The c-Fes protein-tyrosine kinase accelerates NGF-induced differentiation of PC12 cells through a PI3K-dependent mechanism

scientific article published in March 2003

The c-Fes protein-tyrosine kinase accelerates NGF-induced differentiation of PC12 cells through a PI3K-dependent mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0898-6568(02)00089-X
P698PubMed publication ID12531426

P2093author name stringThomas E Smithgall
Annemarie Shibata
Charles E Laurent
P2860cites workA point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cellsQ24291572
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factorQ24561804
Neurotrophin signal transduction in the nervous systemQ27876223
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
The c-Fes family of protein-tyrosine kinasesQ28283854
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
The trk proto-oncogene encodes a receptor for nerve growth factorQ28609788
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1Q29620495
BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemiasQ30195698
Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferationQ31839238
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.Q33783562
Regulation of c-Fes tyrosine kinase and biological activities by N-terminal coiled-coil oligomerization domainsQ33960661
Ten years of protein kinase B signalling: a hard Akt to followQ34432885
The Fps/Fes Protein-Tyrosine Kinase Promotes Angiogenesis in Transgenic MiceQ36667579
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cellsQ39450124
The nonreceptor protein-tyrosine kinase c-Fes is involved in fibroblast growth factor-2-induced chemotaxis of murine brain capillary endothelial cellsQ40890115
Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac, and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activationQ41037562
Centrifugal enhancement of retroviral mediated gene transferQ41315284
PI3K: downstream AKTion blocks apoptosisQ41351876
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiationQ41596156
Construction of a cDNA for the human c-fes protooncogene protein-tyrosine kinase and its expression in a baculovirus systemQ43924568
The role of NeuroD as a differentiation factor in the mammalian retina.Q52178373
The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowthQ57903651
Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth FactorQ58197226
Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. Use of Cre/loxP recombination systemQ64382387
Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2Q78208149
P433issue3
P1104number of pages10
P304page(s)279-288
P577publication date2003-03-01
P1433published inCellular SignallingQ1524097
P1476titleThe c-Fes protein-tyrosine kinase accelerates NGF-induced differentiation of PC12 cells through a PI3K-dependent mechanism
P478volume15

Reverse relations

cites work (P2860)
Q40321346A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer
Q35568709Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells
Q45289091Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes
Q41849181Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.
Q24805715Is Melanoma a stem cell tumor? Identification of neurogenic proteins in trans-differentiated cells
Q42526841Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology.
Q47110818Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury
Q44813459PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos
Q24301983The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons
Q33247592The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase
Q24300807The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner
Q24306914The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly
Q40564560Vascular defects in gain-of-function fps/fes transgenic mice correlate with PDGF- and VEGF-induced activation of mutant Fps/Fes kinase in endothelial cells
Q43280614fps/fes knockout mice display a lactation defect and the fps/fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation

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