The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation

scientific article published in March 2003

The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BMT.1703896
P698PubMed publication ID12665836
P5875ResearchGate publication ID10830147

P50authorPer LjungmanQ52717443
P2093author name stringHassan M
Ringdén O
Nilsson C
Aschan J
Hentschke P
P2860cites workA phase I/II study of multiple-dose intravenous busulfan as myeloablation prior to stem cell transplantationQ31536804
Why metronidazole is active against both bacteria and parasitesQ33676773
Clinically significant pharmacokinetic drug interactions with carbamazepine. An updateQ34403438
Metronidazole and antipyrine as probes for the study of foreign compound metabolismQ37918077
Venoocclusive disease of the liver following bone marrow transplantationQ39688572
Cytochrome P450 isozymes and antiepileptic drug interactionsQ41112031
An evaluation of engraftment, toxicity and busulfan concentration in children receiving bone marrow transplantation for leukemia or genetic diseaseQ41734536
Pharmacokinetics of liposomal busulphan in man.Q43583155
The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirementQ43659549
Metabolism of 14C-busulfan in isolated perfused rat liverQ43692742
Intravenous busulphan for conditioning before autologous or allogeneic human blood stem cell transplantationQ43742785
Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studiesQ43819615
Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemiaQ44237334
Influence of prophylactic anticonvulsant therapy on high-dose busulphan kinetics.Q51676244
[Interstitial pneumopathies caused by busulfan. Histologic, developmental and bronchoalveolar lavage analysis of 3 cases].Q52250479
Comparison of the sensitivity of human and rat hepatocytes to the genotoxic effects of metronidazole.Q54324449
The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicityQ58789353
Metabolism of metronidazole and antipyrine in isolated rat hepatocytesQ61794888
Pharmacokinetic and metabolic studies of high-dose busulphan in adultsQ69665196
Busulfan disposition and hepatic veno-occlusive disease in children undergoing bone marrow transplantationQ70806164
Gas chromatographic determination of busulfan in plasma with electron-capture detectionQ71104880
Acute safety and pharmacokinetics of intravenous busulfan when used with oral busulfan and cyclophosphamide as pretransplantation conditioning therapy: a phase I studyQ73171815
Binding of 3H-metronidazole in olfactory, respiratory and alimentary epithelia in ratsQ73701022
An improved limited sampling method for individualised busulphan dosing in bone marrow transplantation in childrenQ73810014
Ketobemidone may alter busulfan pharmacokinetics during high-dose therapyQ74171110
Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrowQ77780489
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmetronidazoleQ169569
pharmacokineticsQ323936
P304page(s)429-435
P577publication date2003-03-01
P1433published inBone Marrow TransplantationQ4941523
P1476titleThe effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation
P478volume31

Reverse relations

cites work (P2860)
Q36659821A systematic review on drug interactions in oncology
Q46091045Body weight-dependent pharmacokinetics of busulfan in paediatric haematopoietic stem cell transplantation patients: towards individualized dosing
Q52552920Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review.
Q37334707Clinically significant drug-drug interactions between oral anticancer agents and nonanticancer agents: profiling and comparison of two drug compendia.
Q42212406Clostridium difficile Infection (CDI) in Solid Organ and Hematopoietic Stem Cell Transplant Recipients.
Q51016254Development of an assay for cellular efflux of pharmaceutically active agents and its relevance to understanding drug interactions.
Q34409335Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103).
Q43122468Effect of metronidazole on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy male volunteers
Q37358921Effect of weight and maturation on busulfan clearance in infants and small children undergoing hematopoietic cell transplantation
Q47116870Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway.
Q46910175Individual dose adjustment of oral busulfan using a test dose in hematopoietic stem cell transplantation
Q38099040Interactions between oral antineoplastic agents and concomitant medication: a systematic review
Q84405861Order of application and liver toxicity in patients given BU and CY containing conditioning regimens for allogeneic hematopoietic SCT
Q35126138Population pharmacokinetics of busulfan in pediatric and young adult patients undergoing hematopoietic cell transplant: a model-based dosing algorithm for personalized therapy and implementation into routine clinical use.
Q38068541Role of pharmacogenetics in busulfan/cyclophosphamide conditioning therapy prior to hematopoietic stem cell transplantation
Q36792760Variability in the pharmacokinetics of intravenous busulphan given as a single daily dose to paediatric blood or marrow transplant recipients
Q100762129Vitamin D levels and busulphan kinetics in patients undergoing hematopoietic stem cell transplantation, a multicenter study

Search more.