Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

scientific article published on 27 August 2003

Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M308643200
P698PubMed publication ID12944394

P2093author name stringA S Verkman
Francis C Szoka
N D Sonawane
P433issue45
P407language of work or nameEnglishQ1860
P304page(s)44826-44831
P577publication date2003-08-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleChloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
P478volume278

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cites work (P2860)
Q58610538-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact
Q342087512011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery
Q3985336164Cu-labeled PEGylated polyethylenimine for cell trafficking and tumor imaging
Q40212198A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery
Q33338185A combinatorial polymer library approach yields insight into nonviral gene delivery
Q46028311A comparison of thiolated and disulfide-crosslinked polyethylenimine for nonviral gene delivery.
Q37332356A family of bioreducible poly(disulfide amine)s for gene delivery
Q37031613A highly efficient synthetic vector: nonhydrodynamic delivery of DNA to hepatocyte nuclei in vivo
Q51015389A tailor-made specific anion-binding motif in the side chain transforms a tetrapeptide into an efficient vector for gene delivery.
Q34479518A truncated HGP peptide sequence that retains endosomolytic activity and improves gene delivery efficiencies
Q36047076Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells
Q58215331Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems
Q35798425Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems
Q39513734Advanced materials for co-delivery of drugs and genes in cancer therapy
Q38028961Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery
Q39606404Alginate-graft-PEI as a gene delivery vector with high efficiency and low cytotoxicity.
Q37270658Alkane-modified short polyethyleneimine for siRNA delivery
Q40463092Alkyl cross-linked low molecular weight polypropyleneimine dendrimers as efficient gene delivery vectors.
Q42274452Amphiphilic polyethylenimine polymers mediate efficient delivery of DNA and siRNA in mammalian cells
Q58215338An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo
Q35091789Application of magnetic nanoparticles to gene delivery
Q88175987Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments
Q37679156Bioengineered nanoparticles for siRNA delivery
Q37793942Biomedical applications of dendrimers: a tutorial
Q34072540Biophysical characterization of copolymer-protected gene vectors.
Q38161927Bioreducible polycations as shuttles for therapeutic nucleic acid and protein transfection.
Q37763677Bioresponsive polymers for the delivery of therapeutic nucleic acids.
Q33585496Cationic poly(amidoamine) dendrimer induces lysosomal apoptotic pathway at therapeutically relevant concentrations
Q37747047Cellular endocytosis and gene delivery
Q42582978Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells
Q34030709Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects
Q35161114Characterization and compatibility of hydroxyethyl starch-polyethylenimine copolymers for DNA delivery
Q33796040Chemical induction of misfolded prion protein conformers in cell culture.
Q58322949Chemistry specificity of DNA–polycation complex salt response: a simulation study of DNA, polylysine and polyethyleneimine
Q38122934Chitosans for delivery of nucleic acids.
Q38189091Classification of stimuli-responsive polymers as anticancer drug delivery systems.
Q39417286Co-localization of fluorescent labeled lipid nanoparticles with specifically tagged subcellular compartments by single particle tracking at low nanoparticle to cell ratios
Q38847729Combination of sequence-defined oligoaminoamides with transferrin-polycation conjugates for receptor-targeted gene delivery
Q37142739Combinatorial and rational approaches to polymer synthesis for medicine
Q92357776Coming in and Finding Out: Blending Receptor-Targeted Delivery and Efficient Endosomal Escape in a Novel Bio-Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells
Q34445374Comparative studies of polyethylenimine-doxorubicin conjugates with pH-sensitive and pH-insensitive linkers.
Q41585561Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery
Q45152813Comparison between polyethylene glycol- and polyethylenimine-mediated transformation of Aspergillus nidulans
Q58836342Comparison of chitosan, alginate and chitosan/alginate nanoparticles with respect to their size, stability, toxicity and transfection
Q38221915Complexity in the therapeutic delivery of RNAi medicines: an analytical challenge.
