Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain

scientific article published in October 2013

Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1590/1516-4446-2012-0886
P698PubMed publication ID24402213
P5875ResearchGate publication ID259630082

P50authorAntonio Waldo ZuardiQ60324489
José A CrippaQ64857123
Jaime Eduardo Cecilio HallakQ89090861
Roger B VarelaQ98181239
Daniela V BavarescoQ98937455
João QuevedoQ42644849
Giselli ScainiQ42968861
Emilio L StreckQ42968871
P2093author name stringSamira S Valvassori
Marcos H Chagas
P2860cites workThe GRACILE syndrome, a neonatal lethal metabolic disorder with iron overloadQ43672303
Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopyQ43737909
Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cellsQ44804966
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's diseaseQ46443478
Brain creatine kinase activity in an animal model of maniaQ46811362
Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activityQ46977833
Immunoelectron microscopic investigation of creatine kinase BB-isoenzyme after cerebral ischemia in gerbilsQ48376156
Abnormal properties of creatine kinase in Alzheimer's disease brain: correlation of reduced enzyme activity and active site photolabeling with aberrant cytosol-membrane partitioningQ48471962
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.Q55032889
Pharmacological and therapeutic targets for ?9 tetrahydrocannabinol and cannabidiolQ55931493
GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1LQ24617140
Effects of creatine on mental fatigue and cerebral hemoglobin oxygenationQ28216292
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Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain traumaQ31149457
N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunctionQ31997000
Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytesQ33652502
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drugQ33995048
Cannabidiol--recent advancesQ34005880
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Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjectsQ34253509
Neural mechanisms for the cannabinoid modulation of cognition and affect in man: a critical review of neuroimaging studiesQ34310759
Functional aspects of creatine kinase in brain.Q34314804
Mitochondria and degenerative disordersQ34386737
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
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Mitochondrial permeability transition in CNS trauma: cause or effect of neuronal cell death?Q35968596
Functions and effects of creatine in the central nervous system.Q37172733
Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of actionQ37285921
Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subjectQ37594110
Mitochondria as sensors and regulators of calcium signallingQ38031124
Respiratory chain complex II as general sensor for apoptosisQ38045648
Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brainQ38561941
Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.Q39881941
Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell deathQ40069054
Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvementQ40313822
Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energeticsQ40676646
Mitochondrial heterogeneity in the brain at the cellular levelQ41719646
Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of maniaQ43235417
P433issue4
P921main subjectcannabidiolQ422917
cannabinoidsQ422936
P304page(s)380-386
P577publication date2013-10-01
P1433published inBrazilian Journal of PsychiatryQ7318477
P1476titleAcute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain
P478volume35

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cites work (P2860)
Q38598487An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
Q97428443Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research
Q55387906Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
Q37595135Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons
Q38828985Evidences for the Anti-panic Actions of Cannabidiol
Q36157649Molecular Targets of Cannabidiol in Neurological Disorders
Q60047511Morphine Binds Creatine Kinase B and Inhibits Its Activity
Q48596972The adenosine salvage pathway as an alternative to mitochondrial production of ATP in maturing mammalian oocytes
Q57300019Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

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