release of the avian retrovirus tRNATrp primer molecule from viral DNA by ribonuclease H during reverse transcriptionQ72681023
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
cell biologyQ7141
P304page(s)24295-24301
P577publication date1991-12-01
1991-12-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleHuman immunodeficiency virus reverse transcriptase displays a partially processive 3‘ to 5‘ endonuclease activity
P478volume266

Reverse relations

cites work (P2860)
Q33748246A sequence-dependent exonuclease activity from Tetrahymena thermophila
Q40350043Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptase
Q40410001Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase
Q33947122Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching
Q33815447Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific site
Q39253058HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently
Q24816355HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors
Q45790185Human immunodeficiency virus nucleocapsid protein stimulates strand transfer from internal regions of heteropolymeric RNA templates
Q37296280Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities
Q38333617Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition
Q36804480In vitro synthesis of long DNA products in reactions with HIV-RT and nucleocapsid protein
Q33867556Mechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genome
Q34254673Novel aptamer inhibitors of human immunodeficiency virus reverse transcriptase
Q40401252Quantitative analysis of RNA cleavage during RNAdirected DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases
Q24643032RNase H activity: structure, specificity, and function in reverse transcription
Q34595077Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptases
Q33784655Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis
Q40060658Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase
Q24655903Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription
Q91587761Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase
Q27684014Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage
Q40396110The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybrids
Q38364029The role of template-primer in protection of reverse transcriptase from thermal inactivation
Q36846586Tighter binding of HIV reverse transcriptase to RNA-DNA versus DNA-DNA results mostly from interactions in the polymerase domain and requires just a small stretch of RNA-DNA.
Q36328885Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template
Q35360809Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H

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