Q57564390Composite vector formulation for multiple siRNA delivery as a host targeting antiviral in a cell culture model of hepatitis C virus (HCV) infection
Q38332480Control of stem cell fate by engineering their micro and nanoenvironment.
Q39026289Correlation of length of linear oligo(ethanamino) amides with gene transfer and cytotoxicity
Q44361270Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo
Q51797571Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans.
Q30574647Cyclodextrin and polyethylenimine functionalized mesoporous silica nanoparticles for delivery of siRNA cancer therapeutics
Q37403716Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles
Q37695703D-glucosamine conjugation accelerates the labeling efficiency of quantum dots in osteoblastic cells
Q42155861Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing
Q45873174Defined pH-sensitive nanogels as gene delivery platform for siRNA mediated in vitro gene silencing
Q38345348Defined polymeric materials for gene delivery
Q38350140Degradable polymers for gene delivery
Q26828423Dendrimer advances for the central nervous system delivery of therapeutics
Q84755402Dendrimer-Based Drug Delivery Systems for Brain Targeting
Q57610427Dendrimer-Based Gene Delivery Systems: Administration Routes andIn VivoEvaluation
Q42180868Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery
Q41734074Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy.
Q38974213Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides
Q50268214Dendrosome-dendriplex inside liposomes: as a gene delivery system.
Q35587531Dependence of PEI and PAMAM Gene Delivery on Clathrin- and Caveolin-Dependent Trafficking Pathways
Q36211579Design and development of polymers for gene delivery
Q39714505Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery
Q35812875Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens
Q35112531Design of a multicomponent peptide-woven nanocomplex for delivery of siRNA.
Q30939817Design of amine-modified graft polyesters for effective gene delivery using DNA-loaded nanoparticles
Q50933982Design of pH-sensitive peptides from natural antimicrobial peptides for enhancing polyethylenimine-mediated gene transfection.
Q35538371Designing multifunctional quantum dots for bioimaging, detection, and drug delivery
Q38761724Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery
Q96111679Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons
Q64893160Development of CS-TPP-dsRNA nanoparticles to enhance RNAi efficiency in the yellow fever mosquito, Aedes aegypti.
Q39506235Development of lipidoid-siRNA formulations for systemic delivery to the liver
Q42723857Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells
Q94547561Digesting the crisis: autophagy and coronaviruses
Q27339704Direct cytosolic delivery of siRNA using nanoparticle-stabilized nanocapsules
Q33993334Discovery of cationic polymers for non-viral gene delivery using combinatorial approaches
Q41197665Diseases originate and terminate by genes: unraveling nonviral gene delivery
Q36275628Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection
Q39616606Disulfide-based poly(amido amine)s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity
Q33713938Drug delivery-mediated control of RNA immunostimulation
Q37804385Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery
Q37771030Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery (review).
Q37094403ENDOCYTOSIS PATHWAYS FOR NUCLEIC ACID THERAPEUTICS.
Q36148560Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α.
Q38322009Effective antitumor gene therapy delivered by polyethylenimine-conjugated stearic acid-g-chitosan oligosaccharide micelles
Q37270647Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
Q45861517Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles
Q33877287Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization.
Q37702232Electrostatic surface modifications to improve gene delivery.
Q38201455Emerging Applications of Polymersomes in Delivery: from Molecular Dynamics to Shrinkage of Tumors.
Q37850686Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery
Q26996159Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems
Q36580613Emerging vectors and targeting methods for nonviral gene therapy.
Q37990464Endocytosis at the nanoscale
Q33300327Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation
Q37205125Engineering nano- and microparticles to tune immunity
Q34418330Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics
Q54263978Enhanced Delivery of Therapeutic siRNA into Glioblastoma Cells Using Dendrimer-Entrapped Gold Nanoparticles Conjugated with β-Cyclodextrin.
