Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone.

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Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone. is …
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scholarly articleQ13442814

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P356DOI10.1016/S0162-0134(02)00419-1
P698PubMed publication ID12121788

P50authorMichael A. JakupecQ38800373
Bernhard K. KepplerQ38800395
Vladimir B ArionQ88284603
Markus GalanskiQ92637357
P2093author name stringPeter Unfried
P2860cites workChemistry and pharmacokinetics of gallium maltolate, a compound with high oral gallium bioavailabilityQ21284460
Novel thiosemicarbazones derived from formyl- and acyldiazines: synthesis, effects on cell proliferation, and synergism with antiviral agentsQ28327663
Antiviral Activity of 2-Acetylpyridine Thiosemicarbazones Against Herpes Simplex VirusQ28366097
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activityQ33724511
Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current statusQ35836996
Inhibition of ribonucleotide reductase by alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazonesQ40183269
Ribonucleotide reductase: an important enzyme in the replication of herpes simplex virus type 1 and a target for antiviral chemotherapyQ41301050
Selective inhibition of herpes simplex virus ribonucleoside diphosphate reductase by derivatives of 2-acetylpyridine thiosemicarbazoneQ41365986
Effect of gallium on the tyrosyl radical of the iron-dependent M2 subunit of ribonucleotide reductaseQ41589641
The enzyme ribonucleotide reductase: target for antitumor and anti-HIV therapyQ41687656
Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig modelQ42205956
2-Acetylpyridine thiosemicarbazones. 4. Complexes with transition metals as antimalarial and antileukemic agentsQ42256821
Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazinesQ43639529
Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.Q54061261
Comparative cytotoxic and biochemical effects of ligands and metal complexes of .alpha.-N-heterocyclic carboxaldehyde thiosemicarbazonesQ66974045
Non-platinum chemotherapeutic metallopharmaceuticalsQ77367185
P433issue1
P921main subjectgalliumQ861
P304page(s)298-305
P577publication date2002-07-01
P1433published inJournal of Inorganic BiochemistryQ3186919
P1476titleSynthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone
P478volume91

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cites work (P2860)
Q39723471A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cells
Q42703871Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]
Q42353706Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules
Q39704042Cytotoxicity, apoptosis and study of the DNA-binding properties of bi- and tetranuclear gallium(III) complexes with heterocyclic thiolato ligands.
Q42713282Gallium(III) complexes with 2-acetylpyridine-derived thiosemicarbazones: antimicrobial and cytotoxic effects and investigation on the interactions with tubulin
Q36616612Gallium-containing anticancer compounds
Q35928856Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones
Q36568904Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes
Q33965885Medical applications and toxicities of gallium compounds
Q91913177Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review
Q56996887One Pot Synthesis, Photophysical and X-ray Studies of Novel Highly Fluorescent Isoquinoline Derivatives with Higher Antibacterial Efficacy Based on the In-vitro and Density Functional Theory
Q42029282Preparation and biodistribution studies of a radiogallium-acetylacetonate bis (thiosemicarbazone) complex in tumor-bearing rodents
Q59054690Synthesis andIn VitroandIn VivoEvaluation of a New68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
Q34035054Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes
Q45924256The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques.

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