Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina

scientific article published in December 2002

Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-8993(02)03372-3
P698PubMed publication ID12468025

P2093author name stringHideaki Hara
Yasuo Tano
Yasumasa Otori
Wakana Goto
Kouichi Kawazu
Takashi Ota
Nobuaki Miyawaki
Nobuo Morikawa
P2860cites workThe acute effect of topical beta-adrenoreceptor blocking agents on retinal and optic nerve head circulationQ32068289
Glaucoma, apoptosis, and neuroprotection.Q33575714
Neuroprotection in relation to retinal ischemia and relevance to glaucomaQ33693575
Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucomaQ33693579
Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell deathQ33693595
Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye.Q34537534
The epidemiology of open-angle glaucoma: a reviewQ40154846
Mechanism and pathogenesis of ischemia-induced neuronal damageQ40902525
Effect of the calcium antagonist, nifedipine, on ischemic retinal dysfunction.Q41192602
New approaches to antiglaucoma therapyQ41588329
Free radicals in retinal ischemiaQ41724634
The b-wave of the electroretinogram as an index of retinal ischemiaQ41724639
Effect of timolol versus pilocarpine on visual field progression in patients with primary open-angle glaucomaQ42605745
Interleukin-1beta mediates ischemic injury in the rat retinaQ43826198
Timolol concentrations in rat ocular tissues and plasma after topical and intraperitoneal dosingQ43931568
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in cultureQ46084557
Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retinaQ47771436
Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in cultured retinal neuronsQ49062589
Development of Electroretinographic Alterations in Streptozotocin-lnduced Diabetes in RatsQ52211889
Glutamate neurotoxicity in cortical cell culture.Q54412952
Protective effects of flunarizine on ischemic injury in the rat retinaQ68140166
Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panningQ69933125
Elevated glutamate levels in the vitreous body of humans and monkeys with glaucomaQ70999763
Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and humanQ72413362
Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retinaQ73922338
Memantine reduces alterations to the mammalian retina, in situ, induced by ischemiaQ74449647
Mechanism of the pathogenesis of glutamate neurotoxicity in retinal ischemiaQ77510870
Role of nitric oxide during the initial phase of reperfusion after retinal ischemia in the ratQ77610494
Potential role of nitric oxide and endothelin in the pathogenesis of glaucomaQ78030149
Periocular accumulation of timolol and betaxolol in glaucoma patients under long-term therapyQ78030192
Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to the retinaQ78202522
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)10-19
P577publication date2002-12-01
P1433published inBrain ResearchQ4955782
P1476titleProtective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina
P478volume958

Reverse relations

cites work (P2860)
Q50227757Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models
Q46425617Amelioration of endothelin-1-induced optic nerve head ischemia by topical bunazosin
Q50705613Antioxidant activity of timolol on endothelial cells and its relevance for glaucoma course.
Q44580601Beta-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms
Q45338593Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress.
Q81933494Clinical efficacy of topical nipradilol and timolol on visual field performance in normal-tension glaucoma: a multicenter, randomized, double-masked comparative study
Q37603882Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
Q40196907Effects of beta-adrenergic receptor antagonists on oxidative stress in purified rat retinal ganglion cells.
Q37047848Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells
Q50484130Evaluation of potential topical and systemic neuroprotective agents for ocular hypertension-induced retinal ischemia-reperfusion injury.
Q37034984Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina
Q37236104Hypoxia-ischemia and retinal ganglion cell damage
Q37423557Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury.
Q48250501L-Satropane Prevents Retinal Neuron Damage by Attenuating Cell Apoptosis and Aβ Production via Activation of M1 Muscarinic Acetylcholine Receptor.
Q48241807Lycium barbarum polysaccharide extracts preserve retinal function and attenuate inner retinal neuronal damage in a mouse model of transient retinal ischaemia
Q60476041Neuroprotection in glaucoma
Q33231566Neuroprotective effect of latanoprost on rat retinal ganglion cells
Q46722991Neuroprotective effect of the novel Na+/Ca2+ channel blocker NS-7 on rat retinal ganglion cells
Q24306235Nitric oxide synthase in retina and optic nerve head of rat with increased intraocular pressure and effect of timolol
Q35944015Optic nerve and neuroprotection strategies
Q36735569PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina
Q36770323Pharmacological neuroprotection for glaucoma
Q36048575Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action
Q44360158The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol
Q30848084Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model
Q46690910Toxicity study of erucylphosphocholine in a rat model
Q33212830Unoprostone isopropyl rescues retinal progenitor cells from apoptosis in vitro
Q37799002Use of calcium channel blockers for glaucoma
Q84717318Visual field loss in patients with normal-tension glaucoma under topical nipradilol or timolol: subgroup and subfield analyses of the nipradilol-timolol study

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