Reversible covalent inhibition of eEF-2K by carbonitriles.

scientific article

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Reversible covalent inhibition of eEF-2K by carbonitriles. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CBIC.201402321
P932PMC publication ID6482285
P698PubMed publication ID25224652

P50authorPengyu RenQ45710729
Jiney JoseQ61822666
P2093author name stringChunli Yan
Yue Shi
Qiantao Wang
Kevin N Dalby
Ashwini K Devkota
Tamer S Kaoud
Eun Jeong Cho
Ramakrishna Edupuganti
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The Role of Eukaryotic Elongation Factor 2 Kinase in Rapid Antidepressant Action of KetamineQ28276943
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongationQ28291406
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Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancerQ34387697
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Alpha-kinases: analysis of the family and comparison with conventional protein kinasesQ35721480
Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli.Q36075643
Activated ERK2 Is a Monomer in Vitro with or without Divalent Cations and When Complexed to the Cytoplasmic Scaffold PEA-15Q36107198
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Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancerQ36617301
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1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitorQ39454084
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Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagyQ39879662
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Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell linesQ40622035
Transient inhibition of protein synthesis induces expression of proto-oncogenes and stimulates resting cells to enter the cell cycleQ41263722
Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.Q42750517
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Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporineQ54216581
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P433issue16
P304page(s)2435-2442
P577publication date2014-09-15
P1433published inChemBioChemQ634395
P1476titleReversible covalent inhibition of eEF-2K by carbonitriles
P478volume15

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cites work (P2860)
Q54978227Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin.
Q27727833Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase
Q38931379Targeted Covalent Inhibitors for Drug Design.
Q40608421Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

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