scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Timothy L. Cover | Q42859723 |
P2093 | author name string | Amber C Beckett | |
Mark S McClain | |||
P2860 | cites work | VacA's Induction of VacA-Containing Vacuoles (VCVs) and Their Immunomodulatory Activities on Human T Cells | Q26744316 |
Relationship between VacA Toxin and Host Cell Autophagy in Helicobacter pylori Infection of the Human Stomach: A Few Answers, Many Questions | Q26744715 | ||
Relationship between vacA Types and Development of Gastroduodenal Diseases | Q26746251 | ||
An Overview of Helicobacter pylori VacA Toxin Biology | Q26748278 | ||
New Insights into VacA Intoxication Mediated through Its Cell Surface Receptors | Q26748950 | ||
Helicobacter pylori Diversity and Gastric Cancer Risk | Q26774217 | ||
Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease | Q27005785 | ||
Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain | Q27648699 | ||
Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs | Q27728476 | ||
The Immunomodulator VacA Promotes Immune Tolerance and Persistent Helicobacter pylori Infection through Its Activities on T-Cells and Antigen-Presenting Cells | Q28067015 | ||
Analysis of surface-exposed outer membrane proteins in Helicobacter pylori. | Q30153404 | ||
Outer membrane targeting of passenger proteins by the vacuolating cytotoxin autotransporter of Helicobacter pylori | Q30167875 | ||
The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH. | Q30303622 | ||
VacA from Helicobacter pylori: a hexameric chloride channel | Q30304025 | ||
Mimicry of a host anion channel by a Helicobacter pylori pore-forming toxin | Q30437777 | ||
A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation | Q30453390 | ||
Helicobacter pylori VacA cytotoxin: a probe for a clathrin-independent and Cdc42-dependent pinocytic pathway routed to late endosomes | Q30476218 | ||
Early endosomes associated with dynamic F-actin structures are required for late trafficking of H. pylori VacA toxin | Q30480427 | ||
Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin. | Q30635465 | ||
Helicobacter pylori VacA Reduces the Cellular Expression of STAT3 and Pro-survival Bcl-2 Family Proteins, Bcl-2 and Bcl-XL, Leading to Apoptosis in Gastric Epithelial Cells | Q39647357 | ||
Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells | Q39671943 | ||
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin | Q39808334 | ||
Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets | Q39830758 | ||
Outer membrane protein expression profile in Helicobacter pylori clinical isolates. | Q39834769 | ||
Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease | Q39936792 | ||
Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan | Q40013873 | ||
Functional association between the Helicobacter pylori virulence factors VacA and CagA. | Q40024074 | ||
Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin | Q40025781 | ||
Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis | Q40091533 | ||
Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy | Q40096295 | ||
Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. | Q40138828 | ||
Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin | Q40214045 | ||
Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms | Q40217600 | ||
Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation | Q40325222 | ||
The cell-specific phenotype of the polymorphic vacA midregion is independent of the appearance of the cell surface receptor protein tyrosine phosphatase beta | Q40337694 | ||
Helicobacter pylori outer membrane protein Q allele distribution is associated with distinct pathologies in Pakistan. | Q40376910 | ||
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release | Q40388328 | ||
Helicobacter pylori toxin VacA is transferred to host cells via a novel contact-dependent mechanism. | Q40602348 | ||
Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. | Q40643877 | ||
Determinants of Non-toxicity in the Gastric Pathogen Helicobacter pylori | Q40648996 | ||
Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo | Q40668540 | ||
Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. | Q40922868 | ||
Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. | Q41069118 | ||
Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers | Q41089116 | ||
Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands | Q41458995 | ||
High resolution structural analysis of Helicobacter pylori VacA toxin oligomers by cryo-negative staining electron microscopy | Q41626935 | ||
Multiple oligomeric states of the Helicobacter pylori vacuolating toxin demonstrated by cryo-electron microscopy | Q41630152 | ||
Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin | Q41653797 | ||
Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease | Q41814225 | ||
Immunosuppressive and proinflammatory activities of the VacA toxin of Helicobacter pylori | Q41844623 | ||
Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil | Q41895124 | ||
Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions. | Q41904051 | ||
Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy | Q42122823 | ||
Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. | Q42603938 | ||
Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration | Q42680016 | ||
Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori | Q42684425 | ||
Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin | Q42772167 | ||
The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. | Q42906330 | ||
Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA. | Q43099779 | ||
Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. | Q43561119 | ||
Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water | Q43812287 | ||
Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts | Q44066924 | ||
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori | Q44087014 | ||
Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin | Q44299992 | ||
Helicobacter pylori CagA and VacA genotypes and gastric phenotype: a meta-analysis | Q44507233 | ||
Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation | Q44586513 | ||
Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma | Q44588813 | ||
Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity | Q44714044 | ||
Cytotoxic activity in broth-culture filtrates of Campylobacter pylori | Q44951898 | ||
Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. | Q46221102 | ||
The effect of Helicobacter pylori on gastric acid secretion by isolated parietal cells from a guinea pig. Association with production of vacuolating toxin by H. pylori | Q46591779 | ||
Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China | Q47887438 | ||
Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori | Q47900027 | ||
Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein | Q48083694 | ||
Characterization of Helicobacter pylori VacA-containing vacuoles (VCVs), VacA intracellular trafficking and interference with calcium signalling in T lymphocytes | Q38863736 | ||
Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells | Q39225246 | ||
Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. | Q39283179 | ||
Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA. | Q39309177 | ||
Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele | Q39467907 | ||
Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity. | Q39499831 | ||
Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS. | Q39521587 | ||
Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol | Q39574110 | ||
Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface | Q31010231 | ||
Sphingomyelin functions as a novel receptor for Helicobacter pylori VacA. | Q33337132 | ||
Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer | Q33397617 | ||
Helicobacter pylori counteracts the apoptotic action of its VacA toxin by injecting the CagA protein into gastric epithelial cells | Q33508239 | ||
Epidemiological link between gastric disease and polymorphisms in VacA and CagA. | Q33627481 | ||
Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world. | Q33704877 | ||
Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains | Q33756022 | ||
Experimental infection of Mongolian gerbils with wild-type and mutant Helicobacter pylori strains. | Q33765863 | ||
Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells | Q33892318 | ||
Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion | Q34004880 | ||
Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection | Q34005878 | ||
Reconstitution of Helicobacter pylori VacA toxin from purified components | Q34020343 | ||
Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study | Q34058754 | ||
Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. | Q34060888 | ||
A role for the vacuolating cytotoxin, VacA, in colonization and Helicobacter pylori-induced metaplasia in the stomach. | Q34061670 | ||
Plasma membrane cholesterol modulates cellular vacuolation induced by the Helicobacter pylori vacuolating cytotoxin | Q34128764 | ||
How the loop and middle regions influence the properties of Helicobacter pylori VacA channels | Q34176969 | ||
Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA. | Q34307421 | ||
Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA | Q34309390 | ||
Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion | Q34337364 | ||
Effects of Helicobacter pylori vacuolating cytotoxin on primary cultures of human gastric epithelial cells | Q34410620 | ||
A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens | Q34433312 | ||
Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA | Q34622430 | ||
Two different families of hopQ alleles in Helicobacter pylori | Q34989456 | ||
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms | Q35024882 | ||
Role of connexin 43 in Helicobacter pylori VacA-induced cell death. | Q35031766 | ||
Helicobacter pylori homB, but not cagA, is associated with gastric cancer in Iran | Q35192226 | ||
Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death | Q35229084 | ||
Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells. | Q35329090 | ||
Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease | Q35446326 | ||
Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells | Q35524677 | ||
Helicobacter pylori cytotoxin induces vacuolation of primary human mucosal epithelial cells | Q35530398 | ||
Helicobacter pylori genotypes may determine gastric histopathology | Q35746254 | ||
Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions. | Q51105191 | ||
The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes. | Q51800308 | ||
Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin. | Q54488246 | ||
Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. | Q54533319 | ||
The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer. | Q54585937 | ||
Purification and characterization of the vacuolating toxin from Helicobacter pylori | Q55040857 | ||
Interactions between p-33 and p-55 Domains of theHelicobacter pyloriVacuolating Cytotoxin (VacA) | Q57372198 | ||
Vacuolating cytotoxin purified fromHelicobacter pyloricauses mitochondrial damage in human gastric cells | Q57838362 | ||
Helicobacter pyloritoxin VacA induces vacuole formation by acting in the cell cytosol | Q57988344 | ||
Geographic distribution of vacA allelic types of Helicobacter pylori | Q59182779 | ||
Helicobacter pylori cagA and vacA Genotypes as Predictors of Progression of Gastric Preneoplastic Lesions: A Long-Term Follow-Up in a High-Risk Area in Spain | Q60651512 | ||
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori | Q71933876 | ||
Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach | Q72220074 | ||
Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin | Q73075605 | ||
A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation | Q73297523 | ||
Effect of helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation | Q73735525 | ||
The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany | Q74008989 | ||
Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells | Q74130079 | ||
Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia | Q74295902 | ||
Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma | Q74444375 | ||
Identification of the minimal intracellular vacuolating domain of the Helicobacter pylori vacuolating toxin | Q74638047 | ||
Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines | Q77743650 | ||
A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer | Q81248691 | ||
Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets | Q81386332 | ||
Helicobacter pylori outer membrane proteins and gastroduodenal disease | Q35760550 | ||
Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori | Q35778449 | ||
Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments. | Q35808932 | ||
Helicobacter pylori VacA, a paradigm for toxin multifunctionality | Q36066993 | ||
The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay | Q36211197 | ||
Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA | Q36225705 | ||
Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly | Q36267567 | ||
Growth phase-dependent composition of the Helicobacter pylori exoproteome. | Q36269115 | ||
Helicobacter pylori adaptation in vivo in response to a high-salt diet | Q36281345 | ||
The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity. | Q36289594 | ||
Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex. | Q36496585 | ||
Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin | Q36556507 | ||
Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance | Q36637575 | ||
Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin | Q36730681 | ||
Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells | Q36897639 | ||
High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis | Q36911517 | ||
Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway | Q37164224 | ||
Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin | Q37221150 | ||
homB status of Helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer | Q37374941 | ||
Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination. | Q37387894 | ||
Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases | Q37410450 | ||
Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration | Q37424965 | ||
Gap junctions and cancer: communicating for 50 years | Q37613777 | ||
Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus | Q37847237 | ||
Architecture of the Helicobacter pylori Cag-type IV secretion system | Q37847238 | ||
Intoxication strategy of Helicobacter pylori VacA toxin | Q37988019 | ||
Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA). | Q38037546 | ||
Gastric cancer: epidemiology and risk factors. | Q38103683 | ||
Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis | Q38195961 | ||
Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma | Q38273493 | ||
Two distinctive cell binding patterns by vacuolating toxin fused with glutathione S-transferase: one high-affinity m1-specific binding and the other lower-affinity binding for variant m forms | Q38296591 | ||
Multiple chromosomal loci for the babA gene in Helicobacter pylori | Q38314155 | ||
Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation | Q38351208 | ||
A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain. | Q38759666 | ||
P275 | copyright license | Creative Commons Attribution | Q6905323 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 10 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Helicobacter pylori | Q180556 |
stomach neoplasm | Q4335552 | ||
bacterial protein | Q64923821 | ||
P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
P577 | publication date | 2017-10-12 | |
P1433 | published in | Toxins | Q15724569 |
P1476 | title | Helicobacter pylori Vacuolating Toxin and Gastric Cancer | |
P478 | volume | 9 |
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