Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats

scientific article published on 27 June 2002

Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPHEART.00313.2002
P698PubMed publication ID12234790
P5875ResearchGate publication ID11155479

P2093author name stringKeith W Dilly
Silvia Guatimosim
W Jonathan Lederer
Kin M Choi
Brian D Hoit
Yan Zhong
Ingrid L Grupp
Harvey Hahn
Mohammed A Matlib
P2860cites workTargeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulationQ28509802
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortalityQ31920931
Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart AssociationQ33728882
Cellular and functional defects in a mouse model of heart failureQ33925912
Cardiac intracellular calcium release channels: role in heart failureQ33960297
Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure.Q34060513
New type of cardiomyopathy associated with diabetic glomerulosclerosisQ34205051
Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytesQ34464960
The control of calcium release in heart muscleQ36703939
Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes.Q36881477
Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantationQ37307370
Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic miceQ37350650
Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathyQ37385438
Diabetes and thyroid-hormone-induced changes in cardiac function and their molecular basisQ38639872
Phospholamban: a prominent regulator of myocardial contractilityQ40919889
Intracellular calcium levels are unchanged in the diabetic heartQ41526727
Cytosolic Ca2+ concentration decreases in diabetic rat myocytesQ41526737
Transgenic approaches to define the functional role of dual site phospholamban phosphorylationQ42450966
Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heartQ42521720
Altered SR protein expression associated with contractile dysfunction in diabetic rat heartsQ43713882
Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathyQ43935483
Role of diabetes in congestive heart failure: the Framingham studyQ44758886
Sarcoplasmic reticulum in heart failure: central player or bystander?Q48008693
Alterations of calcium-regulatory proteins in heart failureQ48008757
Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (The Framingham Heart Study)Q57604699
P433issue4
P921main subjectcardiomyopathyQ847583
P304page(s)H1398-408
P577publication date2002-06-27
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleDefective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats
P478volume283

