Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins

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Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins is …
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scholarly articleQ13442814

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P356DOI10.1046/J.1365-2826.2002.00836.X
P698PubMed publication ID12213137

P2093author name stringHolsboer F
Uhr M
Müller MB
P2860cites workHippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposureQ28346146
Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruptionQ28372143
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificitiesQ33495468
The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxietyQ33658043
Multiple physiological functions for multidrug transporter P-glycoprotein?Q33818793
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sitesQ33832954
Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's diseaseQ33885755
Mini-review: in vivo neurogenesis in the adult brain: regulation and functional implicationsQ34007390
The corticosteroid receptor hypothesis of depressionQ34057906
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsQ34059522
Control of neuronal excitability by corticosteroid hormonesQ35318038
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteinsQ36108920
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissuesQ36768537
Profound differences in the transport of steroids by two mouse P-glycoproteinsQ40929456
The physiological function of drug-transporting P-glycoproteinsQ41688645
Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.Q43892559
Blood-brain barrier: endogenous modulation by adrenal-cortical functionQ48506183
P433issue9
P921main subjectcortisolQ190875
P1104number of pages7
P304page(s)753-759
P577publication date2002-09-01
P1433published inJournal of NeuroendocrinologyQ3186929
P1476titlePenetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins
P478volume14

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