Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization

scientific article published on 30 September 2002

Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M207053200
P698PubMed publication ID12359727

P50authorTimothy BilliarQ30223707
P2093author name stringKazuyuki Hatakeyama
Kwon-Soo Ha
Young-Myeong Kim
Young-Guen Kwon
Chun-Ki Kim
Seon-Jin Lee
Peter K M Kim
Hee-Jun Na
Kwang-Soon Lee
Joon-Hong Park
Toshie Yoneyama
P2860cites workGTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expressionQ24311649
Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donorsQ28344914
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activityQ28609889
Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoformQ30990194
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimerQ33722120
Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expressionQ34445999
Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytesQ36058863
An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitroQ36356019
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterinQ39382909
Nitric oxide synthases: properties and catalytic mechanismQ40401516
Redox signaling: nitrosylation and related target interactions of nitric oxideQ40630842
New tetrahydrobiopterin-dependent systemsQ40712561
Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liverQ41104171
Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanismsQ42546244
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.Q42938897
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivoQ43610465
Delayed production of nitric oxide contributes to NMDA-mediated neuronal damage.Q48287382
Nitrosative stress: activation of the transcription factor OxyR.Q54580956
An unusually stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethylethyl thionitriteQ57602513
Growth Factor Regulation of Interleukin-1β-Induced Nitric Oxide Synthase and GTP: Cyclohydrolase Expression in Cultured Smooth Muscle CellsQ60621598
Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian speciesQ70654477
Analysis of reduced forms of biopterin in biological tissues and fluidsQ71136634
Inducible nitric oxide synthase activity in hepatocytes is dependent on the coinduction of tetrahydrobiopterin synthesisQ71609141
Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expressionQ71973760
Tetrahydrobiopterin‐dependent nitrite oxidation to nitrate in isolated rat hepatocytesQ72097607
GTP cyclohydrolase I is coinduced in hepatocytes stimulated to produce nitric oxideQ73067136
Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibitionQ73643152
Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c releaseQ77545246
P433issue49
P407language of work or nameEnglishQ1860
P304page(s)47073-47079
P577publication date2002-09-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleNitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization
P478volume277

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cites work (P2860)
Q35672326'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity
Q37163522A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis
Q40407425Antisense RNA to inducible nitric oxide synthase reduces cytokine-mediated brain endothelial cell death
Q24293818GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
Q35210026Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock
Q35783003Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells
Q40474804S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.
Q33687812Tetrahydrobiopterin in cardiovascular health and disease

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