Reverse relations

cites work (P2860)
Q37983012A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy
Q34815218ACE-inhibition, but not weight reduction restores cardiomyocyte response to β-adrenergic stimulation in the metabolic syndrome.
Q36193769Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling
Q43154490Alloxan reduces amplitude of ventricular myocyte shortening and intracellular Ca2+ without altering L-type Ca2+ current, sarcoplasmic reticulum Ca2+ content or myofilament sensitivity to Ca2+ in Wistar rats
Q38309620Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance
Q39897078Alterations in sarcoplasmic reticulum and mitochondrial functions in diabetic cardiomyopathy
Q36807692Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy.
Q35940006Altered cardiac calcium handling in diabetes
Q42584147Altered mechanical and electrical activities of the diabetic heart: Possible use of new therapeutics?
Q38653843Altered profile of mRNA expression in atrioventricular node of streptozotocin‑induced diabetic rats.
Q37707579Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions
Q38705779Arrhythmia Vulnerability in Diabetic Cardiac Tissue is Species-Dependent: Effects of I KATP, Uncoupling, and Connexin Lateralization
Q52660233Attenuation of Ca2+ homeostasis, oxidative stress, and mitochondrial dysfunctions in diabetic rat heart: insulin therapy or aerobic exercise?
Q35602720Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis
Q55049902Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat.
Q44643876Calcium homeostasis in rat cardiomyocytes during chronic hypoxia: a time course study
Q28577628Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes
Q36174773Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus.
Q42498213Cardioprotective effect of propranolol on diabetes-induced altered intracellular Ca2+ signaling in rat.
Q46526700Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats
Q43138069Characterization of L-type calcium channel activity in atrioventricular nodal myocytes from rats with streptozotocin-induced Diabetes mellitus
Q46856995Characterization of alterations in diabetic myocardial tissue using high resolution MRI.
Q92852811Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy
Q33357265Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria
Q80114788Decreased cardiac sarcoplasmic reticulum Ca2+ -ATPase activity contributes to cardiac dysfunction in streptozotocin-induced diabetic rats
Q34271053Diabetes alters intracellular calcium transients in cardiac endothelial cells
Q33804265Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation
Q26997062Diabetic cardiomyopathy: bench to bedside
Q28395852Diabetic cardiomyopathy: signaling defects and therapeutic approaches
Q51315241Disbalance of calcium regulation-related genes in broiler hearts induced by selenium deficiency.
Q51434807Early cardiac dysfunction is rescued by upregulation of SERCA2a pump activity in a rat model of metabolic syndrome.
Q45054948Effects of acidosis on ventricular myocyte shortening and intracellular Ca2+ in streptozotocin-induced diabetic rats
Q83047821Effects of carbenoxolone on heart rhythm, contractility and intracellular calcium in streptozotocin-induced diabetic rat
Q42478151Effects of exercise training combined with insulin treatment on cardiac NOS1 signaling pathways in type 1 diabetic rats
Q22241401Effects of gender difference on cardiac myocyte dysfunction in streptozotocin-induced diabetic rats
Q45054945Effects of halothane, isoflurane, sevoflurane and desflurane on contraction of ventricular myocytes from streptozotocin-induced diabetic rats
Q93167935Effects of prolactin on ventricular myocyte shortening and calcium transport in the streptozotocin-induced diabetic rat
Q46400011Effects of single high-dose and multiple low-dose streptozotocin on contraction and intracellular Ca2+ in ventricular myocytes from diabetes resistant and susceptible rats
Q80413608Effects of streptozotocin-induced diabetes on action potentials in the sinoatrial node compared with other regions of the rat heart
Q46482196Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle
Q46540837Effects of varying intensity exercise on shortening and intracellular calcium in ventricular myocytes from streptozotocin (STZ)-induced diabetic rats
Q39670528Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction.
Q36078945Emerging beneficial roles of sirtuins in heart failure.
Q37125035Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes
Q64076654Empagliflozin Attenuates Myocardial Sodium and Calcium Dysregulation and Reverses Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats
Q46725830Endoplasmic reticulum stress is involved in myocardial apoptosis of streptozocin-induced diabetic rats
Q37858336Endoplasmic-reticulum calcium depletion and disease
Q30301118Enhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling
Q36312605Excess protein O-GlcNAcylation and the progression of diabetic cardiomyopathy.
Q37233149Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation
Q37223281Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia
Q28389901Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes
Q44559061Gender differences in myosin heavy chain-beta and phosphorylated phospholamban in diabetic rat hearts
Q45054957Halothane alters contractility and Ca2+ transport in ventricular myocytes from streptozotocin-induced diabetic rats
Q35134241Heart disease in diabetic patients
Q39763308Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Q64375151Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo
Q49989710Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats
Q47943096In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes
Q55399483Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Q43059618Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy
Q42503082Insulin regulation of glutathione and contractile phenotype in diabetic rat ventricular myocytes
Q81565816Interpretation of relevance of sodium-calcium exchange in action potential of diabetic rat heart by mathematical model
Q42517698Intracellular levels of Na(+) and TTX-sensitive Na(+) channel current in diabetic rat ventricular cardiomyocytes
Q51022158Long-term administration of rosuvastatin prevents contractile and electrical remodelling of diabetic rat heart.
Q46642906Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats.
Q35072110Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats.
Q34708259Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic Goto-Kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis
Q36485424Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes
Q36699924Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes
Q38084193Mechanisms of subcellular remodeling in heart failure due to diabetes
Q38234562Mechanisms underlying the impaired contractility of diabetic cardiomyopathy.
Q35057592Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease.
Q53645124Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart.
Q35885059Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: a short review
Q35221216Myocardial performance in conscious streptozotocin diabetic rats
Q46592819Myofilament sensitivity to Ca2+ in ventricular myocytes from the Goto-Kakizaki diabetic rat.
Q36176127Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway
Q38196172Nitric oxide synthase regulation of cardiac excitation-contraction coupling in health and disease
Q47763435Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy
Q58693859Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity
Q37710547Progressive decay of Ca2+ homeostasis in the development of diabetic cardiomyopathy
Q37360093Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats
Q43223828Protective action of doxycycline against diabetic cardiomyopathy in rats
Q37748612Protective role of antioxidants in diabetes-induced cardiac dysfunction
Q37088282Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system.
Q45059479QRS/T-wave and calcium alternans in a type I diabetic mouse model for spontaneous postmyocardial infarction ventricular tachycardia: A mechanism for the antiarrhythmic effect of statins
Q26849625Reactive carbonyl species and their roles in sarcoplasmic reticulum Ca2+ cycling defect in the diabetic heart
Q37710964Regional effects of streptozotocin-induced diabetes on shortening and calcium transport in epicardial and endocardial myocytes from rat left ventricle.
Q42502118Restoration of diabetes-induced abnormal local Ca2+ release in cardiomyocytes by angiotensin II receptor blockade.
Q33727613Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
Q46938364Sarcoplasmic Ca2+ release is prolonged in nonfailing myocardium of diabetic patients
Q46743940Selenium prevents diabetes-induced alterations in [Zn2+]i and metallothionein level of rat heart via restoration of cell redox cycle
Q45216941Short-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats.
Q35130314Significance of AT1 receptor independent activation of mineralocorticoid receptor in murine diabetic cardiomyopathy.
Q52572090Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat.
Q37734628Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae.
Q28582099Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression
Q51542054The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.
Q52146506The Vitamin D Receptor Activator Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus.
Q51389323The chronic effects of neonatal alloxan-induced diabetes mellitus on ventricular myocyte shortening and cytosolic Ca2+
Q37215457The complexities of diabetic cardiomyopathy: lessons from patients and animal models
Q46597569The progressive effects of a fat enriched diet on ventricular myocyte contraction and intracellular Ca2+ in the C57BL/6J mouse
Q37101642Trace elements in diabetic cardiomyopathy: An electrophysiological overview
Q45054950Voltage-dependence of contraction in streptozotocin-induced diabetic myocytes
Q34907705ß-blocker timolol prevents arrhythmogenic Ca²⁺ release and normalizes Ca²⁺ and Zn²⁺ dyshomeostasis in hyperglycemic rat heart

Search more.