Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism

scientific article published in April 2002

Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0021-9150(01)00674-8
P698PubMed publication ID11888522

P2093author name stringMasafumi Takahashi
Uichi Ikeda
Hitoaki Okazaki
Kazuyuki Shimada
Koichi Takeuchi
Yukiyo Ogata
P2860cites workIdentification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisQ28292299
Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesisQ33567912
Oxidized LDL and expression of monocyte adhesion moleculesQ33788659
Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathwaysQ33870001
Apoptosis in atherosclerosis: beneficial or detrimental?Q33870047
Phospholipase A2 activity of low density lipoprotein: evidence for an intrinsic phospholipase A2 activity of apoprotein B-100.Q33925421
Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cellsQ34128848
TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like proteaseQ34486473
Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cellsQ35822759
7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoproteinQ35916215
The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosisQ36086849
Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinaseQ37361935
Life, death, and the pursuit of apoptosis.Q40942974
The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heatQ41200518
JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cellsQ41202424
Metabolism of lysolecithin in vivo and in vitro with particular emphasis on the arterial wall.Q45249258
Lysolecithin binding to human and squirrel monkey plasma and tissue componentsQ48624793
Suppression of endothelin-1 secretion by lysophosphatidylcholine in oxidized low density lipoprotein in cultured vascular endothelial cells.Q50790309
Endothelial cell apoptosis induced by oxidized LDL is associated with the down-regulation of the cellular caspase inhibitor FLIP.Q54114474
Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteinsQ59060592
Oxidized LDLs Induce Massive Apoptosis of Cultured Human Endothelial Cells Through a Calcium-Dependent PathwayQ59315368
Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis.Q64907197
Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donorsQ71056560
Induction of monocyte chemoattractant protein-1 synthesis in human monocytes during transendothelial migration in vitroQ72187792
Apoptosis in human atherosclerosis and restenosisQ72256402
4-Hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cellsQ72567050
Lysophosphatidylcholine activates mitogen-activated protein kinases by a tyrosine kinase-dependent pathway in bovine aortic endothelial cellsQ77366607
P433issue2
P921main subjectendotheliumQ111140
P304page(s)387-394
P577publication date2002-04-01
P1433published inAtherosclerosisQ4813570
P1476titleLysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism
P478volume161