Plasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis

scientific article published in October 2005

Plasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1399-3011.2005.00288.X
P698PubMed publication ID16138859
P5875ResearchGate publication ID7622229

P2093author name stringSuguna K
Surolia N
Kesavulu MM
Prakasha Gowda AS
Ramya TN
P2860cites workStructure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparumQ24597864
Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparumQ27640611
Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparumQ30042132
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidineQ30042887
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activityQ31034495
Drug resistance in malariaQ33634459
New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsinsQ33982942
Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.Q34548661
A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparumQ38527989
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytesQ44320304
New inhibitors of the malaria aspartyl proteases plasmepsin I and II.Q44523694
X-ray structure of plasmepsin II complexed with a potent achiral inhibitorQ46445865
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.Q46563187
P433issue4
P921main subjectcrystal structureQ895901
P304page(s)211-219
P577publication date2005-10-01
P1433published inChemical Biology and Drug DesignQ15749458
P1476titlePlasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis
P478volume66

Reverse relations

cites work (P2860)
Q47970644Computational analysis of aspartic protease plasmepsin II complexed with EH58 inhibitor: a QM/MM MD study
Q33961367Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design
Q33257977Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity
Q48031305Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum

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