Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury

scientific article published in December 2001

Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-8993(01)03148-1
P698PubMed publication ID11730700

P50authorPeter GluckmanQ7174263
P2093author name stringSizonenko SV
Williams CE
Sirimanne ES
P2860cites workInsulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brainQ28564683
Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat.Q30739816
Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in ratsQ33924997
Mechanisms underlying hypoxia-induced neuronal apoptosisQ33935219
The temporal evolution of hypoglycemic brain damage. I. Light- and electron-microscopic findings in the rat cerebral cortexQ34199337
A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injuryQ34247862
Enhanced potency of truncated insulin-like growth factor-I (des(1-3)IGF-I) relative to IGF-I in lit/lit miceQ34288558
Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I actionQ34295738
Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal lossQ34312208
Outcome after ischemia in the developing sheep brain: an electroencephalographic and histological studyQ34352573
The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrationsQ35052930
Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor IQ35615447
Des (1-3) IGF-I potently enhances differentiated cell growth in olfactory bulb organ cultureQ38312984
Ability of retinal Müller glial cells to protect neurons against excitotoxicity in vitro depends upon maturation and neuron-glial interactionsQ39062493
The role of the insulin-like growth factors in the regulation of brain developmentQ39523447
Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambsQ39757754
The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factorsQ40527824
The biological role of truncated insulin-like growth factor-1 and the tripeptide GPE in the central nervous systemQ40768897
A comparison of the biological activity of the recombinant intact and truncated insulin-like growth factor 1 (IGF-1).Q41256225
Identity of neurotrophic molecules released from astroglia by vasoactive intestinal peptideQ41478941
The temporal evolution of hypoglycemic brain damage. II. Light- and electron-microscopic findings in the hippocampal gyrus and subiculum of the rat.Q41501885
Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxideQ41699826
Dose- and time-dependence of L-NAME neuroprotection in transient focal cerebral ischaemia in ratsQ42013111
Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep.Q42483478
Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrestQ42499063
Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.Q43517443
Hypoxia-ischemia in the neonatal rat brain: histopathology after post-treatment with NMDA and non-NMDA receptor antagonistsQ44055116
Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptideQ44399796
Neuroprotective efficacy of N omega-nitro-L-arginine after focal cerebral ischemia in the mouse and inhibition of cortical nitric oxide synthaseQ48124605
Alterations in the neural growth hormone axis following hypoxic-ischemic brain injuryQ48214978
The effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats.Q48239072
Neuroprotective effects of Gly-Pro-Glu, the N-terminal tripeptide of IGF-1, in the hippocampus in vitroQ48254313
The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats.Q48259779
Isolation and characterization of variant IGF-1 as well as IGF-2 from adult human brainQ48342472
The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous systemQ48377406
Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injuryQ48399935
A non-surgical technique for accurate intracerebral injections in ratQ48500346
Hypoxia-ischemia induces transforming growth factor beta 1 mRNA in the infant rat brainQ48524216
Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat.Q48532402
The temporal evolution of hypoglycemic brain damage. III. Light and electron microscopic findings in the rat caudoputamenQ48549496
Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiencyQ48559488
The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusionQ48564690
The effect of prolonged modification of cerebral temperature on outcome after hypoxic-ischemic brain injury in the infant rat.Q49020421
Truncated IGF-1 exerts trophic effects on fetal brain tissue graftsQ49035766
Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus.Q49084529
Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brainQ49129325
Intracerebral transportation and cellular localisation of insulin-like growth factor-1 following central administration to rats with hypoxic-ischemic brain injury.Q52171644
Role of insulin-like growth factor binding proteins in limitation of IGF-I degradation into the N-methyl-D-aspartate receptor antagonist GPE: evidence from gonadotrophin-releasing hormone secretion in vitro at two developmental stages.Q52172974
Two models for determining the mechanisms of damage and repair after hypoxic-ischaemic injury in the developing rat brain.Q52213486
The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteinsQ61865404
The role of inducible transcription factors in apoptotic nerve cell deathQ70864244
Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesisQ71675839
Truncation of IGF-I yields two mitogens for retinal Müller glial cellsQ71798550
Neuroprotective activity of HU-211, a novel NMDA antagonist, in global ischemia in gerbilsQ72124391
Acute suppression of gonadotropin-releasing hormone secretion by insulin-like growth factor I and subproducts: an age-dependent endocrine effectQ72259482
Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brainQ72866466
Generation of des-(1-3) insulin-like growth factor-I in serum by an acid proteaseQ72876621
Effects of somatostatin, octreotide and cortistatin on ischaemic neuronal damage following permanent middle cerebral artery occlusion in the ratQ73320030
Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorylation of the pro-apoptotic protein BAD but not to inhibition of cytochrome c translocation in rat cerebellar neuronsQ73539453
Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelinationQ74046440
Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawalQ77308520
Neuronal death and survival in two models of hypoxic-ischemic brain damageQ77343222
Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucoseQ77395621
Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-betaQ77581125
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)42-50
P577publication date2001-12-01
P1433published inBrain ResearchQ4955782
P1476titleNeuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury
P478volume922

Reverse relations

cites work (P2860)
Q44760148A three amino acid peptide, Gly-Pro-Arg, protects and rescues cell death induced by amyloid beta-peptide
Q30760213Advances in postnatal neuroimaging: relevance to pathogenesis and treatment of brain injury.
Q36427698Combination Therapies for Traumatic Brain Injury: Retrospective Considerations
Q48962363Distinctive neuropathologic alterations in the deep layers of the parietal cortex after moderate ischemic-hypoxic injury in the P3 immature rat brain
Q41555531Effect of transgenic human insulin-like growth factor-1 on spinal motor neurons following peripheral nerve injury
Q48487775Electroacupuncture induced spinal plasticity is linked to multiple gene expressions in dorsal root deafferented rats
Q38722527GPE Promotes the Proliferation and Migration of Mouse Embryonic Neural Stem Cells and Their Progeny In Vitro.
Q37479916IGF-1 derived small neuropeptides and analogues: a novel strategy for the development of pharmaceuticals for neurological conditions
Q37705471Inflammatory injury to the neonatal brain - what can we do?
Q82623154Insulin-Like Growth Factor-1 Regulates Neurite Outgrowth and Neuronal Migration From Organotypic Cultured Dorsal Root Ganglion
Q35690505Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide
Q37441140Lignocaine: neuro-protective or wishful thinking?
Q42499967Molecular mechanism underlying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model
Q24651541Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
Q88783440Perturbation Theory/Machine Learning Model of ChEMBL Data for Dopamine Targets: Docking, Synthesis, and Assay of New l-Prolyl-l-leucyl-glycinamide Peptidomimetics
Q38346186Potential role of IGF-I in hypoxia tolerance using a rat hypoxic-ischemic model: activation of hypoxia-inducible factor 1alpha
Q34063244The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist
Q60045414The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging
Q38344573The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders

Search more.