Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality

scientific article

Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1136/JNNP-2012-302674
P698PubMed publication ID23085933

P50authorCatherine LynchQ58028141
Susan ByrneQ61827445
Arun L W BokdeQ78619693
Peter BedeQ87738140
Marwa ElaminQ114339892
Norah JordanQ114339900
Orla HardimanQ30423350
Russell McLaughlinQ37829009
Harald HampelQ38328382
Andrew J. FaganQ42553744
Niall P. PenderQ43564435
P2093author name stringLaura Gallagher
P2860cites workThe ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III).Q53535985
Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS.Q55041563
Amyotrophic lateral sclerosisQ55877676
Sensorimotor Functional Connectivity Changes in Amyotrophic Lateral SclerosisQ57911767
Excellent inter‐rater, intra‐rater, and telephone‐administered reliability of the ALSFRS‐R in a multicenter clinical trialQ58287999
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALSQ24633692
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTDQ24634583
Voxel-based morphometry–the methodsQ28138780
Nonparametric permutation tests for functional neuroimaging: a primer with examplesQ28211607
SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATIONQ29029673
Advances in functional and structural MR image analysis and implementation as FSLQ29547164
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interestQ29615076
El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosisQ29619074
Establishing subtypes of the continuum of frontal lobe impairment in amyotrophic lateral sclerosisQ31105297
Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral SclerosisQ33241059
Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity studyQ33741815
Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosisQ34281282
Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS familyQ34472281
Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALS.Q35098534
Pattern of spread and prognosis in lower limb-onset ALS.Q35239043
Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS.Q35240090
Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72Q35752001
Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort studyQ35859698
Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disabilityQ36227112
Impaired action knowledge in amyotrophic lateral sclerosisQ37179006
ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degenerationQ37593829
Neurodevelopmental and neurodegenerative diseases - is there a pathophysiological link? Attention-deficit/hyperactivity disorder and amyotrophic lateral sclerosis as examplesQ40140962
Global brain atrophy and corticospinal tract alterations in ALS, as investigated by voxel-based morphometry of 3-D MRI.Q40368684
Detection of motor cortex thinning and corticospinal tract involvement by quantitative MRI in amyotrophic lateral sclerosisQ43511549
Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS.Q43797795
The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based studyQ44591084
Structural MRI reveals cortical thinning in amyotrophic lateral sclerosisQ45341661
Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging studyQ46092568
A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD.Q46242205
Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.Q46447991
The diagnostic pathway and prognosis in bulbar-onset amyotrophic lateral sclerosisQ48207344
Voxel-based morphometry study of brain volumetry and diffusivity in amyotrophic lateral sclerosis patients with mild disability.Q48235979
Cognitive functions and white matter tract damage in amyotrophic lateral sclerosis: a diffusion tensor tractography studyQ48827615
Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET studyQ48839997
Frontotemporal white matter changes in amyotrophic lateral sclerosisQ48987798
Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia.Q51014067
Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004.Q51103719
Progression in ALS is not linear but is curvilinear.Q51691332
Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis.Q51868850
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectamyotrophic lateral sclerosisQ206901
neuroimagingQ551875
P304page(s)766-773
P577publication date2012-10-20
P1433published inJournal of Neurology, Neurosurgery and PsychiatryQ1599804
P1476titleGrey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality
P478volume84