Q61703770Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes
Q38894686Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines
Q39396815Enhanced gene delivery using Bubble liposomes and ultrasound for folate-PEG liposomes
Q35675219Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-L-lysine
Q38954941Enhancement of anti-tumor immune responses by transfection of IFNγ gene into tumor using a novel type synthetic vector.
Q38212473Enhancing endosomal escape for nanoparticle mediated siRNA delivery
Q36393984Enhancing microparticle internalization by nonphagocytic cells through the use of noncovalently conjugated polyethyleneimine
Q35624010Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials.
Q37560183Environmentally responsive peptides as anticancer drug carriers
Q34148160Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles.
Q37258701Exploiting endocytosis for nanomedicines
Q38989829Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW.
Q36555626Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.
Q51766986Fluorescence ratiometric detection of ligand-induced receptor internalization using extracellular coiled-coil tag-probe labeling.
Q42158208Fluorescent dye incorporation causes weakened gene association and intracellular aggregate formation in nonviral carriers
Q41874912Fluorescent nanosensors for intracellular measurements: synthesis, characterization, calibration, and measurement.
Q36053120Formation and intracellular trafficking of lipoplexes and polyplexes
Q43143238Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides
Q37378143Fourth generation phosphorus-containing dendrimers: prospective drug and gene delivery carrier.
Q33936962Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung
Q61013237Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability
Q36613594Gene delivery by cationic lipid vectors: overcoming cellular barriers
Q40268859Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles
Q38297124Gene therapy and imaging in preclinical and clinical oncology: recent developments in therapy and theranostics
Q38741842HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight
Q38200096Hepatic RNA Interference: Delivery by Synthetic Vectors
Q37404528High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics
Q28394137Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain
Q34626825Highly compacted pH-responsive DNA nanoparticles mediate transgene silencing in experimental glioma
Q38759514History of Polymeric Gene Delivery Systems
Q40689442How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides
Q57610433Hydration forces as a tool for the optimization of core–shell nanoparticle vectors for cancer gene therapy
Q36702382Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells
Q34386810Identification and characterization of receptor-specific peptides for siRNA delivery
Q45876304Identification of magnetic nanoparticles for combined positioning and lentiviral transduction of endothelial cells
Q33279955Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library
Q35612571Image-guided tumor-selective radioiodine therapy of liver cancer after systemic nonviral delivery of the sodium iodide symporter gene
Q37038838Imaging gene delivery with fluorescence microscopy
Q38710046Imaging-guided delivery of RNAi for anticancer treatment
Q64104434Improving Magnetofection of Magnetic Polyethylenimine Nanoparticles into MG-63 Osteoblasts Using a Novel Uniform Magnetic Field
Q33995808In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency
Q39574217In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles
Q39702833Incorporation of 2,3-diaminopropionic acid into linear cationic amphipathic peptides produces pH-sensitive vectors
Q34474842Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds
Q38914284Inflammation responsive logic gate nanoparticles for the delivery of proteins.
Q93006603Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Shielding of pDNA Nanoparticles
Q38862282Influence of oligospermines architecture on their suitability for siRNA delivery
Q41987139Influence of the molecular weight of bioreducible oligoethylenimine conjugates on the polyplex transfection properties
Q34594717Interactions of a charged nanoparticle with a lipid membrane: implications for gene delivery
Q37121611Internally cationic polyamidoamine PAMAM-OH dendrimers for siRNA delivery: effect of the degree of quaternization and cancer targeting
Q42093781Interplay of polyethyleneimine molecular weight and oligonucleotide backbone chemistry in the dynamics of antisense activity
Q35194084Intracellular fates of cell-penetrating block copolypeptide vesicles.
Q36218205Intracellular trafficking of nonviral vectors
Q51052987Intracellular triggered release of DNA-quaternary ammonium polyplex by ultrasound.
