A three-dimensional model of the human facilitative glucose transporter Glut1.

scientific article published on 24 September 2001

A three-dimensional model of the human facilitative glucose transporter Glut1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M107350200
P698PubMed publication ID11571301

P2093author name stringShi G
Fischbarg J
Iserovich P
Flynn DR
Haller JF
Rubashkin A
Zuniga FA
P2860cites workThe Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding siteQ24312077
Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitorsQ24537539
PROCHECK: a program to check the stereochemical quality of protein structuresQ26778411
Visualization of a water-selective pore by electron crystallography in vitreous iceQ27629440
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modelingQ27860614
Stereochemical quality of protein structure coordinatesQ27860874
Cysteine-scanning mutagenesis of transmembrane segment 7 of the GLUT1 glucose transporterQ28140012
Recognition of errors in three-dimensional structures of proteinsQ28249658
Glucose transporters serve as water channelsQ28282002
Sequence and structure of a human glucose transporterQ28305569
GLUT1-deficiency: barbiturates potentiate haploinsufficiency in vitroQ28377420
Proposed structure of putative glucose channel in GLUT1 facilitative glucose transporterQ30424848
Model of the 3-D structure of the GLUT3 glucose transporter and molecular dynamics simulation of glucose transportQ31913246
Investigation of the structure and function of the human erythrocyte glucose transporter by proteolytic dissectionQ33390953
Defective glucose transport across brain tissue barriers: a newly recognized neurological syndromeQ33607763
Structure and function of facilitative sugar transportersQ33712486
Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytesQ33852762
The pore dimensions of gramicidin A.Q34020191
Evidence from oocyte expression that the erythrocyte water channel is distinct from band 3 and the glucose transporterQ34208370
A molecular mechanism for energy coupling in a membrane transport protein, the lactose permease of Escherichia coliQ36150104
Cloning and characterization of a cDNA encoding the rat brain glucose-transporter proteinQ36425439
Cloning of a rabbit brain glucose transporter cDNA and alteration of glucose transporter mRNA during tissue developmentQ36454982
Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerizationQ38292996
Photolabelling of the hexose transporter at external and internal sites: fragmentation patterns and evidence for a conformational changeQ38349559
Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteinsQ40914739
Helix packing in polytopic membrane proteins: the lactose permease of Escherichia coliQ41573456
Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: N-ethylmaleimide-sensitive face of helix II.Q41760332
Role of tryptophan-388 of GLUT1 glucose transporter in glucose-transport activity and photoaffinity-labelling with forskolinQ42161282
Localization of erythrocyte/HepG2-type glucose transporter (GLUT1) in human placental villiQ42460290
The role of cysteine residues in glucose-transporter-GLUT1-mediated transport and transport inhibitionQ42501264
Structural analysis based on state-space modelingQ42842990
Autosomal dominant transmission of GLUT1 deficiencyQ43514926
Substrate-induced conformational change of human erythrocyte glucose transporter: inactivation by alkylating reagentsQ43599329
The differential role of Cys-421 and Cys-429 of the Glut1 glucose transporter in transport inhibition by p-chloromercuribenzenesulfonic acid (pCMBS) or cytochalasin B (CB)Q43866413
Cysteine-scanning mutagenesis of flanking regions at the boundary between external loop I or IV and transmembrane segment II or VII in the GLUT1 glucose transporterQ47732681
Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteinsQ48418596
Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporterQ48886331
Cysteine scanning mutagenesis of helices 2 and 7 in GLUT1 identifies an exofacial cleft in both transmembrane segmentsQ48896979
Transmembrane segment 5 of the Glut1 glucose transporter is an amphipathic helix that forms part of the sugar permeation pathwayQ48921155
Identification of an amino acid residue that lies between the exofacial vestibule and exofacial substrate-binding site of the Glut1 sugar permeation pathwayQ48949041
From triple cysteine mutants to the cysteine‐less glucose transporter GLUT1: a functional analysisQ49043009
Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acidQ49140908
A novel method for predicting transmembrane segments in proteins based on a statistical analysis of the SwissProt database: the PRED-TMR algorithm.Q52212777
Ligand-dependent quenching of tryptophan fluorescence in human erythrocyte hexose transport proteinQ68786248
Looking for probes of gated channels: studies of the inhibition of glucose and choline transport in erythrocytesQ68987612
Differential labeling of the erythrocyte hexose carrier by N-ethylmaleimide: correlation of transport inhibition with reactive carrier sulfhydryl groupsQ69392490
Epitope Mapping by Label-Free Biomolecular Interaction AnalysisQ71544811
A low resolution model for the interaction of G proteins with G protein-coupled receptorsQ73302726
P433issue48
P407language of work or nameEnglishQ1860
P304page(s)44970-44975
P577publication date2001-09-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleA three-dimensional model of the human facilitative glucose transporter Glut1.
P478volume276

Reverse relations

cites work (P2860)
Q34665566A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity
Q41837532An insulin-like modular basis for the evolution of glucose transporters (GLUT) with implications for diabetes
Q43802409Analysis of transmembrane segment 10 of the Glut1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility
Q44007442Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer
Q34991034Expression, regulation, and functional role of glucose transporters (GLUTs) in brain
Q44586487Functional studies of threonine 310 mutations in Glut1: T310I is pathogenic, causing Glut1 deficiency
Q37623840GLUT1 as a therapeutic target in hepatocellular carcinoma
Q35625599Genes and proteins for solute transport and sensing
Q34657833Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors
Q34454035Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7).
Q36127845In silico strategies for modeling membrane transporter function.
Q43002061Interactions of ATP, oestradiol, genistein and the anti-oestrogens, faslodex (ICI 182780) and tamoxifen, with the human erythrocyte glucose transporter, GLUT1.
Q35045733Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1.
Q28476422Molecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibition
Q44013223Mutational analysis of the hexose transporter of Plasmodium falciparum and development of a three-dimensional model
Q41975275Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes.
Q41954486Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport.
Q34187609Predicting the three-dimensional structure of the human facilitative glucose transporter glut1 by a novel evolutionary homology strategy: insights on the molecular mechanism of substrate migration, and binding sites for glucose and inhibitory molecu
Q37447578Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease
Q36711153Structural signatures and membrane helix 4 in GLUT1: inferences from human blood-brain glucose transport mutants
Q28204545The SLC2 family of facilitated hexose and polyol transporters
Q44776061The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway.
Q35029376Towards a new age of virtual ADME/TOX and multidimensional drug discovery
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Q34658418Vitamin C transporters.
Q35537890Why is the Plasmodium falciparum hexose transporter a promising new drug target?

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