Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease

scientific article published in January 2002

Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0306-4522(02)00204-X
P698PubMed publication ID12150782

P50authorEdwin Hillel KolodnyQ115923107
Thomas WisniewskiQ41043812
P2093author name stringWang ZH
Ji Y
Raksadawan N
Pastores GM
Zeng B
Shan W
P2860cites workBrain-derived neurotrophic factor suppresses programmed death of cerebellar granule cells through a posttranslational mechanismQ73313633
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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's diseaseQ34065279
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Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.Q35374311
Brain-derived neurotrophic factor-transduced fibroblasts: production of BDNF and effects of grafting to the adult rat brain.Q37260489
The causes of Parkinson's disease are being unraveled and rational neuroprotective therapy is close to realityQ40842068
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's diseaseQ40846012
Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's diseaseQ40861090
The use of nonneuronal cells for gene deliveryQ40911146
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Correlation of glioma cell regression with inhibition of insulin-like growth factor 1 and insulin-like growth factor-binding protein-2 expressionQ41088988
An Acid-Treatment Method for the Enhanced Detection of GDNF in Biological SamplesQ41107033
Dopaminergic neurons protected from degeneration by GDNF gene therapyQ41128316
GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine.Q41143148
Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNAQ41649774
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanismQ42438471
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylaseQ43185222
Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transferQ44694208
Toward autologous ex vivo gene therapy for the central nervous system with human adult astrocytesQ45856349
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan diseaseQ45869225
Gene therapy of Parkinson disease model rat by direct injection of plasmid DNA-lipofectin complexQ45876100
Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's diseaseQ45876215
Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.Q45876510
Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic miceQ45889665
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alphaQ48136963
Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action.Q48231010
Dopaminergic neurons degenerate by apoptosis in Parkinson's disease.Q48255275
Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione systemQ48459449
Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neuronsQ48578988
Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterningQ48644054
Prevention of apoptotic motoneuron death in vitro by neurotrophins and muscle extractQ48654234
Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells.Q48705309
Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra.Q48765090
Signaling pathways and survival effects of BDNF and NT-3 on cultured cerebellar granule cellsQ48859167
Time course of striatal changes induced by 6-hydroxydopamine lesion of the nigrostriatal pathway, as studied by combined evaluation of rotational behaviour and striatal Fos expression.Q49137803
Tetrahydrobiopterin in Striatum: Localization in Dopamine Nerve Terminals and Role in Catecholamine SynthesisQ49156811
Gene therapy for Parkinson's diseaseQ60360924
Histochemical detection of apoptosis in Parkinson's disease.Q67401850
6-Hydroxydopamine Lesion of the Rat Substantia Nigra: Time Course and Morphology of Cell DeathQ71799443
Decarboxylation of L-dopa by cultured mouse astrocytesQ72707627
Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesionQ73131503
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectastrocyteQ502961
P304page(s)629-640
P577publication date2002-01-01
P1433published inNeuroscienceQ15708571
P1476titleTherapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease
P478volume113

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cites work (P2860)
Q48769891BDNF promotes human neural stem cell growth via GSK-3β-mediated crosstalk with the wnt/β-catenin signaling pathway
Q34358267Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum
Q44195362Brain-derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/β-catenin signaling pathway
Q30394681Neuromolecular imaging, a nanobiotechnology for Parkinson's disease: advancing pharmacotherapy for personalized medicine
Q34473733Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf
Q26827281Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases
Q38645464Real Time Imaging of Biomarkers in the Parkinson's Brain Using Mini-Implantable Biosensors. II. Pharmaceutical Therapy with Bromocriptine
Q48867401Task-related variations in the surface EMG of the human first dorsal interosseous muscle
Q44343767The delta-opioid receptor agonist (+)BW373U86 regulates BDNF mRNA expression in rats
Q39668035The effect of lentivirus-mediated TH and GDNF genetic engineering mesenchymal stem cells on Parkinson's disease rat model
Q51591930The effect of stimulated microglia conditioned media on BDNF gene expression of striatal astrocytes: quantification by real-time PCR.
Q45042264Transplanted bone marrow stromal cells migrate, differentiate and improve motor function in rats with experimentally induced cerebral stroke.
Q35599603Use of gene therapy in central nervous system repair

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