Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord.

scientific article published in February 2002

Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.22-04-01228.2002
P932PMC publication ID6757570
P698PubMed publication ID11850450

P2093author name stringMegumu Yoshimura
Hidemasa Furue
Jianguo G Gu
Terumasa Nakatsuka
P2860cites workThe capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesiaQ28144926
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunitsQ28199881
Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channelsQ28288639
A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of painQ28333413
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)Q28343961
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substancesQ28344313
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamideQ28370516
Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptorsQ28507876
Impaired nociception and pain sensation in mice lacking the capsaicin receptorQ28511370
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient miceQ28588984
Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic gangliaQ77684346
ATP P2x receptors and sensory synaptic transmission between primary afferent fibers and spinal dorsal horn neurons in ratsQ77716721
The cloned capsaicin receptor integrates multiple pain-producing stimuliQ29547511
Capsaicin, protons and heat: new excitement about nociceptors.Q33594435
Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. II. Genetic approaches to pain therapyQ33890483
Pharmacology of cloned P2X receptorsQ33932194
Physiological properties of unmyelinated fiber projection to the spinal cordQ34242016
Cell type-specific ATP-activated responses in rat dorsal root ganglion neuronsQ35028434
Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neuronsQ37182629
Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistryQ37460532
Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sitesQ38326421
Actions of capsaicin on mouse dorsal root ganglion cells in vitroQ39403741
Effect of preemptive nerve block on inflammation and hyperalgesia after human thermal injuryQ39465885
Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.Q41080089
Purinergic receptors: their role in nociception and primary afferent neurotransmissionQ41103378
Distinct ATP receptors on pain-sensing and stretch-sensing neurons.Q41109141
P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee jointQ42182102
Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors.Q43638937
ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord.Q43715917
Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cordQ44134973
The effects of electrical stimulation of A and C visceral afferent fibres on the excitability of viscerosomatic neurones in the thoracic spinal cord of the cat.Q44479153
Neurogenic hyperalgesia: psychophysical studies of underlying mechanismsQ45020805
Action of capsaicin on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slicesQ48188347
Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cordQ48297298
Responses of dorsal horn cells of M. mulatta to cutaneous and sural nerve A and C fiber stimuliQ48968795
Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons.Q50513708
Alteration in synaptic inputs through C-afferent fibers to substantia gelatinosa neurons of the rat spinal dorsal horn during postnatal development.Q52164424
Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury.Q53803625
Adenosine triphosphate-evoked currents in cultured dorsal root ganglion neurons obtained from rat embryos: desensitization kinetics and modulation of glutamate release.Q54027022
Morphological features of lamina V neurons receiving nociceptive input in cat sacrocaudal spinal cord.Q54185173
ATP excites a subpopulation of rat dorsal horn neuronesQ59077612
Pharmacologically induced selective degeneration of chemosensitive primary sensory neuronesQ59082877
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapsesQ59087865
Receptor for ATP in the membrane of mammalian sensory neuronesQ67288475
Morphology and ultrastructure of physiologically identified substantia gelatinosa (lamina II) neurons with axons that terminate in deeper dorsal horn laminae (III-V)Q68268728
Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicinQ69609149
Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicinQ69728724
Two group of spinal interneurones that respond to stimulation of the abdominal viscera of the catQ70314576
Convergence of cardiac and cutaneous afferents onto neurons in the dorsal horn of the spinal cord in the catQ71079895
Synaptic strengthening through activation of Ca2+-permeable AMPA receptorsQ71133430
Distribution patterns of different P2x receptor phenotypes in acutely dissociated dorsal root ganglion neurons of adult ratsQ73065417
Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptorQ73579417
ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapsesQ73680790
Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neuronsQ74014541
Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglionQ77370861
P2X3 is expressed by DRG neurons that terminate in inner lamina IIQ77586614
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1228-1237
P577publication date2002-02-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleActivation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord
P478volume22

Reverse relations

cites work (P2860)
Q36574960A combined electrophysiological and morphological study of neuropeptide Y-expressing inhibitory interneurons in the spinal dorsal horn of the mouse
Q36173752ATP receptors in pain sensation: Involvement of spinal microglia and P2X(4) receptors
Q35216840Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception
Q50698300Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.
Q46612877Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin
Q47644557Angiotensin type 1 receptor immunoreactivity in the thoracic spinal cord
Q44121194Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro
Q41830053Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging
Q52020785Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors.
Q44318938Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat.
Q55036805Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons.
Q26765229Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation
Q33898994Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.
Q60053955Ethanol-induced enhancement of inhibitory synaptic transmission in the rat spinal substantia gelatinosa
Q40353643In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn.
Q44451101Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli
Q44383098Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat.
Q35774516Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons.
Q28571331Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons
Q37116100Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C.
Q35568673P2X Receptor-Mediated Modulation of Sensory Transmission to the Spinal Cord Dorsal Horn
Q36425578P2X purinoceptors and sensory transmission
Q37135470P2X receptor-mediated purinergic sensory pathways to the spinal cord dorsal horn
Q36977790P2X3 receptor involvement in pain states
Q35165495P2X3 receptors and peripheral pain mechanisms
Q40364423Postnatal Excitability Development and Innervation by Functional Transient Receptor Potential Vanilloid 1 (TRPV1) Terminals in Neurons of the Rat Spinal Sacral Dorsal Commissural Nucleus: an Electrophysiological Study
Q79960832Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse
Q44418969Presynaptic Facilitation of Glutamatergic Synapses to Dopaminergic Neurons of the Rat Substantia Nigra by Endogenous Stimulation of Vanilloid Receptors
Q48347143Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by noradrenaline in nociceptive neurons
Q37255327Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones.
Q42003262Purinergic P2X receptors facilitate inhibitory GABAergic and glycinergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.
Q44902312Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius.
Q33503225Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia
Q42435213Simultaneous recordings of wind-up of paired spinal dorsal horn nociceptive neuron and nociceptive flexion reflex in rats
Q33889031Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors
Q34544649Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanisms
Q27021608TRP channels and analgesia
Q37057494TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation
Q38587736TRPs and pain
Q44497343The activation of 5-HT(3) receptors evokes GABA release in the spinal cord
Q34157706The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword
Q38220010Transient receptor potential channels as targets for phytochemicals
Q44132618Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius.