Statin effects on cholesterol micro-domains in brain plasma membranes

scientific article published in March 2003

Statin effects on cholesterol micro-domains in brain plasma membranes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-2952(02)01654-4
P698PubMed publication ID12628479

P2093author name stringGunter P Eckert
Walter E Mueller
Christopher Kirsch
P2860cites workPolarization of the fluorescence of macromolecules. I. Theory and experimental methodQ24531310
Lipid rafts and signal transductionQ28131735
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based studyQ28366850
A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes.Q30329988
The role of cholesterol in the biosynthesis of beta-amyloidQ30779994
Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cellsQ31583322
Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundanceQ31796937
Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's diseaseQ33609376
Amyloid and lipids in the pathology of Alzheimer disease.Q33706311
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.Q33921362
Non-lipid-related effects of statinsQ33924588
Cholesterol depletion induces large scale domain segregation in living cell membranesQ33949091
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid raftsQ34088442
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's diseaseQ34094305
Cholesterol attenuates the membrane perturbing properties of beta-amyloid peptidesQ44199468
Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domainsQ44288428
Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).Q48164740
In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitorsQ48181561
Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.Q48202659
beta-Amyloid protein amplifies calcium signalling in central neurons from the adult mouseQ48232512
Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterolQ48482911
Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins.Q48610121
Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's diseaseQ48761995
Plasma membrane lipid composition modulates action of anesthetics.Q51803260
Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice?Q52531799
Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.Q52539745
Transbilayer effects of ethanol on fluidity of brain membrane leaflets.Q52547157
Temperature, pressure and cholesterol effects on bilayer fluidity; a comparison of pyrene excimer/monomer ratios with the steady-state fluorescence polarization of diphenylhexatriene in liposomes and microsomesQ57251360
Transmembrane distribution of sterol in the human erythrocyteQ67919225
Low-density lipoprotein receptor on endothelium of brain capillariesQ69653609
Determination of lipid phosphorus in the nanomolar rangeQ71601310
Cholesterol domains in biological membranesQ72279452
Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophagesQ72325369
Modulation of ATPase activities of human erythrocyte membranes by free fatty acids or phospholipase A2Q72534985
Comparative toxicity of high doses of vastatins currently used by clinicians, in CD-1 male mice fed with a hypercholesterolemic dietQ78181101
How cells handle cholesterol.Q34094514
Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasisQ34117380
Cholesterol metabolism in the brainQ34193085
Use of statins in CNS disordersQ34300585
Essential fatty acids as possible mediators of the actions of statinsQ34327189
Membrane-disordering effects of beta-amyloid peptidesQ34332530
Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol traffickingQ34420952
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitorsQ34432988
Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitorsQ34460973
Statins in the 21st century: end of the simple story?Q34481748
A comparison of clinical outcome studies among cholesterol-lowering agentsQ34495746
Statins and the risk of dementiaQ34511970
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivoQ34514599
Cholesterol, A beta and Alzheimer's diseaseQ34553838
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neuronsQ34663462
Apolipoprotein-E allele-specific regulation of nitric oxide production.Q34699682
Location of diphenylhexatriene (DPH) and its derivatives within membranes: comparison of different fluorescence quenching analyses of membrane depthQ34747493
Cholesterol and Alzheimer's diseaseQ34797411
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.Q35897595
A fluid connection: cholesterol and AbetaQ35906228
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthaseQ36225423
Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasisQ36650009
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.Q37176000
Alzheimer's disease: a central role for amyloidQ40701623
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptideQ40777105
Use of fluorescent probes to monitor molecular order and motions within liposome bilayersQ40781479
Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloidQ40807391
Non-lipid-related effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitorsQ40922775
Recent advances in membrane cholesterol domain dynamics and intracellular cholesterol traffickingQ41226568
Cholesterol modulates alpha-secretase cleavage of amyloid precursor proteinQ41226800
Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitorsQ41445253
Carrier-mediated uptake of pravastatin by rat hepatocytes in primary cultureQ41639392
Charged anaesthetics alter LM-fibroblast plasma-membrane enzymes by selective fluidization of inner or outer membrane leafletsQ42854763
Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient miceQ43575926
Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects.Q43578320
Alzheimer's disease. Bad for the heart, bad for the mind?Q43614473
Effects of aging and beta-amyloid on the properties of brain synaptic and mitochondrial membranesQ43804305
Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brainQ43885523
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomainsQ43889089
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.Q43906981
Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in miceQ43945469
Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic miceQ43945499
Potential neurological value of statins increasesQ44013439
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)843-856
P577publication date2003-03-01
P1433published inBiochemical PharmacologyQ864229
P1476titleStatin effects on cholesterol micro-domains in brain plasma membranes
P478volume65