Q36689670Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus
Q58781604Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery
Q34155795Lipid and polymeric carrier-mediated nucleic acid delivery
Q37670986Lipid-based nanotherapeutics for siRNA delivery
Q37425606Lipid-based systemic delivery of siRNA.
Q41897699Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery
Q35544272Lipophilic tetranuclear ruthenium(II) complexes as two-photon luminescent tracking non-viral gene vectors
Q37427321Macropinocytosis is the major pathway responsible for DNA transfection in CHO cells by a charge-reversal amphiphile
Q40528522Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells
Q28247202Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects
Q35133892Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane.
Q39075571Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity
Q30417239Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles
Q33908258Maximizing the Supported Bilayer Phenomenon: Liposomes Comprised Exclusively of PEGylated Phospholipids for Enhanced Systemic and Lymphatic Delivery
Q84969771Medicinal Chemistry of siRNA Delivery
Q35911766Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes
Q43860458Mitigated cytotoxicity and tremendously enhanced gene transfection efficiency of PEI through facile one-step carbamate modification
Q36070661Mitochondria-Targeting Magnetic Composite Nanoparticles for Enhanced Phototherapy of Cancer
Q38248247Modeling the interaction between dendrimers and nucleic acids: a molecular perspective through hierarchical scales.
Q39759130Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling
Q62049234Modular Synthesis of Bioreducible Gene Vectors through Polyaddition of N,N′-Dimethylcystamine and Diglycidyl Ethers
Q37373484Molecular dynamics simulations of DNA-polycation complex formation
Q58454521Molecular dynamics study of charged dendrimers in salt-free solution: Effect of counterions
Q38837880Monoolein-based nanocarriers for enhanced folate receptor-mediated RNA delivery to cancer cells
Q34276290Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy
Q39657677Multiresponse strategies to modulate burst degradation and release from nanoparticles
Q38870585Multivalent Polymer Nanocomplex Targeting Endosomal Receptor of Immune Cells for Enhanced Antitumor and Systemic Memory Response
Q57528968N1-Benzylidene-N2-(2-((2-((2-(benzylideneamino)ethyl)amino) ethyl)amino)ethyl)ethane-1,2-diamine
Q64949843Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles.
Q37891091Nanocarriers: a tool to overcome biological barriers in siRNA delivery.
Q33483926Nanodelivery in airway diseases: challenges and therapeutic applications
Q36809026Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face?
Q57282212Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Therapeutics
Q35843512Nanoparticle-based technologies for retinal gene therapy
Q33622573Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis
Q23909949Nanoparticulates
Q33326762Nanopolymers improve delivery of exon skipping oligonucleotides and concomitant dystrophin expression in skeletal muscle of mdx mice
Q36024721Nanoscaled buffering zone of charged (PLGA)n-b-bPEI micelles in acidic microclimate for potential protein delivery application
Q23909945Nanotechnology: toxicologic pathology
Q42562347Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies.
Q38168518Non-Viral Delivery and Therapeutic Application of Small Interfering RNAs
Q58728426Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers
Q36650331Non-viral gene therapy for spinal cord regeneration
Q38849963Non-viral nucleic acid containing nanoparticles as cancer therapeutics
Q36801846Non-viral siRNA delivery to the lung
Q90380886Non-viral transfection vectors: are hybrid materials the way forward?
Q37526991Non-viral vectors in cystic fibrosis gene therapy: recent developments and future prospects
Q36969152Nonviral approaches for neuronal delivery of nucleic acids.
Q30479098Nonviral gene delivery: principle, limitations, and recent progress
Q36780064Nonviral gene delivery: what we know and what is next
Q37780317Nonviral gene transfer as a tool for studying transcription regulation of xenobiotic metabolizing enzymes
Q38722859Novel PEI/Poly-γ-Gutamic Acid Nanoparticles for High Efficient siRNA and Plasmid DNA Co-Delivery
Q37369240Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity
Q35423394Novel cationic triblock copolymer of poly[2-(dimethylamino)ethyl methacrylate]-block-poly(β-amino ester)-block-poly[2-(dimethylamino)ethyl methacrylate]: a promising non-viral gene delivery system.
