Biodistribution and persistence of an MVA-vectored candidate HIV vaccine in SIV-infected rhesus macaques and SCID mice

scientific article published in February 2005

Biodistribution and persistence of an MVA-vectored candidate HIV vaccine in SIV-infected rhesus macaques and SCID mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2004.08.050
P698PubMed publication ID15670887

P50authorAndrew James McMichaelQ21165187
P2093author name stringTomás Hanke
Sally A Sharpe
Michael J Dennis
Lindsey A J Powell
Lorraine McLoughlin
Steven J Crome
P2860cites workIdentification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.Q34467405
Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine virusesQ35234767
MVA as a vector for vaccines against HIV-1.Q35851793
Nonreplicating vaccinia vector efficiently expresses recombinant genesQ37299518
Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challengeQ37358213
Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccineQ39589039
Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccineQ41039759
Highly attenuated modified vaccinia virus Ankara replicates in baby hamster kidney cells, a potential host for virus propagation, but not in various human transformed and primary cellsQ41064284
Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell lineQ41076591
Anti-major histocompatibility complex antibody responses to simian B cells do not protect macaques against SIVmac infectionQ41098949
Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulenceQ41684943
Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adultsQ44939076
A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humansQ45661091
Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administrationQ45723808
Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteersQ45723913
Lack of toxicity and persistence in the mouse associated with administration of candidate DNA- and modified vaccinia virus Ankara (MVA)-based HIV vaccines for KenyaQ45730049
Induction of simian immunodeficiency virus (SIV)-specific CTL in rhesus macaques by vaccination with modified vaccinia virus Ankara expressing SIV transgenes: influence of pre-existing anti-vector immunityQ45736005
Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques.Q45737034
Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA.Q45738726
Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in KenyaQ46958770
Comparison of the efficacy of early versus late viral proteins in vaccination against SIVQ56880151
Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individualsQ57081485
Studies on poxvirus infections in irradiated animalsQ72861146
Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regimeQ74601718
P433issue12
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)1507-1514
P577publication date2005-02-01
P1433published inVaccineQ7907941
P1476titleBiodistribution and persistence of an MVA-vectored candidate HIV vaccine in SIV-infected rhesus macaques and SCID mice
P478volume23

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cites work (P2860)
Q36824066A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vector.
Q33945612A novel MVA vectored Chikungunya virus vaccine elicits protective immunity in mice
Q37502368Absence of systemic toxicity changes following intramuscular administration of novel pSG2.HIVconsv DNA, ChAdV63.HIVconsv and MVA.HIVconsv vaccines to BALB/c mice
Q45423126Altered primary CD8+ T cell response to a modified virus Ankara(MVA)-vectored vaccine in the absence of CD4+ T cell help
Q27008256Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination
Q80207648Comparative efficacy of modified vaccinia Ankara (MVA) as a potential replacement smallpox vaccine
Q35113347Different patterns of expansion, contraction and memory differentiation of HIV-1 Gag-specific CD8 T cells elicited by adenovirus type 5 and modified vaccinia Ankara vaccines
Q56564203Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S
Q33635050Efficacy and safety of a modified vaccinia Ankara (MVA) vectored plague vaccine in mice
Q35857708Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination
Q38176419Environmental risk assessment of clinical trials involving modified vaccinia virus Ankara (MVA)-based vectors
Q45325213Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?
Q34017475In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate
Q39876175Increased detection of proliferating, polyfunctional, HIV-1-specific T cells in DNA-modified vaccinia virus Ankara-vaccinated human volunteers by cultured IFN-gamma ELISPOT assay
Q34142869Induction of human immunodeficiency virus type 1-specific T cells by a bluetongue virus tubule-vectored vaccine prime-recombinant modified virus Ankara boost regimen
Q82044309Lessons from IAVI-006, a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers
Q40497816MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults
Q30418570Novel viral vectored vaccines for the prevention of influenza
Q44604745Pharmacokinetics and risk evaluation of DNA vaccine against Schistosoma japonicum
Q36889718Quantitative real-time PCR study on persistence of pDNA vaccine pVax-Hsp60 TM814 in beef muscles
Q45407829Safety and tolerability of recombinant modified vaccinia virus Ankara expressing an HIV-1 gag/multiepitope immunogen (MVA.HIVA) in HIV-1-infected persons receiving combination antiretroviral therapy
Q36225504Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal.
Q80861378Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine
Q43969171Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects
Q35751946Vaccine properties of a novel marker gene-free recombinant modified vaccinia Ankara expressing immunodominant CMV antigens pp65 and IE1.
Q51989059Vaccine route, dose and type of delivery vector determine patterns of primary CD8+ T cell responses.

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