Alternative splicing of the 5'-sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic lateral sclerosis

scientific article published in August 2002

Alternative splicing of the 5'-sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic lateral sclerosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1471-4159.2002.01012.X
P698PubMed publication ID12153483
P5875ResearchGate publication ID11228465

P50authorBernhard LandwehrmeyerQ42047023
Albert C. LudolphQ67390363
P2093author name stringS Stamm
T Meyer
B Zhu
C Münch
B Schwalenstöcker
M Ebstein
U Seefried
P2860cites workExcitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductanceQ24313586
An excitatory amino-acid transporter with properties of a ligand-gated chloride channelQ24323343
Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated regionQ24597391
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisQ28131805
Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brainQ28141608
Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controlsQ28143392
Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical studyQ28260466
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosisQ28267385
In vivo half-life of a protein is a function of its amino-terminal residueQ28287702
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1Q28592689
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutationQ29547561
Alternative pre-mRNA splicing: the logic of combinatorial controlQ29615087
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundanceQ29615731
Initiation of translation in prokaryotes and eukaryotesQ29618237
Alternative splicing: increasing diversity in the proteomic worldQ29618730
Nonsense-mediated mRNA decay in health and diseaseQ29619553
Tissue specific variants of glutamate transporter GLT-1.Q30090179
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosisQ34300016
The release and uptake of excitatory amino acidsQ37607591
Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampusQ38300706
Initiation codons within 5'-leaders of mRNAs as regulators of translationQ40664332
The 5' UTR of protein kinase C epsilon confers translational regulation in vitro and in vivoQ40805866
Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutaseQ42485699
Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frameQ42619358
Splicing of the glutamate transporter EAAT2: a candidate gene of amyotrophic lateral sclerosisQ42912839
Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levelsQ43809083
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.Q46135324
5'-heterogeneity of the human excitatory amino acid transporter cDNA EAAT2 (GLT-1).Q47959438
Activity-dependent regulation of alternative splicing patterns in the rat brainQ48248567
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporterQ48918632
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectamyotrophic lateral sclerosisQ206901
alternative mRNA splicing, via spliceosomeQ21114084
P304page(s)594-603
P577publication date2002-08-01
P1433published inJournal of NeurochemistryQ6295643
P1476titleAlternative splicing of the 5'-sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic lateral sclerosis
P478volume82

Reverse relations

cites work (P2860)
Q40480300A survey of splice variants of the human hypoxanthine phosphoribosyl transferase and DNA polymerase beta genes: products of alternative or aberrant splicing?
Q35154322Association of rare variation in the glutamate receptor gene SLC1A2 with susceptibility to bipolar disorder and schizophrenia.
Q35946030Biomarkers of neurodegenerative disorders: how good are they?
Q46902620Chemical hypoxia facilitates alternative splicing of EAAT2 in presymptomatic APP23 transgenic mice
Q44327960Differential regulation of 5' splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid
Q51824569EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis.
Q36904469EAAT2 regulation and splicing: relevance to psychiatric and neurological disorders
Q51823995Exon array analysis of alternative splicing of genes in SOD1G93A transgenic mice.
Q34181309Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.
Q26861666Glutamate transporter 1: target for the treatment of alcohol dependence
Q34924292Impairment of neuronal glutamate uptake and modulation of the glutamate transporter GLT-1 induced by retinal ischemia
Q43577107Links between electrophysiological and molecular pathology of amyotrophic lateral sclerosis
Q39625408Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration.
Q37495425SLC1 glutamate transporters
Q37168377The four major N- and C-terminal splice variants of the excitatory amino acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies.
Q41693925The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders
Q57372610Translational Control of Glial Glutamate Transporter EAAT2 Expression
Q36052481Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement
Q45246507VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients

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