Q45872167Novel degradable oligoethylenimine acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer
Q57371923Novel poly(glycidyl methacrylate-b-propylene oxide-b-glycidyl methacrylate) derivatives with low cytotoxicity and efficient gene delivery
Q26851886Nucleic acid delivery: the missing pieces of the puzzle?
Q37981217Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression
Q36690285Optimization and delivery of plasmid DNA for vaccination
Q35809590Optimized dextran-polyethylenimine conjugates are efficient non-viral vectors with reduced cytotoxicity when used in serum containing environments
Q28476268Optimizing targeted gene delivery: chemical modification of viral vectors and synthesis of artificial virus vector systems
Q38888264Ovarian cancer immunotherapy using PD-L1 siRNA targeted delivery from folic acid-functionalized polyethylenimine: strategies to enhance T cell killing.
Q90330557Overcoming Endosomal Entrapment in Drug Delivery
Q33894609PEG-polypeptide block copolymers as pH-responsive endosome-solubilizing drug nanocarriers
Q34054137PEGylated polyamidoamine dendrimers with bis-aryl hydrazone linkages for enhanced gene delivery.
Q49920174PSMA-targeted polyinosine/polycytosine vector induces prostate tumor regression and invokes an antitumor immune response in mice.
Q26798005PTH receptor-1 signalling-mechanistic insights and therapeutic prospects
Q37621562Pancreatic cancer: gene therapy approaches and gene delivery systems
Q38871170Peptide GE11-Polyethylene Glycol-Polyethylenimine for targeted gene delivery in laryngeal cancer
Q41503307Peptide-modified vectors for nucleic acid delivery to neurons
Q89782641Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
Q40499765Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes
Q39441748Plant viral and bacteriophage delivery of nucleic acid therapeutics
Q30834674Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier
Q38156233Poly(amidoamine) dendrimer complexes as a platform for gene delivery.
Q40753111Poly(beta-amino esters): procedures for synthesis and gene delivery
Q36759358Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo
Q31020760Poly(β-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies
Q53189780Polyamidoamine dendron-bearing lipid assemblies: their morphologies and gene transfection ability.
Q33893424Polybasic Nanomatrices Prepared By UV-initiated Photopolymerization
Q36150428Polycation-mediated delivery of siRNAs for prophylaxis and treatment of influenza virus infection
Q38339945Polyetheylenimine-polyplexes of Spiegelmer NOX-A50 directed against intracellular high mobility group protein A1 (HMGA1) reduce tumor growth in vivo
Q38306977Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens
Q42176693Polyethyleneimine-lipid conjugate-based pH-sensitive micellar carrier for gene delivery
Q30801495Polyethylenimine (PEI).
Q34982118Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea
Q41985187Polyethylenimine-mediated gene delivery to the lung and therapeutic applications.
Q30490915Polymer beacons for luminescence and magnetic resonance imaging of DNA delivery
Q33565296Polymeric Materials for Gene Delivery and DNA Vaccination
Q37002661Polymers for DNA delivery.
Q57920735Polymers in gene therapy technology
Q57645175Polymersome-Loaded Capsules for Controlled Release of DNA
Q39169193Polyplex Evolution: Understanding Biology, Optimizing Performance
Q39622189Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer
Q89126425Prazosin induced lysosomal tubulation interferes with cytokinesis and the endocytic sorting of the tumour antigen CD98hc
Q48239032Precisely Defined Polymers for Efficient Gene Delivery.
Q34609262Probing the in vitro mechanism of action of cationic lipid/DNA lipoplexes at a nanometric scale
Q39969732Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging
Q37394845Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection
Q40027542Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET.
Q42138120Quantum dot-amphipol nanocomplex for intracellular delivery and real-time imaging of siRNA.
