Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis

scientific article

Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M203873200
P8608Fatcat IDrelease_vxvl7e5xbrfqti3lu2db76njwe
P698PubMed publication ID12215432
P5875ResearchGate publication ID11174601

P50authorTetsuya OkajimaQ37382138
P2093author name stringKoichi Furukawa
Kenneth D Irvine
Takeshi Urano
Jihua Chen
Nicola Haines
Pamela Stanley
Keiko Furukawa
Yoko Nakamura
P2860cites workCloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesisQ22004161
Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathwayQ22008748
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycansQ22010476
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene familyQ22010511
Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I geneQ22010593
Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-IIQ24290566
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)Q24291678
A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3Q24314565
The expanding beta 4-galactosyltransferase gene family: messages from the databanksQ24318549
A genetic defect in the biosynthesis of dermatan sulfate proteoglycan: galactosyltransferase I deficiency in fibroblasts from a patient with a progeroid syndromeQ24559196
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferaseQ24672069
A simple method for displaying the hydropathic character of a proteinQ26778481
Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactoseQ27618915
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesQ27860600
Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functionsQ28139075
Identification of the full-length coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: beta 1,4-galactosyltransferase)Q28291454
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiationQ28296150
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brainQ28581590
Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycansQ28609291
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptorQ29616189
The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wingQ33865508
Proteoglycans and pattern formation: sugar biochemistry meets developmental geneticsQ33899439
Assignment of human xylosylprotein beta-1,4-galactosyltransferase gene (B4GALT7) to human chromosome 5q35.2-->q35.3 by in situ hybridizationQ33909557
Functional binding of secreted molecules to heparan sulfate proteoglycans in DrosophilaQ34026281
sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invaginationQ34941722
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactoseQ35037849
The role of proteoglycans in cell adhesion, migration and proliferationQ35455376
sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesisQ37262651
Organizing spatial pattern in limb developmentQ41275228
Formation of HNK-1 determinants and the glycosaminoglycan tetrasaccharide linkage region by UDP-GlcUA:Galactose beta1, 3-glucuronosyltransferasesQ41613096
Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymesQ43471360
Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling eventsQ43726761
UDP-sugar transporter implicated in glycosylation and processing of NotchQ43726763
Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivoQ47070848
Visualization of gene expression in living adult Drosophila.Q52199397
The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs.Q52202098
Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate ProteoglycanQ52225676
Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila.Q52537316
An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila.Q52558392
Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.Q52567522
Heritable gene silencing in Drosophila using double-stranded RNA.Q52581458
Zwitterionic and acidic glycosphingolipids of the Drosophila melanogaster embryoQ57371151
Unusual beta-D-xylosides that prime glycosaminoglycans in animal cellsQ71245700
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
morphogenesisQ815547
Beta-4-galactosyltransferase 7 Dmel_CG11780Q29818126
P304page(s)46280-46288
P577publication date2002-09-04
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis
P478volume277

Reverse relations

cites work (P2860)
Q39834894A visualizable chain-terminating inhibitor of glycosaminoglycan biosynthesis in developing zebrafish
Q36973762B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1
Q42920436Biochemical and thermodynamic characterization of mutated β1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers–Danlos syndrome
Q33258672Comparative characterisation of recombinant invertebrate and vertebrate peptide O-Xylosyltransferases
Q27660264Crystal Structure of the Catalytic Domain of Drosophila β1,4-Galactosyltransferase-7
Q52684174Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis.
Q44456230Expression of eukaryotic glycosyltransferases in the yeast Pichia pastoris.
Q47070983Functional Characterization of Drosophila Sialyltransferase
Q45162691Functional analysis of Drosophila beta1,4-N-acetlygalactosaminyltransferases
Q46828499Functional analysis of proteoglycan galactosyltransferase II RNA interference mutant flies.
Q30437179Glycobiology on the fly: developmental and mechanistic insights from Drosophila
Q37236002Glycoconjugate glycosyltransferases.
Q47072413Glycosphingolipids with extended sugar chain have specialized functions in development and behavior of Drosophila
Q34271410Glycosylation regulates Notch signalling.
Q37785137Glycosyltransferases and transporters that contribute to proteoglycan synthesis in Drosophila: Identification and functional analyses using the heritable and inducible RNAi system
Q40250674Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter.
Q41714436Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway
Q36723748Molecular cloning and functional characterization of a Lepidopteran insect beta4-N-acetylgalactosaminyltransferase with broad substrate specificity, a functional role in glycoprotein biosynthesis, and a potential functional role in glycolipid biosyn
Q36439174Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI
Q36380216Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing.
Q44318011Proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster
Q30392577Structure-based evolutionary relationship of glycosyltransferases: a case study of vertebrate β1,4-galactosyltransferase, invertebrate β1,4-N-acetylgalactosaminyltransferase and α-polypeptidyl-N-acetylgalactosaminyltransferase
Q33202664The Drosophila melanogaster homologue of the human histo-blood group Pk gene encodes a glycolipid-modifying alpha1,4-N-acetylgalactosaminyltransferase
Q36542361The N's and O's of Drosophila glycoprotein glycobiology
Q38734951ZFX modulates the growth of human leukemic cells via B4GALT1.

Search more.