Reverse relations

cites work (P2860)
Q38793324A Cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: subphenotypes, staging, cognitive predictors, and survival
Q48146205ALFF Value in Right Parahippocampal Gyrus Acts as a Potential Marker Monitoring Amyotrophic Lateral Sclerosis Progression: a Neuropsychological, Voxel-Based Morphometry, and Resting-State Functional MRI Study
Q36479616ALS biomarkers for therapy development: State of the field and future directions
Q90675194Abnormal Functional Connectivity Density in Amyotrophic Lateral Sclerosis
Q90351947Abnormal topological organization of structural covariance networks in amyotrophic lateral sclerosis
Q48765852Additional resources and the default mode network: Evidence of increased connectivity and decreased white matter integrity in amyotrophic lateral sclerosis
Q92378722Applying the D50 disease progression model to gray and white matter pathology in amyotrophic lateral sclerosis
Q39413097Biomarkers in Neurodegenerative Diseases
Q64228443Clinical Measures of Bulbar Dysfunction in ALS
Q59813023Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis
Q36045826Controversies and priorities in amyotrophic lateral sclerosis
Q48605539Cortical thickness in ALS: towards a marker for upper motor neuron involvement
Q35053698Cortical thinning and clinical heterogeneity in amyotrophic lateral sclerosis
Q58111007Corticospinal tract degeneration in ALS unmasked in T1-weighted images using texture analysis
Q36209956Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study
Q55127801Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology.
Q92537437Editorial: Biomarkers and Clinical Indicators in Motor Neuron Disease
Q35221959Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis.
Q89564264Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study
Q44215931Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study
Q40556132Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis.
Q52098090Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis.
Q33564750Groupwise multi-atlas segmentation of the spinal cord's internal structure
Q40198465High-Resolution 7T MR Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis
Q26860864Lessons of ALS imaging: Pitfalls and future directions - A critical review
Q47352723Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration
Q47844673MR Imaging-based Estimation of Upper Motor Neuron Density in Patients with Amyotrophic Lateral Sclerosis: A Feasibility Study
Q92388747MRI cortical feature of bulbar impairment in patients with amyotrophic lateral sclerosis
Q48239799MRI in amyotrophic lateral sclerosis: more than a promise
Q64087673Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions
Q33863021Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment
Q35202637Microstructural changes across different clinical milestones of disease in amyotrophic lateral sclerosis
Q34682155Microstructural white matter changes underlying cognitive and behavioural impairment in ALS--an in vivo study using DTI
Q48103956Morphometric correlates of dysarthric deficit in amyotrophic lateral sclerosis
Q45869420Motoneuron Disease: Clinical
Q37170150Multiparametric MRI study of ALS stratified for the C9orf72 genotype
Q38384260Neuroimaging as a New Diagnostic Modality in Amyotrophic Lateral Sclerosis
Q30873214Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes
Q52093140Neuroimaging patterns along the ALS-FTD spectrum: a multiparametric imaging study.
Q40094411Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis
Q64065356Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention
Q92202377Patterned functional network disruption in amyotrophic lateral sclerosis
Q90294083Precentral degeneration and cerebellar compensation in amyotrophic lateral sclerosis: A multimodal MRI analysis
Q50091767Quantitative susceptibility mapping of the motor cortex: a comparison of susceptibility among patients with amyotrophic lateral sclerosis, cerebrovascular disease, and healthy controls
Q87147138Regional alterations in cortical thickness and white matter integrity in amyotrophic lateral sclerosis
Q91936690Retinal correlates of neurological disorders
Q58125489Revisiting the pathoanatomy of pseudobulbar affect: mechanisms beyond corticobulbar dysfunction
Q48331848Semiautomated Evaluation of the Primary Motor Cortex in Patients with Amyotrophic Lateral Sclerosis at 3T.
Q45911042Sexual dimorphism in ALS: exploring gender-specific neuroimaging signatures.
Q33908623Side of limb-onset predicts laterality of gray matter loss in amyotrophic lateral sclerosis.
Q64119028Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts-Novel Techniques
Q41581020Subtle retinal pathology in amyotrophic lateral sclerosis
Q33568729Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics
Q60634009The Clinical and Radiological Spectrum of Hippocampal Pathology in Amyotrophic Lateral Sclerosis
Q48721254The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration
Q58125306The selective anatomical vulnerability of ALS: ‘disease-defining’ and ‘disease-defying’ brain regions
Q64075393Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS
Q33822826Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns
Q38883070Voxel-Wise Meta-Analysis of Gray Matter Changes in Amyotrophic Lateral Sclerosis
Q34061536Voxel-based MRI intensitometry reveals extent of cerebral white matter pathology in amyotrophic lateral sclerosis
Q27007017What does imaging reveal about the pathology of amyotrophic lateral sclerosis?
Q34044019Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis
Q39032298Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis
Q48600153miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients.