Synthesis and anticonvulsant activity of enaminones. 4. Investigations on isoxazole derivatives

scientific article published in August 2002

Synthesis and anticonvulsant activity of enaminones. 4. Investigations on isoxazole derivatives is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0223-5234(02)01377-6
P698PubMed publication ID12161061

P2093author name stringDonna S Cox
Raymond J Butcher
Natalie D Eddington
James P Stables
K R Scott
Ivan O Edafiogho
Angela M Goodwin
Carlynn A Smith
Neville Cooke
Ralph R Roberts
P2860cites workModification of seizure activity by electrical stimulation. II. Motor seizureQ28236678
Enaminones-versatile therapeutic pharmacophores. Further advancesQ28372249
Closely spaced recurrent hippocampal seizures elicit two types of heightened epileptogenesis: a rapidly developing, transient kindling and a slowly developing, enduring kindlingQ30465765
Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsantsQ40763029
Antiepileptic drug development: II. Anticonvulsant drug screeningQ45214589
Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug designQ48208266
Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrierQ48241067
The Hippocampal Slice: A System for Studying the Pharmacology of Seizures and for Screening Anticonvulsant DrugsQ48248190
Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolismQ48356189
Potassium, pentylenetetrazol, and anticonvulsants in mouse hippocampal slicesQ48512238
The application of bovine brain microvessel endothelial-cell monolayers grown onto polycarbonate membranes in vitro to estimate the potential permeability of solutes through the blood-brain barrier.Q50590761
Synthesis and anticonvulsant activity of enaminonesQ68004878
Isoxazole derivatives as centrally acting muscle relaxants. II. Synthesis and structure-activity relationship of 3-amino-N-(3-phenyl-5-isoxazolyl)propanamidesQ69542970
Antiepileptic Drug Development ProgramQ70373416
Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluationsQ71751342
Synthesis and anticonvulsant activity of enaminones. 2. Further structure-activity correlationsQ72843742
Nuclear magnetic resonance studies of anticonvulsant enaminonesQ72865210
Synthesis, characterization and anticonvulsant activity of enaminones. Part 6: Synthesis of substituted vinylic benzamides as potential anticonvulsantsQ73346841
Synthesis, characterization, and anticonvulsant activity of enaminones. Part 5: investigations on 3-carboalkoxy-2-methyl-2,3-dihydro-1H-phenothizin-4[10H]-one derivativesQ77926724
P433issue8
P304page(s)635-648
P577publication date2002-08-01
P1433published inEuropean Journal of Medicinal ChemistryQ3008624
P1476titleSynthesis and anticonvulsant activity of enaminones. 4. Investigations on isoxazole derivatives
P478volume37

Reverse relations

cites work (P2860)
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