Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients

scientific article published in March 2002

Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1056-8727(01)00175-1
P698PubMed publication ID12039395

P2093author name stringYasushi Saito
Nobuhiro Yamada
Tomoichiro Asano
Masanobu Kawakami
Fidarestat Clinical Pharmacology Study Group
P2860cites workThe effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research GroupQ27861088
Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in DiabetesQ28257146
Effects of aldose reductase inhibitor (ONO-2235) on human erythrocyte sorbitol concentrations in 75 g oral glucose tolerance testsQ28333388
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patientsQ28342183
Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjectsQ28572164
Diabetic neuropathies: features and mechanisms.Q33603470
Hyperglycemia, Polyol Metabolism, and Complications of Diabetes MellitusQ38120921
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytesQ43612929
Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group studyQ43748985
Oxygen affinity of hemoglobin and peripheral nerve degeneration in experimental diabetesQ70155946
Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in ratsQ71489787
Biochemical factors influencing erythrocyte deformability and capillary entrance phenomenaQ72029100
Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathyQ73049405
Inhibitory effects of fidarestat on aldose reductase and aldehyde reductase activity evaluated by a new method using HPLC with post-column spectrophotometric detectionQ73519819
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in ratsQ74228997
P433issue2
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)133-138
P577publication date2002-03-01
P1433published inJournal of Diabetes and its ComplicationsQ15763696
P1476titleFidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients
P478volume16