Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection

scientific article published on 2 May 2006

Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMTHE.2006.02.016
P698PubMed publication ID16647882
P5875ResearchGate publication ID7133196

P50authorDaniel G. MillerQ42094335
P2093author name stringGeorge Stamatoyannopoulos
David W Emery
Julie Tubb
Mari Aker
P2860cites workDistinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cellsQ24796392
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferencesQ24798872
Matrix attachment regions as targets for retroviral integrationQ24811093
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
High-resolution genome-wide mapping of transposon integration in mammalsQ28769896
Transcription start regions in the human genome are favored targets for MLV integrationQ29618456
HIV-1 integration in the human genome favors active genes and local hotspotsQ29618457
Weak palindromic consensus sequences are a common feature found at the integration target sites of many retrovirusesQ33724262
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liverQ33737640
Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sitesQ33771092
The ups and downs of gene expression and retroviral DNA integrationQ33820016
Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cellsQ34319610
Foamy virus vector integration sites in normal human cellsQ34334976
Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibersQ34344656
Transcriptional Interference by Independently Regulated Genes Occurs in Any Relative Arrangement of the Genes and Is Influenced by Chromosomal Integration PositionQ34440230
RTCGD: retroviral tagged cancer gene databaseQ34923778
American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cellsQ35195407
A chromatin insulator protects retrovirus vectors from chromosomal position effectsQ35198059
Targeting survival: integration site selection by retroviruses and LTR-retrotransposonsQ35563809
Chance or necessity? Insertional mutagenesis in gene therapy and its consequencesQ35637501
Protection and selection for gene therapy in the hematopoietic systemQ35673396
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cellsQ35848227
Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable.Q35929299
Goodness-of-fit tests for discrete data: a review and an application to a health impairment scaleQ36776980
A safe packaging line for gene transfer: separating viral genes on two different plasmidsQ36865708
Genome-wide analyses of avian sarcoma virus integration sitesQ37583468
Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulatorQ40670749
A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cellsQ41066600
Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription.Q42755157
Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectorsQ43980881
Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier statesQ45478033
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cellsQ45856240
Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in intronsQ45879077
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.Q54662841
Evidence for nucleosome depletion at active regulatory regions genome-wideQ54998820
New genes involved in cancer identified by retroviral taggingQ74624557
Murine leukemia induced by retroviral gene markingQ77975543
P433issue2
P921main subjectbiasQ742736
P304page(s)226-235
P577publication date2006-05-02
P1433published inMolecular TherapyQ15762400
P1476titleIntegration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection
P478volume14

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cites work (P2860)
Q38707236Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
Q35751562Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites
Q37795125Gene therapy for β-thalassaemia: the continuing challenge
Q33713390Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
Q33325922HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP
Q35260206Retroviral integration site selection.
Q38913136Significant differences in integration sites of Moloney murine leukemia virus/Moloney murine sarcoma virus retroviral vector carrying recombinant coagulation factor IX in two human cell lines
Q37830029The Use of Chromatin Insulators to Improve the Expression and Safety of Integrating Gene Transfer Vectors
Q39509837The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure.

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