Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome

scientific article

Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.PHAREP.2016.12.001
P932PMC publication ID5367634
P698PubMed publication ID28187396

P50authorStephen M. HusbandsQ42352975
Jakub FichnaQ22115026
P2093author name stringMarta Zielińska
Agata Jarmuż
Gerta Cami-Kobeci
Andrzej Wasilewski
P2860cites workAntinociceptive, antidiarrheal, and neuropharmacological activities of Barringtonia acutangulaQ43347150
Antisecretory effect of loperamide in colon epithelial cells by inhibition of basolateral K+ conductanceQ43667459
Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptorsQ44343638
Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activityQ44343837
TH-030418: a potent long-acting opioid analgesic with low dependence liabilityQ44350826
Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivityQ44351610
Mixed MOP/DOP agonist biphalin elicits anti-transit effect in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptomsQ57105487
Orally administered novel cyclic pentapeptide P-317 alleviates symptoms of diarrhoea-predominant irritable bowel syndromeQ57108024
Gastrointestinal actions of buprenorphine: are different receptors involved?Q71943056
Regulation of intestinal Cl- and HCO3-secretion by uroguanylinQ74518335
Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: new potential treatment of abdominal pain associated with inflammatory bowel diseasesQ87645850
Dissociation of castor oil-induced diarrhoea and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl esterQ28368875
Functional bowel disordersQ29620328
Novel analgesics and molecular rearrangements in the morphine-thebaine group. III. Alcohols of the 6,14-endo-ethenotetrahydrooripavine series and derived analogs of N-allylnormorphine and -norcodeineQ34054548
The orvinols and related opioids--high affinity ligands with diverse efficacy profilesQ34307193
Opioid receptors in the gastrointestinal tractQ35185222
The regulation of veratridine-stimulated electrogenic ion transport in mouse colon by neuropeptide Y (NPY), Y1 and Y2 receptorsQ35545073
Effects of mu and kappa opioid receptor agonists and antagonists on contraction of isolated colon strips of rats with cathartic colonQ36067542
Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonistQ36382976
Effect of thienorphine on intestinal transit and isolated guinea-pig ileum contractionQ36699289
Orvinols with mixed kappa/mu opioid receptor agonist activityQ36822435
Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectivesQ37491434
Antidiarrheal activity of ethanolic extract of Manihot esculenta Crantz leaves in Wistar ratsQ39605053
Insights into opioid action in the intestinal tractQ41293298
P433issue2
P921main subjectdiarrheaQ40878
P304page(s)350-357
P577publication date2016-12-05
P1433published inPharmacological ReportsQ15766499
P1476titleMethyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome
P478volume69

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cites work (P2860)
Q89459062Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract
Q49677641Existing and emerging therapies for managing constipation and diarrhea

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