Design and synthesis of pathway genes for polyketide biosynthesis.

scientific article published in January 2009

Design and synthesis of pathway genes for polyketide biosynthesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0076-6879(09)04614-X
P698PubMed publication ID19362646

P50authorHugo G. MenzellaQ54478450
P2093author name stringHugo Gramajo
Salvador Peirú
P2860cites workGeMS: an advanced software package for designing synthetic genesQ24806471
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.Q30650504
Combinatorial biosynthesis for drug developmentQ33286975
API-mass spectrometry of polyketides. I. A study on the fragmentation of triketide lactonesQ33431655
Metabolically engineered Escherichia coli for efficient production of glycosylated natural products.Q33801571
Polyketide and nonribosomal peptide antibiotics: modularity and versatilityQ33976771
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Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.Q34360747
In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.Q34499313
Genetic approaches to polyketide antibiotics. 1.Q36034625
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Engineered biosynthesis of a complete macrolactone in a heterologous hostQ36734757
Production of the potent antibacterial polyketide erythromycin C in Escherichia coliQ40425373
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthasesQ40647813
Total synthesis of multi-kilobase DNA sequences from oligonucleotidesQ43811300
An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesisQ44114476
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B productionQ44536620
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.Q44552141
Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domainsQ46424964
Heterologous production of epothilone C and D in Escherichia coli.Q46609321
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.Q46832912
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analoguesQ48564883
The Lego-ization of polyketide biosynthesis.Q51358168
Characterization of the heterodimeric MegBIIa:MegBIIb aldo-keto reductase involved in the biosynthesis of L-mycarose from Micromonospora megalomicea.Q54439655
Rational design and assembly of synthetic trimodular polyketide synthases.Q54446263
Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster.Q54478342
A hybrid modular polyketide synthase obtained by domain swappingQ71824462
Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavageQ72287446
Engineered intermodular and intramodular polyketide synthase fusionsQ73790571
Dissecting and exploiting intermodular communication in polyketide synthasesQ77330305
P407language of work or nameEnglishQ1860
P304page(s)319-337
P577publication date2009-01-01
P1433published inMethods in EnzymologyQ2076903
P1476titleDesign and synthesis of pathway genes for polyketide biosynthesis
P478volume459

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cites work (P2860)
Q34420446Complex function by design using spatially pre-structured synthetic microbial communities: degradation of pentachlorophenol in the presence of Hg(ii).
Q38189354Expression of codon optimized genes in microbial systems: current industrial applications and perspectives.

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