Q89823337Rational design of block copolymer self-assemblies in photodynamic therapy
Q37959311Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses.
Q30510613Real-time gene delivery vector tracking in the endo-lysosomal pathway of live cells
Q34165321Recent In Vivo Evidences of Particle-Based Delivery of Small-Interfering RNA (siRNA) into Solid Tumors
Q57348257Recent progress in cationic polymeric gene carriers for cancer therapy
Q30456053Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting
Q36116663Reducible poly(2-dimethylaminoethyl methacrylate): synthesis, cytotoxicity, and gene delivery activity
Q46221463Release of cationic polymer-DNA complexes from the endosome: A theoretical investigation of the proton sponge hypothesis
Q88477326Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice
Q37651101SRL-Coated PAMAM Dendrimer Nano-Carrier for Targeted Gene Delivery to the Glioma Cells and Competitive Inhibition by Lactoferrin
Q33907953Self-assembled lipid nanomedicines for siRNA tumor targeting.
Q58324581Shape-Persistent and Adaptive Multivalency: Rigid Transgeden (TGD) and Flexible PAMAM Dendrimers for Heparin Binding
Q39301867Single siRNA nanocapsules for enhanced RNAi delivery
Q84778634Smart DNA vectors based on cyclodextrin polymers: compaction and endosomal release
Q40448608Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages.
Q37793079Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles
Q39381829Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery
Q42678907Stability of dendriplexes formed by anti-HIV genetic material and poly(propylene imine) dendrimers in the presence of glucosaminoglycans
Q37731545Stimuli-responsive smart nanogels for cancer diagnostics and therapy
Q38032480Stimulus-responsive nanopreparations for tumor targeting
Q37672410Strategies for delivery of therapeutics into the central nervous system for treatment of lysosomal storage disorders
Q34004838Strategies to improve drug delivery across the blood-brain barrier
Q39127976Strategies to reduce the intracellular effects of iron oxide nanoparticle degradation.
Q39891354Structural and functional consequences of poly(ethylene glycol) inclusion on DNA condensation for gene delivery
Q41914673Structure Dependence of Lysosomal Transit of Chitosan-Based Polyplexes for Gene Delivery
Q34088662Studies on guanidinated N-3-aminopropyl methacrylamide-N-2-hydroxypropyl methacrylamide co-polymers as gene delivery carrier
Q64098755Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers
Q57372254Switchable Materials Containing Polyzwitterion Moieties
Q61450204Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1
Q39187821Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles
Q51035551Synthesis and Preliminary Biological Evaluations of Fluorescent or 149Promethium Labeled Trastuzumab-Polyethylenimine.
Q33601685Synthesis and characterization of biodegradable HPMA-oligolysine copolymers for improved gene delivery
Q41490669Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells.
Q33862942Targeted cellular uptake and siRNA silencing by quantum-dot nanoparticles coated with β-cyclodextrin coupled to amino acids
Q37902117Targeted siRNA delivery to diseased microvascular endothelial cells: cellular and molecular concepts.
Q36293332Targeting of polyplexes: toward synthetic virus vector systems
Q35076012The effect of 5'-adenylic acid on hepatic proteome of mice radiated by 60Co γ-ray
Q40231070The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type
Q39720959The involvement of microtubules and actin filaments in the intracellular transport of non-viral gene delivery system.
Q34389925The modification of siRNA with 3' cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes
Q42541130The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH.
Q30504481The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures
Q41835210Tissue distribution of DNA-Hsp65/TDM-loaded PLGA microspheres and uptake by phagocytic cells
Q44940377Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
Q36068277Towards safe, non-viral therapeutic gene expression in humans.
Q33684568Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells
Q39849558Transfection efficiency of 25-kDa PEI-cholesterol conjugates with different levels of modification
Q39099315Transient mammalian cell transfection with polyethylenimine (PEI).
Q45303665Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
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