Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes

scientific article published on 9 May 2013

Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/TRA.12074
P698PubMed publication ID23590328
P5875ResearchGate publication ID236212682

P50authorUlf MattiQ42779196
Elmar KrauseQ38322974
Jens RettigQ38322992
Markus HothQ38329443
Martina SesterQ40314126
P2093author name stringClaudia Schirra
Martin Jung
Misty R Marshall
Ute Becherer
Peter Lipp
Varsha Pattu
Jan Dirks
Monika Maier-Peuschel
Mahantappa Halimani
Monika Dudenhöffer-Pfeifer
P2860cites workCentriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systemsQ21245308
Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4Q24293621
Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytesQ24298095
Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cellsQ40430145
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter releaseQ41017986
Two distinct secretory vesicle-priming steps in adrenal chromaffin cellsQ41966374
Vesicle pools: lessons from adrenal chromaffin cellsQ42699533
Rab27a is required for regulated secretion in cytotoxic T lymphocytesQ42947316
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25.Q44758007
Methods for analysis of rab27a/Munc13-4 in secretory lysosome release in hematopoietic cellsQ46644057
Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopyQ46699234
Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).Q48219972
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.Q48673213
Identification of the minimal protein domain required for priming activity of Munc13-1.Q50748500
Centrosome polarization delivers secretory granules to the immunological synapse.Q53587934
Calmodulin and Munc13 Form a Ca2+ Sensor/Effector Complex that Controls Short-Term Synaptic PlasticityQ58191207
The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.Q59211381
Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen miceQ24671578
Docking of LDCVs is modulated by lower intracellular [Ca2+] than primingQ27303636
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesiclesQ27863297
Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteinsQ28289561
Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxinQ28301542
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle primingQ28504670
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosisQ28506181
Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoformQ28576630
The synaptic vesicle cycle: a cascade of protein-protein interactionsQ29620168
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndromeQ29620423
Regulation of transmitter release by Unc-13 and its homologuesQ33941560
Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasisQ34074906
Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophilsQ34568573
Genetic defects affecting lymphocyte cytotoxicityQ36791314
Multiple roles of calcium ions in the regulation of neurotransmitter releaseQ37279408
The Ca(2+)-dependent activator protein for secretion CAPS: do I dock or do I prime?Q37374551
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granulesQ37773158
Understanding the structure and function of the immunological synapseQ37789101
Munc13 homology domain-1 in CAPS/UNC31 mediates SNARE binding required for priming vesicle exocytosisQ39497953
The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membraneQ39520527
Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granulesQ39588014
The exocytosis of lytic granules is impaired in Vti1b- or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activationQ39693909
Phosphorylation of SNAP-25 at Ser187 mediates enhancement of exocytosis by a phorbol ester in INS-1 cellsQ40028850
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
P304page(s)798-809
P577publication date2013-05-09
P1433published inTrafficQ1572846
P1476titleDifferent Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes
P478volume14

Reverse relations

cites work (P2860)
Q27322999Behavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes
Q58553974Coupling the Structural and Functional Assembly of Synaptic Release Sites
Q47232616Cytotoxic granule endocytosis depends on the Flower protein
Q38759000Exocytosis in non-neuronal cells
Q38172133In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology
Q38168511Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes
Q89837486Molecular regulation of the plasma membrane-proximal cellular steps involved in NK cell cytolytic function
Q47398975Munc13 proteins control regulated exocytosis in mast cells
Q55690034Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation.
Q38944118Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
Q42155668Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion
Q64990182Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.
Q38192676Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?
Q44625161Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes
Q38689283The dendritic cell side of the immunological synapse

Search more.