Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.

scientific article published in February 2002

Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons. is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.22-03-00666.2002
P932PMC publication ID6758493
P698PubMed publication ID11826096

P50authorStefan OffermannsQ2337253
P2093author name stringMichael Krause
Martin Stocker
Paola Pedarzani
P2860cites workG(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 regionQ28505361
Muscarinic inhibition of calcium current and M current in Galpha q-deficient miceQ28505490
Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking GalphaqQ28506811
Properties and ionic mechanisms of a metabotropic glutamate receptor-mediated slow afterdepolarization in neocortical neuronsQ71660376
Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampusQ72334900
Glutamate metabotropic receptors increase a Ca(2+)-activated nonspecific cationic current in CA1 hippocampal neuronsQ72413276
PKA mediates the effects of monoamine transmitters on the K+ current underlying the slow spike frequency adaptation in hippocampal neuronsQ72689526
G-protein-independent signaling mediated by metabotropic glutamate receptorsQ73202431
Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptorsQ73374924
Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o)Q73434917
A protein phosphatase is involved in the cholinergic suppression of the Ca(2+)-activated K(+) current sI(AHP) in hippocampal pyramidal neuronsQ73665675
The alpha subunit of Gq contributes to muscarinic inhibition of the M-type potassium current in sympathetic neuronsQ28576003
Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant miceQ28589329
Receptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messengerQ30307134
Acetylcholine in mind: a neurotransmitter correlate of consciousness?Q33650561
New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies.Q33720886
Convergence and divergence of neurotransmitter action in human cerebral cortexQ34313988
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in miceQ34446698
An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neuronsQ35136462
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptorsQ36921192
The coupling of neurotransmitter receptors to ion channels in the brainQ38190800
Gq protein alpha subunits Galphaq and Galpha11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cellsQ38313363
Modulation of ion-channel function by G-protein-coupled receptorsQ40397855
Get receptive to metabotropic glutamate receptorsQ40425888
Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteinsQ41048227
Activation of the pharmacologically defined M3 muscarinic receptor depolarizes hippocampal pyramidal cellsQ41190298
Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitabilityQ41333436
Muscarinic receptors involved in hippocampal plasticityQ41447553
Muscarinic mechanisms in nerve cellsQ41447596
Reduction of resting K+ current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-proteinsQ41501218
Heterologous Expression of Receptors and Signaling Proteins in Adult Mammalian Sympathetic Neurons by MicroinjectionQ41520175
Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq familyQ41589058
Modulation of a slowly inactivating potassium current, I(D), by metabotropic glutamate receptor activation in cultured hippocampal pyramidal neurons.Q41683700
Gq and G11 are concurrently activated by bombesin and vasopressin in Swiss 3T3 cellsQ42834874
Voltage clamp analysis of cholinergic action in the hippocampusQ44275193
Specific involvement of Ca(2+)-calmodulin kinase II in cholinergic modulation of neuronal responsivenessQ46492334
Cholinergic excitation of mammalian hippocampal pyramidal cellsQ46556953
Voltage-clamp analysis of muscarinic excitation in hippocampal neuronsQ46810873
Muscarinic receptors regulate two different calcium-dependent non-selective cation currents in rat prefrontal cortexQ48204967
Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicityQ48283480
Immunohistochemical distribution of neurons containing the G-proteins Gq alpha/G11 alpha in the adult rat brainQ48411417
Muscarinic potentiation of IK in hippocampal neurons: electrophysiological characterization of the signal transduction pathwayQ48413439
Reduction of Potassium Conductances Mediated by Metabotropic Glutamate Receptors in Rat CA3 Pyramidal Cells Does Not Require Protein Kinase C or Protein Kinase A.Q48552017
Calcium-activated cation nonselective current contributes to the fast afterdepolarization in rat prefrontal cortex neuronsQ48614591
The pharmacology of cholinergic excitatory responses in hippocampal pyramidal cellsQ48646201
Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cellsQ48737526
Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmittersQ48876688
Tyrosine kinase inhibitors enhance a Ca(2+)-activated K+ current (IAHP) and reduce IAHP suppression by a metabotropic glutamate receptor agonist in rat dentate granule neurones.Q48902544
Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neuronsQ48904787
Evidence that Ca/calmodulin-dependent protein kinase mediates the modulation of the Ca2+-dependent K+ current, IAHP, by acetylcholine, but not by glutamate, in hippocampal neuronsQ49108366
Function of metabotropic glutamate receptors in learning and memory.Q52047835
Use of antisense expression plasmids to attenuate G-protein expression in primary neurons.Q52864899
Injection of antisera into cells to study G-protein regulation of channel function.Q55482485
Classification of muscarinic responses in hippocampus in terms of receptor subtypes and second-messenger systems: electrophysiological studies in vitroQ58409840
Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neuroneQ59066538
Carbachol Potentiates Q Current and Activates a Calcium-dependent Non-specific Conductance in Rat HippocampusIn VitroQ60507013
Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteinsQ68240329
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortexQ69419174
Regional distribution and quantitative measurement of the phosphoinositidase C-linked guanine nucleotide binding proteins G11 alpha and Gq alpha in rat brainQ70472264
Dopamine modulates the slow Ca(2+)-activated K+ current IAHP via cyclic AMP-dependent protein kinase in hippocampal neuronsQ71365406
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)666-673
P577publication date2002-02-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleFunctional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons
P478volume22