Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease

scientific article published on March 1, 2003

Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1044-7431(02)00013-1
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S1044743102000131?httpAccept=text/plain
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P698PubMed publication ID12691731

P50authorDe-Maw ChuangQ122376016
P2093author name stringVinod Charles
P. H. Reddy
Vladimir V. Senatorov
Dan A. Tagle
P2860cites workA novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's diseaseQ28114818
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutationQ28246858
Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenylQ28263664
Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenaseQ28293728
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's diseaseQ28589793
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceQ29615357
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brainQ29617982
New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase.Q30322264
Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblastsQ32034809
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's diseaseQ33292417
Recent advances on the pathogenesis of Huntington's diseaseQ33604650
The selective vulnerability of striatopallidal neuronsQ33939097
Loss of normal huntingtin function: new developments in Huntington's disease researchQ34142361
Reactive oxygen species are downstream mediators of p53-dependent apoptosisQ34403292
Mouse models of Huntington's diseaseQ34502714
Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's diseaseQ35176635
Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's diseaseQ35212462
Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell deathQ36605673
Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinonucleoside-induced apoptosis in cultured cerebellar neuronsQ37368739
Stress and the aging hippocampusQ38461795
Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aortaQ42521955
Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.Q45288480
Cortical and striatal neurone number in Huntington's diseaseQ45288776
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.Q45291767
A role for GAPDH in apoptosis and neurodegenerationQ45291886
Neuronal loss in layers V and VI of cerebral cortex in Huntington's diseaseQ45293583
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivoQ45294913
Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatumQ45296389
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.Q45296558
Glyceraldehyde 3-phosphate dehydrogenase abnormality in metabolically stressed Huntington disease fibroblasts.Q45296630
Brain glyceraldehyde-3-phosphate dehydrogenase activity in human trinucleotide repeat disordersQ45296636
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtinQ45297223
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.Q45298582
Normal and mutant huntingtin: partners in crimeQ45301570
Regional and progressive thinning of the cortical ribbon in Huntington's diseaseQ45305508
DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological ConditionsQ45307545
Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomeraseQ47692379
Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase isoforms during neuronal apoptosisQ48275909
Subcellular distribution of glyceraldehyde-3-phosphate dehydrogenase in cerebellar granule cells undergoing cytosine arabinoside-induced apoptosisQ48544021
Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in cultureQ49087408
Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in miceQ56772848
Endothelial cell hypoxic stress proteinsQ58486025
Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53Q73107353
Ethidium bromide staining reveals rapid cell dispersion in the rat dentate gyrus following ouabain-induced injuryQ73320594
Huntington's diseaseQ74093232
Nuclear translocation of GAPDH-GFP fusion protein during apoptosisQ77733233
mRNA expression of glycolytic enzymes and glucose transporter proteins in ischemic myocardium with and without reperfusionQ77927019
Estimation of nuclear population from microtome sectionsQ82126847
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
Huntington's diseaseQ190564
overexpressionQ61643320
P304page(s)285-297
P577publication date2003-03-01
P1433published inMolecular and Cellular NeuroscienceQ6895985
P1476titleOverexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington's disease
Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease
P478volume22