Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis

scientific article published in January 2002

Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1053190579
P356DOI10.1038/SJ.ONC.1205066
P698PubMed publication ID11821945
P5875ResearchGate publication ID11538087

P50authorMien-Chie HungQ1532952
P2093author name stringBrian Varnum
Yong Wen
Wei-Ping Lee
P2860cites workAkt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseQ24310364
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascadeQ24310383
Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6Q24313270
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Phosphorylation and regulation of Raf by Akt (protein kinase B)Q28138863
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinaseQ28144326
NF-kappaB is a target of AKT in anti-apoptotic PDGF signallingQ28144330
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase BbetaQ28255046
Interleukin-3-induced phosphorylation of BAD through the protein kinase AktQ28255373
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenesQ28265486
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulationQ28589590
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseQ29618387
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionQ29618388
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene productsQ33630332
Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activityQ33960576
Tumor suppression activity of adenovirus E1a protein: anoikis and the epithelial phenotypeQ34061955
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesQ34319294
The receptor tyrosine kinase ARK mediates cell aggregation by homophilic bindingQ36566375
Differential requirement for adenovirus type 12 E1A gene products in oncogenic transformation.Q36784172
Transformation of NIH 3T3 cells by cotransfection with c-src and nuclear oncogenesQ36922532
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogeneQ36961265
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteinsQ37162513
Antioncogenic effect of adenovirus E1A in human tumor cellsQ37605329
Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblastsQ40022933
Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trialQ40599715
Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptorQ41067751
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.Q41563742
HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathwayQ42804558
Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras.Q42812461
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in cultureQ43891070
Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.Q52532536
E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activitiesQ64381387
The erbB2 gene as a cancer therapeutic target and the tumor- and metastasis-suppressing function of E1AQ64381899
GAS6 induces Axl-mediated chemotaxis of vascular smooth muscle cellsQ74326161
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)329-336
P577publication date2002-01-01
P1433published inOncogeneQ1568657
P1476titleAkt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis
P478volume21

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cites work (P2860)
Q37665524A novel application of E1A in combination therapy with EGFR-TKI treatment in breast cancer
Q42359111AXL-GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases
Q38742188Anexelekto (AXL) Increases Resistance to EGFR-TKI and Activation of AKT and ERK1/2 in Non-Small Cell Lung Cancer Cells
Q39490176Axl is a prognostic marker in oral squamous cell carcinoma
Q39633320Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members.
Q33916284Blockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer
Q42693450Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling
Q64258088Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl
Q34564800Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule
Q51672088Effects of extracellular acid stimulation on rat vascular smooth muscle cell in Gas6/Axl or PI3K/Akt signaling pathway.
Q37118186Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines
Q36546044Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity.
Q49636410Function of Axl receptor tyrosine kinase in non-small cell lung cancer
Q90119561Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway
Q38763966Gene of the month: Axl.
Q38003815Growth arrest-specific gene 6 (gas6) and vascular hemostasis
Q33265521Heterogeneity of mammary lesions represent molecular differences
Q35125173Inactivation of GSK3β and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma.
Q45866974Insertional mutagenesis by replication-deficient retroviral vectors encoding the large T oncogene
Q64378213Involvement of Bcl-X(L) deamidation in E1A-mediated cisplatin sensitization of ovarian cancer cells
Q39157476Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies
Q36461930Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells
Q92717407Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer
Q91292042PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis
Q55345918Potential Molecular Signatures Predictive of Lung Cancer Brain Metastasis.
Q34451033Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase
Q24540107RETRACTED: A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control
Q39592978Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer
Q35923996Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis
Q38720434Role of AXL expression in non-small cell lung cancer
Q34794927TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer
Q34545399TWIST1 drives cisplatin resistance and cell survival in an ovarian cancer model, via upregulation of GAS6, L1CAM, and Akt signalling
Q35927501Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors
Q35832938Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer
Q34515144The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma
Q28068756The Receptor Tyrosine Kinase AXL in Cancer Progression
Q54298179The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.
Q38185905The anti-tumor activity of E1A and its implications in cancer therapy
Q39381139The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.
Q61810968Transcatheter arterial embolization combined with hypoxia-replicative oncolytic adenovirus perfusion enhances the therapeutic effect of hepatic carcinoma
Q28509359Twist mediates suppression of inflammation by type I IFNs and Axl
Q24295256Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
Q37122103Vitamin K-dependent actions of Gas6.

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