Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time

scientific article published in December 2001

Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0014-2999(01)01432-7
P698PubMed publication ID11755147

P2093author name stringYamamoto H
Hirose K
Kihara H
Yoshimoto R
Koganei H
P2860cites workSerotonin release into plasma during common carotid artery thrombosis in ratsQ33216922
Serotonergic Receptor Subtypes and Vascular ReactivityQ40112563
Retrospective analyses for hypothesis generation. A commentary on the PACK trial (prevention of atherosclerotic complications with ketanserin).Q41297627
Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022.Q42548747
Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteriesQ42651476
Local effect of serotonin released during coronary angioplastyQ72088366
Inhibition of 5-hydroxytryptamine-induced and-amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonistQ72768706
AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral vascular lesion in ratsQ73697435
The PACK trial: morbidity and mortality effects of ketanserin. Prevention of Atherosclerotic ComplicationsQ74453608
5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets functionQ77425309
Serotonin is associated with coronary artery disease and cardiac eventsQ78077693
P433issue2-3
P407language of work or nameEnglishQ1860
P921main subjectthrombosisQ261327
P304page(s)157-162
P577publication date2001-12-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleAntithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time
P478volume433

Reverse relations

cites work (P2860)
Q27348866A Novel Model of Intravital Platelet Imaging Using CD41-ZsGreen1 Transgenic Rats
Q44114280AT-1015, a newly synthesized 5-HT2 receptor antagonist, dissociates slowly from the 5-HT2 receptor sites in rabbit cerebral cortex membrane
Q34953029Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration
Q33435199Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo
Q38799483Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice
Q80490295Hemostatic properties of a venomic protein in rodent dermal injuries
Q46892256Inhibition of 5-hydroxytryptamine receptor prevents occlusive thrombus formation on neointima of the rabbit femoral artery
Q42166606Insurmountable antagonism of AT-1015, a 5-HT2 antagonist, on serotonin-induced endothelium-dependent relaxation in porcine coronary artery
Q47393214Lung Endothelium Targeting for Pulmonary Embolism Thrombolysis
Q44961036Randomized trial of AT-1015 for treatment of intermittent claudication. A novel 5-hydroxytryptamine antagonist with no evidence of efficacy
Q35814472Sarpogrelate: cardiovascular and renal clinical potential
Q35117079The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation

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