Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: evaluation of the protective role of the metabolic modulator trimetazidine

scientific article published in February 2002

Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: evaluation of the protective role of the metabolic modulator trimetazidine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0735-1097(01)01768-5
P698PubMed publication ID11823078
P5875ResearchGate publication ID11537298

P2093author name stringAlberto Margonato
Gabriele Fragasso
Emanuela Setola
Lucilla Monti
Pier Marco Piatti
Giliola Calori
Altin Palloshi
Sergio Chierchia
Gianpietro Valsecchi
Guido Pozza
Chunzeng Lu
P2860cites workThe antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolaseQ28373346
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Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenationQ34059096
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Elevated circulating free fatty acid levels impair endothelium-dependent vasodilationQ37372004
Alterations of carbohydrate and lipid metabolism in the acutely ischemic heartQ40304120
Effects of glucose and fatty acids on myocardial ischaemia and arrhythmiasQ40619598
Metabolic management of ischaemic heart diseaseQ40619954
Regulation of fatty acid oxidation in the mammalian heart in health and diseaseQ40682538
Effects of trimetazidine on pHi regulation in the rat isolated ventricular myocyteQ41932287
Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study GroupQ42138849
Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery diseaseQ42538885
Fluorimetric methods for the measurement of intermediate metabolites (lactate, pyruvate, alanine, beta-hydroxybutyrate, glycerol) using a COBAS FARA centrifugal analyserQ42785432
Effects of propranolol on the hemodynamic, coronary sinus blood flow and myocardial metabolic response to atrial pacingQ44764738
Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragmentQ47194896
Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitorQ47295608
Plasma lipolytic activity and substrate oxidation after intravenous administration of heparin and a low molecular weight heparin fragmentQ47440477
Metabolism of exogenous substrates by coronary endothelial cells in culture.Q50876916
Effects of low-dose heparin infusion on arterial endothelin-1 release in humans.Q51578477
Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans.Q51582709
Effects of ranolazine on ischemic threshold, coronary sinus blood flow, and myocardial metabolism in coronary artery diseaseQ60302420
Internal pH, Na+, and Ca2+ regulation by trimetazidine during cardiac cell acidosisQ67269624
Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swineQ67376789
The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemiaQ67983961
Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemiaQ68697945
Acute effects of trimetazidine evaluated by exercise testingQ69468162
Immunoreactive endothelin in human plasma: marked elevations in patients in cardiogenic shockQ69509803
Comparison of trimetazidine with nifedipine in effort angina: a double-blind, crossover studyQ70284229
Effects of trimetazidine on ischemic contracture in isolated perfused rat heartsQ71644831
Beta adrenergic blockade. Hemodynamics and myocardial energy metabolism in patients with ischemic heart diseaseQ72107816
Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemiaQ72187801
Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitriteQ72199386
High-dose heparin decreases nitric oxide production by cultured bovine endothelial cellsQ73303028
Endothelin release: a marker for the severity of exercise-induced ischemiaQ73999661
Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomographyQ77298829
High-dose heparin impairs nitric oxide pathway and vasomotion in ratsQ77846334
Effects of trimetazidine on metabolic and functional recovery of postischemic rat heartsQ78014325
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P433issue3
P407language of work or nameEnglishQ1860
P921main subjectheparinQ190016
coronary artery diseaseQ844935
P304page(s)413-419
P577publication date2002-02-01
P1433published inJournal of the American College of CardiologyQ2984355
P1476titleAcute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: evaluation of the protective role of the metabolic modulator trimetazidine
P478volume39

Reverse relations

cites work (P2860)
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Q88711636Deranged Cardiac Metabolism and the Pathogenesis of Heart Failure
Q44470060Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart
Q40527264Impact of low-flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart
Q46417512Influence of insulin and free fatty acids on contractile function in patients with chronically stunned and hibernating myocardium
Q36355273Metabolic modulators for chronic cardiac ischemia
Q44886445Myocardial insulin resistance associated with chronic hypertriglyceridemia and increased FFA levels in Type 2 diabetic patients.
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Q44642224Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy
Q37165686Trimetazidine revisited: a comprehensive review of the pharmacological effects and analytical techniques for the determination of trimetazidine