CCN3 regulates proliferation and migration properties in Jeg3 trophoblast cells via ERK1/2, Akt and Notch signalling

scientific article

CCN3 regulates proliferation and migration properties in Jeg3 trophoblast cells via ERK1/2, Akt and Notch signalling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/MOLEHR/GAS061
P698PubMed publication ID23220688
P5875ResearchGate publication ID273624489

P2093author name stringWei Yang
Elke Winterhager
Alexandra Gellhaus
Jessica Wagener
Kathrin Kazuschke
P2860cites workConnexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cellsQ24295100
CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migrationQ24298699
The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathwayQ24298994
CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein FamilyQ24299868
Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healingQ24324036
Functions and mechanisms of action of CCN matricellular proteinsQ24642303
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targetsQ28254386
Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitroQ28343517
NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issuesQ28363601
Posttranscriptional regulation of p53 and its targets by RNA-binding proteinsQ28387511
Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblastsQ33893072
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cellsQ33945648
Critical growth factors and signalling pathways controlling human trophoblast invasionQ34280644
Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signalingQ34280674
A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsiaQ35057672
IFPA Award in Placentology lecture: molecular regulation of human trophoblast invasion.Q35737097
CCN proteins and cancer: two to tangoQ36071619
Signalling pathways regulating the invasive differentiation of human trophoblasts: a reviewQ36100920
92-kD type IV collagenase mediates invasion of human cytotrophoblastsQ36529534
Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblastsQ36636006
The long-term effects of prenatal development on growth and metabolismQ36936030
Preeclampsia: the role of angiogenic factors in its pathogenesisQ37512886
Models for study of human embryo implantation: choice of cell lines?Q37538164
Notch Targets and Their RegulationQ37785199
Impact of CCN3 (NOV) glycosylation on migration/invasion properties and cell growth of the choriocarcinoma cell line Jeg3.Q39501756
CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathwayQ39587555
Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathwaysQ39621889
Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblastQ39726511
Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cellsQ39784719
Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1.Q40013062
EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways.Q40521545
Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migrationQ40538973
Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthaseQ40702575
Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK.Q40786394
Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathwayQ40800243
Expression of integrin alpha 6 beta 4 in human trophoblast and its loss from extravillous cellsQ41572024
Intrauterine programming of adult diseaseQ41671701
CCN3: a key growth regulator in Chronic Myeloid LeukaemiaQ42016116
Trophoblast differentiation during formation of anchoring villi in a model of the early human placenta in vitro.Q42484777
Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat PregnancyQ56981688
Maternal and Social Origins of HypertensionQ57403025
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)237-249
P577publication date2012-12-06
P1433published inMolecular Human ReproductionQ15761794
P1476titleCCN3 regulates proliferation and migration properties in Jeg3 trophoblast cells via ERK1/2, Akt and Notch signalling
P478volume19

Reverse relations

cites work (P2860)
Q37329443Aortic aneurysm, CCN3 may solve the problem
Q37321763CCN family of proteins: critical modulators of the tumor cell microenvironment.
Q36857985CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties
Q34208646Cross-talk between cAMP and MAPK pathways in HSD11B2 induction by hCG in placental trophoblasts
Q36274998Effects of Notch2 and Notch3 on Cell Proliferation and Apoptosis of Trophoblast Cell Lines
Q35821195Epidermal growth factor-like domain 7 promotes migration and invasion of human trophoblast cells through activation of MAPK, PI3K and NOTCH signaling pathways
Q47672242Expression of IGFBP6, IGFBP7, NOV, CYR61, WISP1 and WISP2 genes in U87 glioma cells in glutamine deprivation condition
Q91928851Function of p21 (Cip1/Waf1/CDKN1A) in Migration and Invasion of Cancer and Trophoblastic Cells
Q38937915Notch: A multi-functional integrating system of microenvironmental signals
Q34506462Protein profiling of preeclampsia placental tissues
Q38180619The role of the CCN family of proteins in female reproduction
Q59811736Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways

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